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8 条记录 (耗时 0.013 秒)

    PROCESS FOR PRODUCTION OF PRASUGREL HYDROCHLORIDE HAVING HIGH PURITY
    1.
    发明公开
    PROCESS FOR PRODUCTION OF PRASUGREL HYDROCHLORIDE HAVING HIGH PURITY 有权
    VERFAHREN ZUR HERSTELLUNG VON HOCHREINEM PRASUGRELHYDROCHLORID

    公开(公告)号：EP2123656A1

    公开(公告)日：2009-11-25

    申请号：EP08712139.8

    申请日：2008-02-29

    申请人： Daiichi Sankyo Company, Limited ,  Ube Industries, Ltd.

    发明人： MIYATA, Hiroyuki ,  WADA, Yukinori ,  YOKOTA, Naoyuki

    IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61P7/02

    CPC分类号： C07D495/04 ,  Y02P20/55

    摘要： An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like.

    In the formulae, R represents a protecting group for a hydroxyl group.
    A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.

    摘要翻译： 本发明的目的是提供具有降低的CATP含量的盐酸普拉格雷等。 式中，R表示羟基的保护基。 提供了一种制备由上式表示的盐酸普拉格雷盐酸盐的方法，其特征在于在步骤（i）中包括在低值时控制加入期间的温度，任选地滴加氯化剂和加入后的反应温度 ，任选地滴加氯化剂。

    METHOD FOR PRODUCING CARBAMATE COMPOUND
    6.
    发明公开
    METHOD FOR PRODUCING CARBAMATE COMPOUND 审中-公开
    VERFAHREN ZUR HERSTELLUNG EINER CARBAMATVERBINDUNG

    公开(公告)号：EP2325167A1

    公开(公告)日：2011-05-25

    申请号：EP09802909.3

    申请日：2009-07-27

    申请人： Ube Industries, Ltd.

    发明人： FUKUTA, Yukimasa ,  YAMAMOTO, Yasushi ,  MIYATA, Hiroyuki

    IPC分类号： C07C269/00 ,  C07C271/12 ,  C07C271/44 ,  C07B61/00

    CPC分类号： C07C269/00 ,  C07B41/12 ,  C07C2601/14 ,  C07C271/12 ,  C07C271/20

    摘要： A task of the present invention is to provide a process for preparation a carbamate compound using a carbonic acid ester and an amide compound in the presence of a basic compound(s), wherein the process is a novel industrial method which is advantageous in that the reaction rate is faster than conventional and the by-produced ester compound can be recovered, and the present invention is directed to a method comprising reacting an amide compound represented by the formula (1) with a carbonic acid ester represented by the formula (2) in the presence of a basic compound(s) to obtain a carbamate compound represented by the formula (3).

    摘要翻译： 本发明的任务是提供一种在碱性化合物存在下使用碳酸酯和酰胺化合物制备氨基甲酸酯化合物的方法，其中该方法是一种新的工业方法，其优点在于， 反应速度比常规速度快，可以回收副产的酯化合物，本发明涉及使式（1）表示的酰胺化合物与由式（2）表示的碳酸酯反应的方法， 在碱性化合物存在下，得到式（3）表示的氨基甲酸酯化合物。

    ASYMMETRICAL CARBONATE COMPOUND AND MANUFACTURING METHOD THEREOF
    7.
    发明公开
    ASYMMETRICAL CARBONATE COMPOUND AND MANUFACTURING METHOD THEREOF 有权
    VERFAHREN ZUR HERSTELLUNG不对称碳水化合物

    公开(公告)号：EP2253710A1

    公开(公告)日：2010-11-24

    申请号：EP09710722.1

    申请日：2009-02-16

    申请人： Ube Industries, Ltd.

    发明人： YAMAMOTO, Yasuhito ,  OKADA, Naoko ,  HIROTSU, Kenji ,  MIYATA, Hiroyuki ,  YAMAMOTO, Yasushi

    IPC分类号： C12P7/64 ,  C07C68/06 ,  C07C69/96

    CPC分类号： C12P7/6436 ,  C12P7/62

    摘要： This is to provide a process for preparing an asymmetric carbonate compound from a symmetric carbonate compound and an ester compound with good yield, which is simple and easy, and industrially suitable.
    Disclosed is a process for prepaing an asymmetric carbonate compound which comprises allowing a symmetric carbonate compound represented by the formula (1) to react with an ester compound represented by the formula (2) in the presence of a hydrolase.

    摘要翻译： 这是提供从对称碳酸酯化合物和酯化合物制备不对称碳酸酯化合物的方法，其具有良好的产率，这是简单和容易的以及在工业上合适的。 公开了一种制备不对称碳酸酯化合物的方法，其包括使式（1）所示的对称碳酸酯化合物在水解酶存在下与式（2）表示的酯化合物反应。