公开(公告)号：EP2655427A1

公开(公告)日：2013-10-30

申请号：EP11804499.9

申请日：2011-12-20

申请人： Dentsply DeTrey GmbH

发明人： KLEE, Joachim, E. ,  RITTER, Helmut ,  MAIER, Maximilian ,  GANSEL, Julia ,  FACHER, Andreas ,  ELSNER, Oliver ,  POHLE, Sven

IPC分类号： C08F8/00 ,  C08F8/46 ,  A61K6/083

CPC分类号： A61K6/0835 ,  C08F8/00 ,  C08F8/12 ,  C08F8/46 ,  C08F220/06 ,  C08F220/18 ,  C08F220/12 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26

摘要： A process for producing a water-soluble, hydrolysis-stable, polymerizable polymer, comprising a) a step of copolymerizing a mixture comprising (i) a first copolymerizable monomer comprising at least one optionally protected carboxylic acid group and a first polymerizable organic moiety, and (ii) a second copolymerizable monomer comprising one or more optionally protected primary and/or secondary amino groups and a second polymerizable organic moiety, for obtaining an amino group containing copolymer; b) a step of coupling to the amino group containing copolymer a compound having a polymerizable moiety and a functional group reactive with an amino group of repeating units derived from the second copolymerizable monomer in the amino group containing copolymer obtained in the first step wherein the optionally protected amino group is deprotected, so that polymerizable pendant groups are linked to the backbone by hydrolysis-stable linking groups, and, optionally, a step of deprotecting the protected carboxylic acid group after step (a) or step (b), for obtaining a polymerizable polymer.

公开(公告)号：EP1651165B1

公开(公告)日：2009-06-03

申请号：EP04763677.4

申请日：2004-07-30

申请人： DENTSPLY DETREY GmbH

发明人： KLEE, Joachim, E.

IPC分类号： A61K6/00 ,  A61K6/087

CPC分类号： A61K6/0038 ,  C08L79/02 ,  C08L33/00

摘要： A dental root canal sealing composition curable in the absence of a polymerisation initiator and having a viscosity at 23°C of less than 100 Pas, which comprises (i) an amino terminated prepolymer obtainable by reacting (a) one mole of a compound of the following formula (I) wherein X represents a nitrogen or an oxygen atom; Z represents an n-valent saturated aliphatic or cycloaliphatic C2-16 hydrocarbon group which may contain 1 to 6 oxygen atoms, and which may be substituted by one or more C1-4 alkyl groups; and n represents an integer of from 2 to 6; and (b) at least n moles of one or more compounds either of the following formula (II) wherein R represents a C1-6 alkyl or a C3-,4 cycloalkyl group, which may be substituted by one or more (up to six) members of the group selected from a C1-4 alkyl group, C1-4 alkoxy group, a phenyl group, and a hydroxy group, or of formula (11) in combination with one or more di- or polyamine compound; (ii) a di-or polyfunctional acrylate compound or a di- or polyfunctional maleimide compound which is capable of undergoing polyaddition with the aminotherminated prepolymer (i); (iii) 40 to 85 wt.-% of a filler for providing a minimum radioopacity of at least 3mm/mm AI; said composition being in the form of a two-component composition wherein a first component contains the amino terminated prepolymer (i) and optionally filler (iii) and a second component (ii) capable of undergoing polyaddition with the aminoterminated prepolymer (i) and optionally filler (iii).

公开(公告)号：EP1843714A1

公开(公告)日：2007-10-17

申请号：EP06706627.4

申请日：2006-02-03

申请人： Dentsply DeTrey GmbH

发明人： GRÜTZNER, Andreas, E. ,  KLEE, Joachim, E.

IPC分类号： A61C5/04 ,  A61K6/00

CPC分类号： A61C5/50

摘要： Kit-of-parts containing (i) a dental device for use in the obturation of a root canal which comprises a tapered obturating point portion integrally connected at the distal end of a functional portion, whereby the functional portion comprises (a) a neck portion adjacent to the obturating point portion, and (b) a handle portion, and (ii) a dental sealant composition, wherein the dental device is made of a material obtainable by curing a composition containing one or more curable components contained in the dental sealant.

摘要翻译： 零件包含（i）用于根管密封的牙科装置，其包括在功能部分的远端处整体连接的锥形填塞点部分，由此所述功能部分包括（a）颈部 和（b）手柄部分，和（ii）牙科密封剂组合物，其中所述牙科装置由可通过固化包含在所述牙科密封剂中包含的一种或多种可固化组分的组合物获得的材料制成。

公开(公告)号：EP1651165A1

公开(公告)日：2006-05-03

申请号：EP04763677.4

申请日：2004-07-30

申请人： DENTSPLY DETREY GmbH

发明人： KLEE, Joachim, E.

IPC分类号： A61K6/00 ,  A61K6/087

CPC分类号： A61K6/0038 ,  C08L79/02 ,  C08L33/00

摘要： A dental root canal sealing composition curable in the absence of a polymerisation initiator and having a viscosity at 23°C of less than 100 Pas, which comprises (i) an amino terminated prepolymer obtainable by reacting (a) one mole of a compound of the following formula (I) wherein X represents a nitrogen or an oxygen atom; Z represents an n-valent saturated aliphatic or cycloaliphatic C2-16 hydrocarbon group which may contain 1 to 6 oxygen atoms, and which may be substituted by one or more C1-4 alkyl groups; and n represents an integer of from 2 to 6; and (b) at least n moles of one or more compounds either of the following formula (II) wherein R represents a C1-6 alkyl or a C3-,4 cycloalkyl group, which may be substituted by one or more (up to six) members of the group selected from a C1-4 alkyl group, C1-4 alkoxy group, a phenyl group, and a hydroxy group, or of formula (11) in combination with one or more di- or polyamine compound; (ii) a di-or polyfunctional acrylate compound or a di- or polyfunctional maleimide compound which is capable of undergoing polyaddition with the aminotherminated prepolymer (i); (iii) 40 to 85 wt.-% of a filler for providing a minimum radioopacity of at least 3mm/mm AI; said composition being in the form of a two-component composition wherein a first component contains the amino terminated prepolymer (i) and optionally filler (iii) and a second component (ii) capable of undergoing polyaddition with the aminoterminated prepolymer (i) and optionally filler (iii).

公开(公告)号：EP1750648B1

公开(公告)日：2009-06-17

申请号：EP05729695.6

申请日：2005-04-01

申请人： DENTSPLY DETREY GmbH

发明人： KLEE, Joachim, E. ,  BRUGGER, Stefan ,  WEBER, Christoph ,  MÜLLER, Axel, H., E. ,  MORI, Hideharu

IPC分类号： A61K6/08

CPC分类号： A61K6/0008 ,  A61K6/0835 ,  A61K6/093 ,  C08L83/10 ,  C08L33/00 ,  C08L25/04

摘要： A dental cement composition comprising (i) a particulate reactive inorganic filler capable of leaching metal ions in the presence of an acid, and (ii) composite particles with grafted polyacidic polymer chains, which are obtainable by a process comprising the following steps: (a) polymerizing one or more free radically polymerizable monomers containing optionally protected acidic groups in the presence of (a1) an initiatior system comprising initiator particles displaying a moiety comprising a radically transferable atom or group as a polymerization initiation site; and (a2) a catalyst facilitating controlled/living polymerisation, and (a3) optionally further polymerizable monomers, for forming a composite particle with grafted optionally protected polyacidic polymer chains; and (b) optionally deprotecting protected acidic groups, for forming composite particles with grafted polyacidic polymer chains.

公开(公告)号：EP1750648A1

公开(公告)日：2007-02-14

申请号：EP05729695.6

申请日：2005-04-01

申请人： DENTSPLY DETREY GmbH

发明人： KLEE, Joachim, E. ,  BRUGGER, Stefan ,  WEBER, Christoph ,  MÜLLER, Axel, H., E. ,  MORI, Hideharu

IPC分类号： A61K6/08

CPC分类号： A61K6/0008 ,  A61K6/0835 ,  A61K6/093 ,  C08L83/10 ,  C08L33/00 ,  C08L25/04

摘要： A dental cement composition comprising (i) a particulate reactive inorganic filler capable of leaching metal ions in the presence of an acid, and (ii) composite particles with grafted polyacidic polymer chains, which are obtainable by a process comprising the following steps: (a) polymerizing one or more free radically polymerizable monomers containing optionally protected acidic groups in the presence of (a1) an initiatior system comprising initiator particles displaying a moiety comprising a radically transferable atom or group as a polymerization initiation site; and (a2) a catalyst facilitating controlled/living polymerisation, and (a3) optionally further polymerizable monomers, for forming a composite particle with grafted optionally protected polyacidic polymer chains; and (b) optionally deprotecting protected acidic groups, for forming composite particles with grafted polyacidic polymer chains.

公开(公告)号：EP1648375A1

公开(公告)日：2006-04-26

申请号：EP04741340.6

申请日：2004-07-30

申请人： DENTSPLY DETREY GmbH

发明人： KLEE, Joachim, E.

IPC分类号： A61K6/00 ,  A61K6/087

CPC分类号： A61K6/0038 ,  C08L33/00 ,  C08L79/02

摘要： A dental root canal sealing composition curable in the absence of a polymerisation initiator, which comprises: (i) an amino terminated prepolymer having a viscosity at 230C of less than 100 Pas, which is obtainable by reacting (a) one mole of a compound of the formula (I) wherein X represents a nitrogen or an oxygen atom; Z represents an n-valent saturated aliphatic C2-16 hydrocarbon group or a divalent saturated cycloaliphatic C3-6 hydrocarbon group, which groups may contain 1 to 6 oxygen atoms, and which may be substituted by 1 to 6 C1-4 alkyl groups; and n represents an integer of from 2 to 6; (b) at least n moles of one or more compounds either of the following formula (II) wherein A represents a divalent saturated aliphatic C2-16 hydrocarbon group or a divalent saturated cycloaliphatic C3-6 hydrocarbon group, which groups may contain 1 to 6 oxygen atoms, and which may be substituted by 1 to 6 C1-4 alkyl groups; Ra and Rb are the same or different and represent a hydrogen atom, a C1-6 alkyl or a C3-14 cycloalkyl group, which may be substituted by one or more members of the group selected from a C1-4 alkyl group, C1-4 alkoxy group, a phenyl group, and a hydroxy group; or of formula (II) in combination with one or more compounds of a formula RNH2, wherein R represents C1-6 alkyl or a C3-14 cycloalkyl group, which may be substituted by one or more members of the group selected from a C1-4 alkyl group, C1-4 alkoxy group, a phenyl group, and a hydroxy group, and/or in combination with a further di- or polyamine compound; (ii) a di- or polyfunctional acrylate compound or a di- or polyfunctional maleimide compound which is capable of undergoing polyaddition with the aminoterminated prepolymer (i); (iii) 40 to 85 wt.-% of a filler for providing a minimum radioopacity of at least 3mm/mm Al; said compositon being in the form of a two-component composition wherein a first component contains the amino terminated prepolymer (i) and optionally filler (iii) and a second component contains the compound (ii) capable of undergoing polyaddition with the aminoterminated prepolymer (i) and optionally filler (iii).

公开(公告)号：EP3675800A1

公开(公告)日：2020-07-08

申请号：EP18759127.6

申请日：2018-08-30

申请人： Dentsply DeTrey GmbH

发明人： MAIER, Maximilian ,  KLEE, Joachim, E. ,  SCHEUFLER, Christian ,  RENN, Caroline ,  SZILLAT, Florian

IPC分类号： A61K6/083 ,  A61K6/00

公开(公告)号：EP2655427B1

公开(公告)日：2019-03-27

申请号：EP11804499.9

申请日：2011-12-20

申请人： Dentsply DeTrey GmbH

发明人： KLEE, Joachim, E. ,  RITTER, Helmut ,  MAIER, Maximilian ,  GANSEL, Julia ,  FACHER, Andreas ,  ELSNER, Oliver ,  POHLE, Sven

IPC分类号： C08F8/00 ,  C08F8/46 ,  A61K6/083 ,  C08F8/12

公开(公告)号：EP2629740A1

公开(公告)日：2013-08-28

申请号：EP11771039.2

申请日：2011-10-18

申请人： Dentsply DeTrey GmbH

发明人： STELZIG, Simon ,  KLEE, Joachim, E. ,  FACHER, Andreas ,  WEBER, Christoph

IPC分类号： A61K6/02 ,  A61K6/083 ,  C07C233/31

CPC分类号： A61K6/083 ,  A61K6/0023 ,  A61K6/0835 ,  C07C233/20 ,  C08L33/00

摘要： Dental composition comprising a water-soluble polymerizable compound of the following formula (1): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ AX n €ƒ€ƒ€ƒ€ƒ€ƒ(1) wherein A is a straight chain or branched linker group containing least n nitrogen atoms, whereby the linker group has polyoxyalkylene and/or polyalkylene imine repeating units and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, wherein each X may be the same or different and are represented by the following formula (2): wherein R 1 and R 2 are independent from each other and represent a hydrogen atom, a C 1-6 alkyl group or a group -(CH 2 ) m -COOM, wherein M represents a hydrogen atom or a metal atom, m is an integer of from 0 to 6, L is a bond or a C 1-6 alkylene group; and n is an integer of at least 1; (ii) an initiator system; optionally a polyacidic polymer; optionally water and/or a water soluble solvent; and optionally a particulate filler.

摘要翻译： 包含下式（1）的水溶性可聚合化合物的牙科组合物：（1）其中A 是含有至少n个氮原子的直链或支链连接基团，其中连接基团具有聚氧化烯和/或聚亚烷基亚胺重复单元和任选的一个或多个酸性基团，X是含有可聚合双键并与 A的氮原子，其中每个X可以相同或不同并且由下式（2）表示：其中R 1和R 2彼此独立并且表示氢原子，C 1-6烷基或 基团 - （CH 2）m -COOM，其中M表示氢原子或金属原子，m为0至6的整数，L为键或C 1-6亚烷基; 并且n是至少为1的整数; （ii）引发剂体系; 任选的多酸聚合物; 任选地水和/或水溶性溶剂; 和任选的颗粒填料。