公开(公告)号：EP2755980A4

公开(公告)日：2015-06-03

申请号：EP12832249

申请日：2012-09-14

申请人： DOW AGROSCIENCES LLC

发明人： MENNING CATHERINE A ,  BLAYLOCK D WAYNE ,  EMONDS MARK V M

IPC分类号： C07F5/02 ,  B01J8/06 ,  B01J19/24 ,  C07F1/02

CPC分类号： C07F5/025 ,  B01J19/0093 ,  B01J19/24 ,  B01J2219/00011 ,  B01J2219/0004 ,  B01J2219/00094 ,  B01J2219/00099 ,  B01J2219/00795 ,  B01J2219/00813 ,  B01J2219/00822 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00894

摘要： Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a 1-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The 1-chloro-2-substituted-3-fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed.

公开(公告)号：EP2797890A4

公开(公告)日：2015-09-23

申请号：EP12862450

申请日：2012-12-28

申请人： DOW AGROSCIENCES LLC

发明人： OPPENHEIMER JOSSIAN ,  EMONDS MARK V M ,  DERSTINE CHRISTOPHER W ,  CLOUSE ROBERT C

IPC分类号： C07D213/803 ,  C07F5/02

CPC分类号： C07D213/803 ,  C07F5/025