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公开(公告)号：EP4253546A2
公开(公告)日：2023-10-04
申请号：EP23176351.7
申请日：2014-09-19
申请人： National Institutes of Biomedical Innovation, Health and Nutrition , Daiichi Sankyo Company, Limited
发明人： ISHII, Ken , KOBIYAMA, Kouji , AOSHI, Taiki , TAKESHITA, Fumihiko , KASUYA, Yuji , NIWA, Takako , KOIZUMI, Makoto
IPC分类号： C12N15/117
摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.
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公开(公告)号：EP4253546A3
公开(公告)日：2023-12-13
申请号：EP23176351.7
申请日：2014-09-19
申请人： National Institutes of Biomedical Innovation, Health and Nutrition , Daiichi Sankyo Company, Limited
发明人： ISHII, Ken , KOBIYAMA, Kouji , AOSHI, Taiki , TAKESHITA, Fumihiko , KASUYA, Yuji , NIWA, Takako , KOIZUMI, Makoto
IPC分类号： A61P31/04 , A61P31/12 , A61K31/7125 , A61K31/713 , A61K39/02 , A61K39/12 , A61K39/39 , A61P33/00 , A61P35/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07H21/04 , C12N15/09
摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.
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公开(公告)号：EP4059515A1
公开(公告)日：2022-09-21
申请号：EP20887577.3
申请日：2020-11-13
申请人： Daiichi Sankyo Company, Limited , National Institutes of Biomedical Innovation, Health and Nutrition
发明人： NIWA, Takako , SUZUKI, Takashi , KOIZUMI, Makoto , JONAI, Nao , ONODERA, Yoshikuni , TAKESHITA, Fumihiko , ISHII, Ken
IPC分类号： A61K39/12 , A61K48/00 , A61P31/20 , A61P35/00 , A61K9/14 , A61K9/50 , A61K47/18 , A61K47/24 , A61K47/28 , A61K47/34 , A61K47/54 , C12N15/37 , C12N15/62 , C12N15/63 , C12N15/88
摘要： The present invention provides a vaccine for preventing and/or treating infections with human papillomavirus. The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the E6 and E7 antigens of human papillomavirus, wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof:
wherein R 1 and R 2 each independently represent a C 1 -C 3 alkyl group;
L 1 represents a C 17 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups;
L 2 represents a C 10 -C 19 alkyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups or a C 10 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups; and
p is 3 or 4.-
公开(公告)号：EP3048170B1
公开(公告)日：2019-07-31
申请号：EP14846493.6
申请日：2014-09-19
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5.发明公开COMPLEX CONTAINING OLIGONUCLEOTIDE HAVING IMMUNOPOTENTIATING ACTIVITY AND USE THEREOF 审中-公开与免疫激活作用及其用途寡核苷酸复合物
公开(公告)号：EP3048170A1
公开(公告)日：2016-07-27
申请号：EP14846493.6
申请日：2014-09-19
发明人： ISHII, Ken , KOBIYAMA, Kouji , AOSHI, Taiki , TAKESHITA, Fumihiko , KASUYA, Yuji , NIWA, Takako , KOIZUMI, Makoto
IPC分类号： C12N15/09 , A61K31/7125 , A61K31/713 , A61K39/02 , A61K39/12 , A61K39/39 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07H21/04
CPC分类号： C12N15/117 , A61K31/7125 , A61K31/713 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/39 , A61K2039/5252 , A61K2039/55561 , A61K2039/55583 , C07H21/04 , C08B37/0024 , C12N7/00 , C12N2310/17 , C12N2310/315 , C12N2310/351 , C12N2310/3519 , C12N2320/31 , C12N2760/16134 , C12N2760/18534
摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.
摘要翻译： 本发明提供一种脱氧腺苷酸到含有人源化的K型的CpG寡脱氧核苷酸和聚，聚worin的脱氧腺苷酸放置在人源化K型的CpG寡脱氧核苷酸的3“侧的寡脱氧核苷酸。 此外，本发明提供了一种复合物含有上述寡核苷酸和²-1,3-葡聚糖。
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公开(公告)号：EP4166158A1
公开(公告)日：2023-04-19
申请号：EP21821552.3
申请日：2021-06-10
发明人： KAWAOKA, Yoshihiro , IMAI, Masaki , YAMAYOSHI, Seiya , ISHII, Ken , KOBIYAMA, Kouji , NAMBA, Eiko , OKA, Tatsuya , TOZUKA, Miyuki , JONAI, Nao , ONODERA, Yoshikuni , TAKESHITA, Fumihiko , SUZUKI, Takashi , NIWA, Takako , KOIZUMI, Makoto , NAKAMURA, Kensuke
IPC分类号： A61K39/00 , A61K39/215 , A61K48/00 , A61P31/12 , A61P31/14 , C07K14/165 , A61K9/107 , A61K9/14 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/28 , C12N15/50 , C12N15/88 , A61K31/7105
摘要： The present invention provides a vaccine for preventing and/or treating infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the S protein and/or a fragment thereof of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof
wherein R 1 and R 2 each independently represent a C 1 -C 3 alkyl group;
L 1 represents a C 17 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups;
L 2 represents a C 10 -C 19 alkyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups or a C 10 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups; and
p is 3 or 4.-
公开(公告)号：EP4252757A1
公开(公告)日：2023-10-04
申请号：EP21891939.7
申请日：2021-11-11
发明人： ISHII, Ken , KUSAKABE, Takato , KASUYA, Yuji , JONAI, Nao , TAKESHITA, Fumihiko , TANAKA, Isshin , KUROSAWA, Emi , SUZUKI, Kyosuke , KOGA, Tetsufumi , MIYAJI, Yoshihiro
IPC分类号： A61K31/7088 , A61K31/716 , A61K47/61 , A61K48/00 , A61P35/00 , C12N15/11
摘要： A complex of β(1→3) glucan and a nucleic acid, and having a controlled particle size is provided by the present invention. Furthermore, a complex of β(1→3) glucan and a nucleic acid, and having a controlled particle size is provided by the present invention.
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