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1.发明授权Hydrolases, nucleic acids encoding them and mehods for making and using them 有权水解酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：EP2853593B1
公开(公告)日：2017-10-04
申请号：EP14187967.6
申请日：2004-03-08
申请人： DSM IP Assets B.V.
CPC分类号： C12N9/20 , A23C9/20 , A23C19/05 , A23C19/063 , A23K10/14 , A23K20/189 , A23L29/06 , A23V2002/00 , A61K8/0216 , A61K8/375 , A61K8/606 , A61K8/66 , A61K38/465 , A61K2800/86 , A61Q5/06 , A61Q11/00 , A61Q19/00 , C10M129/70 , C10M129/76 , C10M2207/281 , C10M2207/289 , C10M2207/40 , C11C3/08 , C11D3/386 , C11D3/38627 , C11D3/38636 , C12C1/047 , C12C5/004 , C12C11/003 , C12N9/14 , C12N9/16 , C12N9/18 , C12P7/6418 , C12Q1/34 , C12Y301/01003 , D06M16/003 , D06M2200/12 , D06M2200/30 , D06M2200/50 , G01N33/573 , G01N2500/02
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2.发明公开Hydrolases, nucleic acids encoding them and mehods for making and using them 有权水解酶，核酸编码它们和制备方法以及它们的使用
公开(公告)号：EP2853593A1
公开(公告)日：2015-04-01
申请号：EP14187967.6
申请日：2004-03-08
申请人： DSM IP Assets B.V.
CPC分类号： C12N9/20 , A23C9/20 , A23C19/05 , A23C19/063 , A23K10/14 , A23K20/189 , A23L29/06 , A23V2002/00 , A61K8/0216 , A61K8/375 , A61K8/606 , A61K8/66 , A61K38/465 , A61K2800/86 , A61Q5/06 , A61Q11/00 , A61Q19/00 , C10M129/70 , C10M129/76 , C10M2207/281 , C10M2207/289 , C10M2207/40 , C11C3/08 , C11D3/386 , C11D3/38627 , C11D3/38636 , C12C1/047 , C12C5/004 , C12C11/003 , C12N9/14 , C12N9/16 , C12N9/18 , C12P7/6418 , C12Q1/34 , C12Y301/01003 , D06M16/003 , D06M2200/12 , D06M2200/30 , D06M2200/50 , G01N33/573 , G01N2500/02
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.
摘要翻译： 本发明提供水解酶，多核苷酸编码它们，以及制备和使用这些多核苷酸和多肽的方法。 在一个方面，本发明涉及多肽，例如酶，其具有水解酶活性，例如，以酯酶，酰基转移酶，脂肪酶，磷脂酶（例如磷脂酶A，B，C和D活性，patatin启动活性，脂质酰基水解酶（ LAH）活性）或蛋白酶活性，包括热电表和耐热水解酶活性，和多核苷酸编码合成的酶，以及制备和使用这些多核苷酸和多肽。 所述多肽的本发明的水解酶活性和肽包括酯酶活性，脂肪酶活性（脂质的水解），酸解反应（在酯化脂肪酸以游离脂肪酸，以取代），酯交换反应（的甘油三酯之间脂肪酸交换） 酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。 本发明的多肽可以在多种药物，农业和工业环境中，包括化妆品和营养保健品的制造中的使用。 在另一个方面，本发明的多肽被用于合成对映异构体纯的手性产物。
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