公开(公告)号：EP1454911A1

公开(公告)日：2004-09-08

申请号：EP03005174.2

申请日：2003-03-07

申请人： DENTSPLY DETREY GmbH

发明人： Klee, Joachim, E ,  Lehmann, Uwe ,  Walz, Uwe ,  Liu, Huaibing

IPC分类号： C07F9/09 ,  A61K6/08 ,  C08F30/02

CPC分类号： A61K6/083 ,  A61K6/0023 ,  C07F9/091 ,  C07F9/093 ,  C08F30/02 ,  C08L43/02 ,  C08L33/00

摘要： The present invention provides a polymerizable phosphoric acid ester derivative having the following formula (A):
   wherein
      Z is COOR 1 , COSR 1 , CON(R 1 ) 2 , CONR 1 R 2 , CONHR 1 , or CN,
      R 1 and R 2 independently are a hydrogen atom, a substituted or unsubstituted C 1 to C 18 alkyl group optionally substituted by a C 3 to C 8 cycloalkyl group, a substituted or unsubstituted C 3 to C 8 cycloalkyl group, a substituted or unsubstituted C 4 to C 18 aryl or heteroaryl group, a substituted or unsubstituted C 5 to C 18 alkylaryl or alkylheteroaryl group, or a substituted or unsubstituted C 7 to C 30 aralkyl group, whereby two R 1 residues may form together with the N-atom to which they are bonded a 5- to 7-membered heterocyclic ring which may contain beside said N-atom a further nitrogen atom or an oxygen atom, and whereby the substituted groups may be substituted by 1 to 5 C 1 to C 5 alkyl group(s);
       a is an integer of from 1 to 10, preferably 1 to 5;
       b is an integer of from 1 to 10, preferably 1 to 5; and
      R represents an organic residue containing a + b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said carbon atoms linking a phosphate or 2-(oxa-ethyl)acryl derivative group.

摘要翻译： 本发明提供具有下式（A）的可聚合磷酸酯衍生物：其中Z为COOR1，COSR1，CON（R1）2，CONR1R2，CONHR1或CN的，R1和R2独立地为氢原子， 任选被C 3至C 8环烷基取代的取代或未取代的C 1至C 18烷基，取代或未取代的C 3至C 8环烷基，取代或未取代的C 4至C 18芳基或杂芳基，取代或未取代的C 5至C 18烷基芳基或 烷基杂芳基或取代或未取代的C7至C30芳烷基，其中两个R 1残基可以与它们所键合的N-原子一起形成5-7元杂环，其可以在所述N-原子旁边另外含有 氮原子或氧原子，并且由此取代的基团可以被1至5个C 1 -C 5烷基取代; a为1〜10的整数，优选为1〜5; b为1〜10的整数，优选为1〜5; R表示含有选自伯和仲脂族碳原子，仲脂环族碳原子和芳香族碳原子的+ b个碳原子的有机残基，所述碳原子连接磷酸酯或2-（氧杂 - 乙基）丙烯酰基衍生物基团 。