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公开(公告)号：EP1350511B1
公开(公告)日：2008-09-10
申请号：EP01271850.8
申请日：2001-12-20
IPC分类号： A61K31/4365 , A61K31/60
CPC分类号： A61K45/06 , A61K31/4365 , A61K31/60 , A61K31/616 , A61K2300/00
摘要： Medicinal compositions containing as the active ingredients 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or its pharmacologically acceptable salt and aspirin. Because of having excellent inhibitory effects on platelet aggregation and thrombosis, these compositions are useful as preventives or remedies for diseases induced by thrombus or embolization.
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2.发明授权PROCESS FOR PRODUCING HIGH-PURITY PRASUGREL HYDROCHLORIDE 有权VERFAHREN ZUR HERSTELLUNG VON HOCHREINEM PRASUGREL HYDROCHLORID
公开(公告)号：EP2003136B1
公开(公告)日：2017-01-18
申请号：EP07741221.1
申请日：2007-04-06
发明人： INOUE, Teruhiko , NAKAMURA, Kazuyoshi , HAGIHARA, Masahiko , MIYATA, Hiroyuki , WADA, Yukinori , YOKOTA, Naoyuki
IPC分类号： C07D495/04 , A61K31/4365 , A61P7/02
CPC分类号： C07D495/04
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3.发明公开
公开(公告)号：EP2003136A1
公开(公告)日：2008-12-17
申请号：EP07741221.1
申请日：2007-04-06
发明人： INOUE, Teruhiko , NAKAMURA, Kazuyoshi , HAGIHARA, Masahiko , MIYATA, Hiroyuki , WADA, Yukinori , YOKOTA, Naoyuki
IPC分类号： C07D495/04 , A61K31/4365 , A61P7/02
CPC分类号： C07D495/04
摘要： The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.
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公开(公告)号：EP1063230A1
公开(公告)日：2000-12-27
申请号：EP99906508.9
申请日：1999-02-26
发明人： ASAI, Fumitoshi , SUGIDACHI, Atsuhiro, Sankyo Comp.,ltd. , IKEDA, Toshihiko, Sankyo Company, Limited , IWABUCHI, Haruo, Sankyo Company, Limited , KUROKI, Yoshiaki , INOUE, Teruhiko , IWAMURA, Ryo , SHIBAKAWA, Nobuhiko
IPC分类号： C07D205/08 , C07D207/12 , C07D211/52 , C07D211/72 , C07D471/08 , A61K31/395 , A61K31/40 , A61K31/445
CPC分类号： C07D471/08 , C07D205/04 , C07D207/12 , C07D211/52 , C07D211/54 , C07D211/72
摘要： Cyclic amino compounds represented by general formula (I) or pharmacologically acceptable salts thereof having an excellent antiplatelet aggregation effect; etc. and thus being useful as preventives or remedies for embolism, thrombosis or arterial sclerosis wherein R 1 represents optionally substituted phenyl; R 2 represents optionally substituted aliphatic acyl, optionally substituted benzoyl or alkoxycarbonyl; and R 3 represents substituted and optionally ring-fused saturated cyclic amino.
摘要翻译： 由通式（I）表示的环状氨基化合物或其药理学上可接受的盐具有优异的抗血小板聚集作用; 因此可用作栓塞，血栓形成或动脉硬化症的预防剂或治疗剂，其中R 1表示任选取代的苯基; R 2表示任选取代的脂族酰基，任选取代的苯甲酰基或烷氧基羰基; R 3表示取代的和任选稠环的饱和环状氨基。
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5.发明公开
公开(公告)号：EP1350511A1
公开(公告)日：2003-10-08
申请号：EP01271850.8
申请日：2001-12-20
IPC分类号： A61K31/4365 , A61K31/616 , A61P7/02
CPC分类号： A61K45/06 , A61K31/4365 , A61K31/60 , A61K31/616 , A61K2300/00
摘要： [Subject]
Pharmaceutical compositions comprising 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, as active ingredients.
[Effect]
The pharmaceutical compositions of the present invention possess excellent inhibitory activity against platelet aggregation and thrombogenesis, and are useful for preventing or treating diseases caused by thrombus or embolus.摘要翻译： 包含2-乙酰氧基-5-（α-环丙基羰基-2-氟苄基）-4,5,6,7-四氢噻吩并[3,2-c]吡啶或其药学上可接受的盐和作为活性成分的阿司匹林的药物组合物。 本发明的药物组合物对血小板聚集和血栓形成具有优异的抑制活性，可用于预防或治疗由血栓或栓塞引起的疾病。
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公开(公告)号：EP1063230B1
公开(公告)日：2003-04-23
申请号：EP99906508.9
申请日：1999-02-26
发明人： ASAI, Fumitoshi , SUGIDACHI, Atsuhiro, Sankyo Comp.,ltd. , IKEDA, Toshihiko, Sankyo Company, Limited , IWABUCHI, Haruo, Sankyo Company, Limited , KUROKI, Yoshiaki , INOUE, Teruhiko , IWAMURA, Ryo , SHIBAKAWA, Nobuhiko
IPC分类号： C07D205/08 , C07D207/12 , C07D211/52 , C07D211/72 , C07D471/08 , A61K31/395 , A61K31/40 , A61K31/445
CPC分类号： C07D471/08 , C07D205/04 , C07D207/12 , C07D211/52 , C07D211/54 , C07D211/72
摘要： Cyclic amino compounds represented by general formula (I) or pharmacologically acceptable salts thereof having an excellent antiplatelet aggregation effect, etc. and thus being useful as preventives or remedies for embolism, thrombosis or arterial sclerosis wherein R1 represents optionally substituted phenyl; R2 represents optionally substituted aliphatic acyl, optionally substituted benzoyl or alkoxycarbonyl; and R3 represents substituted and optionally ring-fused saturated cyclic amino.
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