公开(公告)号：EP2092083A2

公开(公告)日：2009-08-26

申请号：EP07867262.3

申请日：2007-10-22

申请人： Dana-Farber Cancer Institute ,  DNAR, Inc ,  Oregon Health and Science University

发明人： D'ANDREA, Alan ,  WEAVER, David T. ,  GROMPE, Markus ,  KENNEDY, Richard

IPC分类号： C12Q1/68

CPC分类号： C12N15/1137 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2333/4716

摘要： This present invention relates compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound, specific for a DNA repair pathway. A method for treating cancer is provided, which includes: a) determining whether the cancer cell is deficient in a DNA repair pathway (eg. Fanconi anemia) and b) administering a DNA damaging agent or inhibitor specific for at least one different DNA repair pathway than that identified in step (a) (eg. mismatch repair or non-homologous endjoining repair pathways).

公开(公告)号：EP3433362A1

公开(公告)日：2019-01-30

申请号：EP17719049.3

申请日：2017-03-23

申请人： Dana-Farber Cancer Institute, Inc. ,  Oregon Health & Science University

发明人： D'ANDREA, Alan ,  GROMPE, Markus

IPC分类号： C12N15/10

公开(公告)号：EP1728077A2

公开(公告)日：2006-12-06

申请号：EP05756419.7

申请日：2005-01-28

申请人： DANA-FARBER CANCER INSTITUTE

发明人： D'ANDREA, Alan

IPC分类号： G01N33/53

CPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/5014 ,  G01N2800/52

摘要： The present invention discloses methods for detecting exposure of a living subject to genotoxic agents, testing sensitivity to a genotoxic agent, and determining DNA damage caused by exposure to an agent, comprising detecting the presence of FANCD2-containing foci from a sample collected from said subject. The presence of concentrated foci is indicative of DNA damage, and the degree of foci formation is correlated with degree of exposure. Diagnostic reagents contain a ligand that binds to human FANC~2 associated with a detectable label, Kits for detecting DNA damage in a biological sample contain such diagnostic reagents and signal detection components. The invention further discloses methods for identifying agents which modulate the ability of ~ANCD2-containing foci to form. Among other things, such agents are potentially useful chemosensitizing agents or may confer protection against damage caused by genotoxic agents.

公开(公告)号：EP3261647A1

公开(公告)日：2018-01-03

申请号：EP16710369.6

申请日：2016-02-25

申请人： Dana-Farber Cancer Institute, Inc.

发明人： D'ANDREA, Alan ,  PARMAR, Kalindi ,  ZHANG, Haojian

IPC分类号： A61K31/7088 ,  A61K39/00

CPC分类号： A61K31/7088 ,  A61K45/06 ,  C12N15/1135 ,  C12N2310/10 ,  C12N2310/14 ,  C12N2310/20 ,  C12N2310/531

摘要： The present invention provides methods of treating, preventing or delaying the onset of bone marrow failure in Fanconi Anemia patients.

公开(公告)号：EP3697767A1

公开(公告)日：2020-08-26

申请号：EP18868494.8

申请日：2018-10-16

申请人： Dana Farber Cancer Institute, Inc.

发明人： D'ANDREA, Alan ,  CECCALDI, Raphael ,  ZHOU, Jia

IPC分类号： C07D311/02 ,  C07D311/04

公开(公告)号：EP3703669A1

公开(公告)日：2020-09-09

申请号：EP18873193.9

申请日：2018-10-15

申请人： Dana-Farber Cancer Institute, Inc.

发明人： D'ANDREA, Alan ,  LIM, Kah Suan

IPC分类号： A61K31/00 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C12N5/09 ,  C12N15/113