公开(公告)号：EP4053122A1

公开(公告)日：2022-09-07

申请号：EP20882583.6

申请日：2020-10-29

申请人： Daegu-Gyeongbuk Medical Innovation Foundation

发明人： YU, Ji-Hoon ,  IM, Chun Young ,  KIM, So Young ,  HAN, Ye Ri ,  LEE, Doohyun ,  JEON, Hui-Jeon ,  MIN, Sang-Hyun ,  OH, Bae Jun ,  PARK, Sang-Wook ,  CHOI, Dong-Kyu ,  KIM, Young-Kyu ,  KIM, Sung Hwan ,  LEE, Yuri ,  LEE, Seungyeon ,  KIM, Nam Hui ,  KIM, Sang Bum ,  MIN, Ju-Sik

IPC分类号： C07D405/14 ,  C07D405/12 ,  A61K31/496 ,  A61P35/00

摘要： The present invention relates to a compound comprising an EZH2 inhibitor and an E3 ligase binder, and a pharmaceutical composition for preventing or treating EZH2-associated disease and a pharmaceutical composition for selective protein degradation containing the same as an active ingredient. Since the compound of the present invention can selectively degrade EZH2, it can be effectively used for the treatment of EZH2-related diseases and cancers, particularly, cancers in which EZH2 is overexpressed, and can be usefully used for the selective degradation of EZH2.

公开(公告)号：EP4083037A1

公开(公告)日：2022-11-02

申请号：EP20906363.5

申请日：2020-12-22

申请人： Yonsei University, University-Industry Foundation(UIF). ,  Daegu-Gyeongbuk Medical Innovation Foundation

发明人： KIM, Youngsoo ,  SHIN, Jisu ,  HONG, Ki Bum ,  YU, Ji Hoon ,  LEE, Ji Hoon ,  KIM, Da Rong ,  JEON, Hui-Jeon ,  SONG, Jaeyoung ,  PARK, Jin Wan ,  LEE, Ju Suk ,  LEE, Won Seok ,  KIM, Young-Kyu ,  KIM, Sung Hwan ,  YOON, Heeseok

IPC分类号： C07D417/06 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4178 ,  C07D277/36 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D471/04 ,  A61P25/28

摘要： Provided are: a novel pyrrolidine derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same and having the effects of inhibiting beta-amyloid and/or tau protein aggregation, and/or breaking down beta-amyloid and/or tau protein aggregates, and/or preventing and/or treating beta-amyloid and/or tau protein-associated diseases.