专利检索 ap:("DSM N.V.") AND inv:"DE PATER, Robertus, Mattheus" 第 1 页

1.

发明授权
ENZYMATIC SYNTHESIS OF CERAMIDES AND HYBRID CERAMIDES 失效
标题翻译：神经酰胺和混合神经酰胺的酶法合成

公开(公告)号：EP0651817B1

公开(公告)日：2000-09-20

申请号：EP94916945.2

申请日：1994-05-06

申请人： DSM N.V.

发明人： SMEETS, Jan, Willem, Hubert , DE PATER, Robertus, Mattheus , LAMBERS, Johannes, Wilhelmus, Jacobus

IPC分类号： C12P13/02 , C07C233/18 , A61K7/48

CPC分类号： C12P13/02 , Y10S514/844 , Y10S514/847

2.

发明公开
HMG-CoA REDUCTASE INHIBITOR PREPARATION PROCESS 失效
标题翻译：用于生产HMG-CoA还原酶抑制剂

公开(公告)号：EP0980437A1

公开(公告)日：2000-02-23

申请号：EP98925525.2

申请日：1998-05-04

申请人： DSM N.V.

发明人： SIBEIJN, Mieke , BOUMAN, Andrianus, Johannes , DE PATER, Robertus, Mattheus , PURMER, Cornelis, Frederik

IPC分类号： C12P7/62 , C07C69/732 , C07C67/317

CPC分类号： C12P7/62 , C07C67/56 , C07C67/58 , C07D309/30 , C07C69/732

摘要： A process for preparing a compound which is hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor (such as lovastatin, compactin or pravastatin), or a precursor thereof, is disclosed where a broth containing the inhibitor (or its precursor) resulting from fermentation is basified prior to filtration to remove the biomass. The resulting filtrate is contacted with an adsorbent resin, acidified and the compound extracted using toluene, in which it is subsequently lactonized to give the inhibitor. The toluene containing the compound is then washed twice, firstly with alkaline, and then secondly with acidified water, before being isolated by crystallisation.

3.

发明公开
ISOLATION OF CAROTENOID CRYSTALS FROM MICROBIAL BIOMASS 失效
标题翻译：类胡萝卜素晶体脱离土壤微生物生物量

公开(公告)号：EP0979302A1

公开(公告)日：2000-02-16

申请号：EP98922804.4

申请日：1998-04-29

申请人： DSM N.V.

发明人： SIBEIJN, Mieke , DE PATER, Robertus, Mattheus

IPC分类号： C12P23/00 , C07C403/24

CPC分类号： C07C403/24 , C12P23/00

摘要： The present invention describes a process for the direct isolation of a crystalline carotenoid compound from microbial biomass. With the process of the invention, the use of large amounts of solvent necessary to solubilize the carotenoid when applying a conventional extraction process is circumvented.

4.

发明授权
SELECTIVE PROCESS FOR THE DEACYLATION OF ACYLATED COMPOUNDS 失效
标题翻译：选择性PROCESS FOR酰基化合物的脱酰

公开(公告)号：EP0784605B1

公开(公告)日：2000-02-16

申请号：EP96928423.1

申请日：1996-08-05

申请人： DSM N.V.

发明人： DE PATER, Robertus, Mattheus , SIBEYN, Mieke

IPC分类号： C07C69/732 , C07C67/317 , C12P7/62

CPC分类号： C12P7/62 , C12P17/06

摘要： The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.