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公开(公告)号：EP4159726A1
公开(公告)日：2023-04-05
申请号：EP21813774.3
申请日：2021-05-25
发明人： SONG, Minsoo , PARK, Ga Young , KO, Eun Bi , KANG, Jihee , IM, Chun Young , BAE, Seri , KIM, Soong-Hyun , PARK, Yoojin , LEE, Eunhye , CHOI, Yujeong , KIM, Sang Bum , KWON, Oh-Bin , SHIN, Chan Young , KWON, Kyoung Ja , PAUDEL, Suresh , JEON, Se Jin , CHO, Kyu Suk
IPC分类号： C07D401/06 , A61K31/454 , A61K31/496 , A61P25/00 , A61P25/18 , C07D403/06 , C07D401/14 , A23L33/10
摘要： The present invention relates to a 5-membered heteroaryl derivative containing an N, and a pharmaceutical composition for use in preventing or treating mental disorders, containing same as an active ingredient, wherein the derivative is excellent in the triple reuptake inhibitory effect of serotonin, norepinephrine, and dopamine, and thus can be useful in the treatment of mental disorders.
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公开(公告)号：EP4159718A1
公开(公告)日：2023-04-05
申请号：EP21814082.0
申请日：2021-04-05
发明人： SONG, Minsoo , IM, Chun Young , PARK, Ga Young , KO, Eun Bi , KANG, Jihee , BAE, Seri , KIM, Soong-Hyun , PARK, Yoojin , LEE, Eunhye , CHOI, Yujeong , JOO, Jeongmin , LEE, Sion , SHIN, Chan Young , KWON, Kyoung Ja , HWANG, Hee Jong , PAUDEL, Suresh , JEON, Se Jin , CHO, Kyu Suk
IPC分类号： C07D211/34 , A61K31/445 , A61K31/454 , A61P25/00 , A23L33/10 , A61P25/18 , C07D401/04
摘要： Disclosed are a sulfonamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.
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公开(公告)号：EP4065553A1
公开(公告)日：2022-10-05
申请号：EP21741012.5
申请日：2021-01-15
发明人： IM, Chun Young , MIN, Sang Hyun , YU, Ji Hoon , KO, Eun Bi , KIM, So Young , LEE, Seungyeon , CHOI, Dong Kyu , LEE, Heejin , PARK, Ga Young , LEE, Doohyun , HONG, Eunmi , JEON, Hui-Jeon , PARK, Young-Hoon , HAN, Ye Ri , KIM, Nam Hui , KIM, Jun Woo , OH, Bae Jun , PARK, Jeong-Eun , SEO, Chang Hoon , SONG, Minsoo , RO, Seonggu , SHIN, Dongkyu
IPC分类号： C07C311/16 , C07C303/36 , A61K31/18 , A61P35/00 , A61P29/00 , A61P3/00 , A23L33/10
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公开(公告)号：EP4159725A1
公开(公告)日：2023-04-05
申请号：EP21812765.2
申请日：2021-04-05
发明人： SONG, Minsoo , IM, Chun Young , PARK, Ga Young , KO, Eun Bi , KANG, Jihee , BAE, Seri , KIM, Soong-Hyun , PARK, Yoojin , LEE, Eunhye , CHOI, Yujeong , CHA, Eunju , SEO, Chang Hoon , SHIN, Chan Young , KWON, Kyoung Ja , MABUNGA, Darine Froy , PARK, Donghyun , HWANG, Hee Jong , KIM, Ryeong Eun , PAUDEL, Suresh , JEON, Se Jin , CHO, Kyu Suk
IPC分类号： C07D295/13 , A61K31/495 , A61K31/4439 , A61P25/00 , A61P25/18 , C07D211/18 , C07D401/04 , A23L33/10
摘要： Disclosed are a carboxamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.
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公开(公告)号：EP4105217A1
公开(公告)日：2022-12-21
申请号：EP21761078.1
申请日：2021-02-26
发明人： LEE, Doohyun , LEE, Seungyeon , HAN, Ye Ri , IM, Chun Young , KIM, So Young , KIM, Nam Hui , CHOI, Hwan Geun , KO, Eunhwa , MOON, Heegyum , LEE, Sun Joo , KIM, Sang Bum , KIM, Hyo-Ji , LEE, Sion , AHN, Sung-Min , CHANG, Kiho , LEE, Eunkyu , KWON, Hyun Jin , JEONG, Myeong-Sook , KIM, Ji Young
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61P35/00 , A23L33/10
摘要： The present invention relates to a 3-((8-((1H-pyrazol-4-yl)amino)imidazo[1,2-a]pyridin-3-yl)ethynyl)-N-phenylbenzamide derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer. The derivative can significantly inhibit the proliferation of cancer cells by inhibiting kinases, particularly Bcr-Abl kinase or Bcr-Abl (T315I) kinase. Therefore, the derivative can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer.
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公开(公告)号：EP4053122A1
公开(公告)日：2022-09-07
申请号：EP20882583.6
申请日：2020-10-29
发明人： YU, Ji-Hoon , IM, Chun Young , KIM, So Young , HAN, Ye Ri , LEE, Doohyun , JEON, Hui-Jeon , MIN, Sang-Hyun , OH, Bae Jun , PARK, Sang-Wook , CHOI, Dong-Kyu , KIM, Young-Kyu , KIM, Sung Hwan , LEE, Yuri , LEE, Seungyeon , KIM, Nam Hui , KIM, Sang Bum , MIN, Ju-Sik
IPC分类号： C07D405/14 , C07D405/12 , A61K31/496 , A61P35/00
摘要： The present invention relates to a compound comprising an EZH2 inhibitor and an E3 ligase binder, and a pharmaceutical composition for preventing or treating EZH2-associated disease and a pharmaceutical composition for selective protein degradation containing the same as an active ingredient. Since the compound of the present invention can selectively degrade EZH2, it can be effectively used for the treatment of EZH2-related diseases and cancers, particularly, cancers in which EZH2 is overexpressed, and can be usefully used for the selective degradation of EZH2.
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