公开(公告)号：EP4166158A1

公开(公告)日：2023-04-19

申请号：EP21821552.3

申请日：2021-06-10

申请人： Daiichi Sankyo Company, Limited ,  The University of Tokyo

发明人： KAWAOKA, Yoshihiro ,  IMAI, Masaki ,  YAMAYOSHI, Seiya ,  ISHII, Ken ,  KOBIYAMA, Kouji ,  NAMBA, Eiko ,  OKA, Tatsuya ,  TOZUKA, Miyuki ,  JONAI, Nao ,  ONODERA, Yoshikuni ,  TAKESHITA, Fumihiko ,  SUZUKI, Takashi ,  NIWA, Takako ,  KOIZUMI, Makoto ,  NAKAMURA, Kensuke

IPC分类号： A61K39/00 ,  A61K39/215 ,  A61K48/00 ,  A61P31/12 ,  A61P31/14 ,  C07K14/165 ,  A61K9/107 ,  A61K9/14 ,  A61K47/14 ,  A61K47/18 ,  A61K47/24 ,  A61K47/28 ,  C12N15/50 ,  C12N15/88 ,  A61K31/7105

摘要： The present invention provides a vaccine for preventing and/or treating infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the S protein and/or a fragment thereof of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof

wherein R 1 and R 2 each independently represent a C 1 -C 3 alkyl group;
L 1 represents a C 17 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups;
L 2 represents a C 10 -C 19 alkyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups or a C 10 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups; and
p is 3 or 4.

公开(公告)号：EP4253546A2

公开(公告)日：2023-10-04

申请号：EP23176351.7

申请日：2014-09-19

申请人： National Institutes of Biomedical Innovation, Health and Nutrition ,  Daiichi Sankyo Company, Limited

发明人： ISHII, Ken ,  KOBIYAMA, Kouji ,  AOSHI, Taiki ,  TAKESHITA, Fumihiko ,  KASUYA, Yuji ,  NIWA, Takako ,  KOIZUMI, Makoto

IPC分类号： C12N15/117

摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.

公开(公告)号：EP4253546A3

公开(公告)日：2023-12-13

申请号：EP23176351.7

申请日：2014-09-19

申请人： National Institutes of Biomedical Innovation, Health and Nutrition ,  Daiichi Sankyo Company, Limited

发明人： ISHII, Ken ,  KOBIYAMA, Kouji ,  AOSHI, Taiki ,  TAKESHITA, Fumihiko ,  KASUYA, Yuji ,  NIWA, Takako ,  KOIZUMI, Makoto

IPC分类号： A61P31/04 ,  A61P31/12 ,  A61K31/7125 ,  A61K31/713 ,  A61K39/02 ,  A61K39/12 ,  A61K39/39 ,  A61P33/00 ,  A61P35/00 ,  A61P37/04 ,  A61P37/08 ,  A61P43/00 ,  C07H21/04 ,  C12N15/09

摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.

公开(公告)号：EP4059515A1

公开(公告)日：2022-09-21

申请号：EP20887577.3

申请日：2020-11-13

申请人： Daiichi Sankyo Company, Limited ,  National Institutes of Biomedical Innovation, Health and Nutrition

发明人： NIWA, Takako ,  SUZUKI, Takashi ,  KOIZUMI, Makoto ,  JONAI, Nao ,  ONODERA, Yoshikuni ,  TAKESHITA, Fumihiko ,  ISHII, Ken

IPC分类号： A61K39/12 ,  A61K48/00 ,  A61P31/20 ,  A61P35/00 ,  A61K9/14 ,  A61K9/50 ,  A61K47/18 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/54 ,  C12N15/37 ,  C12N15/62 ,  C12N15/63 ,  C12N15/88

摘要： The present invention provides a vaccine for preventing and/or treating infections with human papillomavirus. The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the E6 and E7 antigens of human papillomavirus, wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof:

wherein R 1 and R 2 each independently represent a C 1 -C 3 alkyl group;
L 1 represents a C 17 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups;
L 2 represents a C 10 -C 19 alkyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups or a C 10 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups; and
p is 3 or 4.

公开(公告)号：EP4252757A1

公开(公告)日：2023-10-04

申请号：EP21891939.7

申请日：2021-11-11

申请人： Daiichi Sankyo Company, Limited

发明人： ISHII, Ken ,  KUSAKABE, Takato ,  KASUYA, Yuji ,  JONAI, Nao ,  TAKESHITA, Fumihiko ,  TANAKA, Isshin ,  KUROSAWA, Emi ,  SUZUKI, Kyosuke ,  KOGA, Tetsufumi ,  MIYAJI, Yoshihiro

IPC分类号： A61K31/7088 ,  A61K31/716 ,  A61K47/61 ,  A61K48/00 ,  A61P35/00 ,  C12N15/11

摘要： A complex of β(1→3) glucan and a nucleic acid, and having a controlled particle size is provided by the present invention. Furthermore, a complex of β(1→3) glucan and a nucleic acid, and having a controlled particle size is provided by the present invention.