公开(公告)号：EP3949987A1

公开(公告)日：2022-02-09

申请号：EP20778080.0

申请日：2020-03-24

申请人： Daiichi Sankyo Company, Limited

发明人： HARADA Naoya ,  YONEDA Kozo ,  HAYAKAWA Ichiro

IPC分类号： A61K39/395 ,  A61K45/00 ,  A61P35/00 ,  C07K1/22 ,  C07K7/06 ,  C07K7/08 ,  C07K16/28 ,  C07K16/46 ,  C12N5/10 ,  A61K47/68 ,  C12N15/13 ,  C12N15/63 ,  A61K31/4192 ,  A61K31/551 ,  C12P21/08

摘要： A novel anti-HER2 antibody-pyrrolobenzodiazepine (PBD) derivative conjugate, a medicine having therapeutic effect against tumor with the antibody-drug conjugate, and a method for treating a tumor by using the antibody-drug conjugate or medicine.

公开(公告)号：EP3882349A1

公开(公告)日：2021-09-22

申请号：EP19884507.5

申请日：2019-11-13

申请人： Daiichi Sankyo Company, Limited

发明人： SAITO Atsuko ,  HARADA Naoya ,  YONEDA Kozo ,  HAYAKAWA Ichiro ,  MEGURO Masaki ,  DOI Fuminao

IPC分类号： C12N15/13 ,  A61K39/395 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/63 ,  C12P21/08

摘要： An object of the present invention is to provide an antibody specifically binding to CDH6 and having a high internalization activity, an antibody-drug conjugate comprising the antibody and a high antitumor activity, a pharmaceutical product having the antibody-drug conjugate and having a therapeutic effect on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like.
According to the present invention, it is possible to provide an anti-CDH6 antibody prepared having internalization activity, an anti-CDH6 antibody-drug conjugate prepared by connecting the anti-CDH6 antibody and a novel PBD derivative and exhibiting high anti-tumor activity, a pharmaceutical product and a therapeutic method for treating tumors using these.

公开(公告)号：EP3690038A1

公开(公告)日：2020-08-05

申请号：EP18862011.6

申请日：2018-09-28

申请人： Daiichi Sankyo Company, Limited

发明人： TODA Narihiro ,  OTA Yusuke ,  DOI Fuminao ,  MEGURO Masaki ,  HAYAKAWA Ichiro ,  ASHIDA Shinji ,  MASUDA Takeshi ,  NAKADA Takashi ,  IWAMOTO Mitsuhiro ,  HARADA Naoya ,  TERAUCHI Tomoko ,  OKAJIMA Daisuke ,  NAKAMURA Kensuke ,  UCHIDA Hiroaki ,  HAMADA Hirofumi

IPC分类号： C12N15/06 ,  A61K31/5513 ,  A61K35/00 ,  A61K39/395 ,  A61K47/68 ,  C07D487/04 ,  C07K16/00 ,  C07K16/30 ,  C12N5/10 ,  C12P21/08

摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.