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公开(公告)号：EP0651817B1
公开(公告)日：2000-09-20
申请号：EP94916945.2
申请日：1994-05-06
申请人： DSM N.V.
发明人： SMEETS, Jan, Willem, Hubert , DE PATER, Robertus, Mattheus , LAMBERS, Johannes, Wilhelmus, Jacobus
IPC分类号： C12P13/02 , C07C233/18 , A61K7/48
CPC分类号： C12P13/02 , Y10S514/844 , Y10S514/847
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公开(公告)号：EP0966431A1
公开(公告)日：1999-12-29
申请号：EP98916997.0
申请日：1998-03-13
申请人： DSM N.V.
CPC分类号： A61K8/68 , A61K8/42 , A61Q19/00 , A61Q19/08 , C07C235/60
摘要： The present invention discloses novel compounds which are derivatives of salicylic acid and a sphingoid base of formula (1), wherein salicylic acid and the sphingoid base are coupled via an amide linkage. The present invention further describes topical use of said novel compounds.
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公开(公告)号：EP0706509B1
公开(公告)日：2000-01-05
申请号：EP95917976.3
申请日：1995-04-27
申请人： DSM N.V.
IPC分类号： C07C235/08 , A61K7/48 , A61K7/06
CPC分类号： A61Q19/00 , A61K8/68 , A61K2800/75 , A61Q17/00 , C07C235/08
摘要： The present invention relates to active ceramide derivatives. Specifically, the invention relates to 2(alpha)-hydroxycarboxylic acid-based ceramide derivatives. The present invention describes a method for obtaining these compounds. The invention also relates to the use of these compounds in cosmetic compositions.
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4.发明公开COMPOSITIONS COMPRISING A COMBINATION OF A FREE SPHINGOID BASE AND A CERAMIDE AND USES THEREOF 有权成分含有游离的组合鞘氨醇碱和神经酰胺及其用途
公开(公告)号：EP0975325A1
公开(公告)日：2000-02-02
申请号：EP98963566.9
申请日：1998-12-07
申请人： DSM N.V.
IPC分类号： A61K7/48
CPC分类号： A61K8/68 , A61K8/41 , A61Q17/00 , A61Q19/00 , A61Q19/007
摘要： The present invention discloses a composition for topical use comprising a free sphingoid base and a ceramide. The compositions of the invention are suitable for application to skin conditions associated with an impaired barrier function, in particular to skin conditions further associated with a deranged regulation of cell growth and differentiation, an inflammatory condition and/or an infectious state.
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公开(公告)号：EP0789686B1
公开(公告)日：2000-02-02
申请号：EP96931002.8
申请日：1996-09-02
申请人： DSM N.V.
IPC分类号： C07C403/18 , A61K31/07 , A61K31/20 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/671 , A61K8/68 , A61K2800/57 , C07C403/20 , C07C2601/16 , Y10S514/844
摘要： The present invention relates to active derivatives of sphingoid bases. Specifically, the invention relates to retinoylamide based derivatives of sphingoid bases. The present invention describes a method for obtaining these compounds. The invention also relates to the use of these compounds in compositions for topical use.
摘要翻译： PCT No.PCT / EP96 / 03848 Sec。 371日期1997年04月21日 102（e）日期1997年4月21日PCT 1996年9月2日PCT公布。 第WO97 / 09307号公报 日期1997年3月13日本发明涉及类鞘氨醇碱的活性衍生物。 具体地，本发明涉及类鞘氨醇碱基的视黄酰胺基衍生物。 本发明描述了获得这些化合物的方法。 本发明还涉及这些化合物在化妆品组合物中的用途。
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