公开(公告)号：EP3690038A1

公开(公告)日：2020-08-05

申请号：EP18862011.6

申请日：2018-09-28

申请人： Daiichi Sankyo Company, Limited

发明人： TODA Narihiro ,  OTA Yusuke ,  DOI Fuminao ,  MEGURO Masaki ,  HAYAKAWA Ichiro ,  ASHIDA Shinji ,  MASUDA Takeshi ,  NAKADA Takashi ,  IWAMOTO Mitsuhiro ,  HARADA Naoya ,  TERAUCHI Tomoko ,  OKAJIMA Daisuke ,  NAKAMURA Kensuke ,  UCHIDA Hiroaki ,  HAMADA Hirofumi

IPC分类号： C12N15/06 ,  A61K31/5513 ,  A61K35/00 ,  A61K39/395 ,  A61K47/68 ,  C07D487/04 ,  C07K16/00 ,  C07K16/30 ,  C12N5/10 ,  C12P21/08

摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

公开(公告)号：EP4209506A1

公开(公告)日：2023-07-12

申请号：EP21864357.5

申请日：2021-09-01

申请人： Daiichi Sankyo Company, Limited

发明人： NISHIZAWA Hanako ,  ONO Yasunori ,  IWAMOTO Mitsuhiro

IPC分类号： C07K16/00 ,  C12N5/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/54 ,  C12N15/56 ,  C12N15/63 ,  C12N9/10 ,  C12N9/24 ,  C12P21/02 ,  C12P21/08

摘要： The present invention provides endo-β-N-acetylglucosaminidase (Endo-Si) cloning from a strain belonging to Streptococcus iniae and a mutant enzyme thereof, a gene encoding the enzyme, a recombinant plasmid, a transformant obtained by transformation of a cell by the plasmid and use thereof, and a method for producing e.g., a sugar chain remodeled antibody using the enzyme. A polypeptide having an amino acid sequence at amino acid positions 34 to 928 in SEQ ID NO: 2 or an amino acid sequence having the same amino acid sequence except containing one or mutations at more amino acid positions selected from the group consisting of amino acids at position 241 (D241), 190 (T190), 311 (Q311) and 360 (E360), said polypeptide exhibiting a sugar chain hydrolysis activity and/or transglycosylation activity.

公开(公告)号：EP4029520A1

公开(公告)日：2022-07-20

申请号：EP20863189.5

申请日：2020-09-09

申请人： Daiichi Sankyo Company, Limited

发明人： KOIZUMI Makoto ,  IWAMOTO Mitsuhiro ,  SEKIGUCHI Yukiko ,  ITO Kentaro

IPC分类号： A61K48/00 ,  A61P1/00 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P27/02 ,  A61P31/04 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C12N5/10 ,  A61K47/54 ,  C12N15/113 ,  C12N15/87 ,  A61K31/7088

摘要： The present invention provides a conjugate of an oligonucleotide having a nucleic acid sequence expected to have a pharmacological effect in hepatic parenchymal cells with a biantennary GalNAc unit, or a pharmaceutically acceptable salt thereof, and a medicament or the like containing the same as an active component.