公开(公告)号：EP2200981A1

公开(公告)日：2010-06-30

申请号：EP08840109.6

申请日：2008-10-02

申请人： DSM IP Assets B.V.

发明人： SARAKINOS, Georgios ,  LANGE, DE, Ben

IPC分类号： C07D209/52 ,  C07C275/18 ,  C07C273/18 ,  C07C229/28

CPC分类号： C07D209/52 ,  C07C275/18

摘要： The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine derivatives.

摘要翻译： 本发明涉及氨基甲酰甘氨酸衍生物，制备氨基甲酰甘氨酸衍生物的方法以及氨基甲酰甘氨酸衍生物在制备对映体富集的α-氨基酸中的用途。 此外，本发明涉及使用新型氨基甲酰甘氨酸衍生物制备药物活性产物，例如培哚普利和雷米普利。

公开(公告)号：EP2225200B1

公开(公告)日：2013-10-16

申请号：EP08865851.3

申请日：2008-12-19

申请人： DSM IP Assets B.V.

发明人： LANGE, DE, Ben ,  CASTELIJNS, Anna, Maria, Cornelia, Francisca ,  VRIES, DE, Johannes, Gerardus ,  VRIES DE, Andreas, Hendrikus, Maria ,  BOOGERS, Jeroen, Antonius, Franciscus ,  BROXTERMAN, Quirinus, Bernardus

IPC分类号： C07C231/18 ,  C07C237/22 ,  C07C43/225 ,  C07C69/716 ,  C07D307/32 ,  C07F1/02 ,  C07F7/18

CPC分类号： C07D307/33 ,  C07C231/02 ,  C07C231/18 ,  C07D307/32 ,  C07F1/02 ,  C07F7/1856 ,  C07C237/22

公开(公告)号：EP2225200A1

公开(公告)日：2010-09-08

申请号：EP08865851.3

申请日：2008-12-19

申请人： DSM IP Assets B.V.

发明人： LANGE, DE, Ben ,  CASTELIJNS, Anna, Maria, Cornelia, Francisca ,  VRIES, DE, Johannes, Gerardus ,  VRIES DE, Andreas, Hendrikus, Maria ,  BOOGERS, Jeroen, Antonius, Franciscus ,  BROXTERMAN, Quirinus, Bernardus

IPC分类号： C07C231/18 ,  C07C237/22 ,  C07C43/225 ,  C07C69/716 ,  C07D307/32 ,  C07F1/02 ,  C07F7/18

CPC分类号： C07D307/33 ,  C07C231/02 ,  C07C231/18 ,  C07D307/32 ,  C07F1/02 ,  C07F7/1856 ,  C07C237/22

摘要： Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3_6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).

公开(公告)号：EP2344455A1

公开(公告)日：2011-07-20

申请号：EP09741304.1

申请日：2009-10-27

申请人： DSM IP Assets B.V.

发明人： LANGE, DE, Ben ,  HEEMSKERK, Dennis

IPC分类号： C07D209/52

CPC分类号： C07D209/52

摘要： The present invention relates to a process for the preparation of octahydrocyclopenta[b]pyrrole-2-carboxylic acid and esters thereof of general formula (1) in the presence of a cobalt and/or nickel comprising catalyst and to the use of compounds of general formula (1) in the synthesis of ramipril.

公开(公告)号：EP2150538A2

公开(公告)日：2010-02-10

申请号：EP08760425.2

申请日：2008-06-03

申请人： DSM IP Assets B.V.

发明人： SARAKINOS, Georgios ,  BOESTEN, Wilhelmus Hubertus Joseph ,  HEEMSKERK, Dennis ,  LANGE, DE, Ben

IPC分类号： C07D233/80 ,  C07D209/42 ,  C07D209/52

CPC分类号： C07D209/42 ,  C07D209/52 ,  C07D233/76 ,  C07D233/78 ,  C07D233/80

摘要： The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins.

公开(公告)号：EP2200981B1

公开(公告)日：2011-12-07

申请号：EP08840109.6

申请日：2008-10-02

申请人： DSM IP Assets B.V.

发明人： SARAKINOS, Georgios ,  LANGE, DE, Ben

IPC分类号： C07D209/52 ,  C07C275/18 ,  C07C273/18 ,  C07C229/28

CPC分类号： C07D209/52 ,  C07C275/18

摘要： The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine derivatives.