专利检索 ap:("Dana-Farber Cancer Institute, Inc.") AND inv:"HATCHER, John" 第 1 页

1.

发明公开
INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF 审中-公开

公开(公告)号：EP3544970A1

公开(公告)日：2019-10-02

申请号：EP17817469.4

申请日：2017-11-22

申请人： Dana-Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. , ZHANG, Tinghu , HATCHER, John , BUHRLAGE, Sara, Jean

IPC分类号： C07D401/14 , C07D401/04 , C07D413/04 , A61K31/4439 , A61K31/444 , A61P35/00

2.

发明公开
PYRROLOPYRIMIDINE INHIBITORS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 审中-公开

公开(公告)号：EP3968990A1

公开(公告)日：2022-03-23

申请号：EP20804945.2

申请日：2020-05-15

申请人： Dana-Farber Cancer Institute, Inc. , Voronoi Inc.

发明人： GRAY, Nathanael S. , HATCHER, John , CHOI, Jieun , LEE, Sun-Hwa , CHOI, Hwangeun , KO, Eunhwa , KIM, Yeonsil , KIM, Daekwon , KIM, Namdoo , SON, Jungbeom

IPC分类号： A61K31/437 , C07D487/04 , A61P25/28

3.

发明公开
INHIBITORS OF MALT1 AND USES THEREOF 审中-公开

公开(公告)号：EP3592731A1

公开(公告)日：2020-01-15

申请号：EP18763780.6

申请日：2018-03-08

申请人： Cornell University , Dana Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. , SCOTT, David, A. , HATCHER, John , MELNICK, Ari, M. , GABAS, Lorena, Fontan

IPC分类号： C07D215/38 , C07D401/12

4.

发明公开
DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 审中-公开

公开(公告)号：EP3866801A1

公开(公告)日：2021-08-25

申请号：EP19873444.4

申请日：2019-10-16

申请人： Dana Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael S. , HATCHER, John

IPC分类号： A61K31/454

5.

发明公开
INHIBITORS OF ALK AND SRPK AND METHODS OF USE 审中-公开

公开(公告)号：EP3353150A1

公开(公告)日：2018-08-01

申请号：EP16849655.2

申请日：2016-09-23

申请人： Dana Farber Cancer Institute, Inc.

发明人： HATCHER, John , GRAY, Nathanael S. , CHOI, Hwan Geun , JANNE, Pasi , ZHANG, Tinghu

IPC分类号： C07D209/56 , C07D413/14 , A61K31/403 , A61K31/5377

CPC分类号： C07D209/80 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C12N9/12 , C12N9/96 , C12Y207/11001

摘要： which modulates the activity of ALK or SRPK, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which ALK or SRPK plays a role.

6.

发明公开
AZAINDOLE INHIBITORS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 审中-公开

公开(公告)号：EP3866809A1

公开(公告)日：2021-08-25

申请号：EP19874207.4

申请日：2019-10-16

申请人： Dana Farber Cancer Institute, Inc. , Voronoi Inc.

发明人： GRAY, Nathanael S. , HATCHER, John , CHOI, Jieun , CHOI, Hwangeun , KO, Eunhwa , KIM, Namdoo

IPC分类号： A61K31/541 , A61P11/00 , C07D471/04

7.

发明公开
LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME 审中-公开

公开(公告)号：EP3778605A2

公开(公告)日：2021-02-17

申请号：EP20194167.1

申请日：2016-02-12

申请人： Dana Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael S. , HATCHER, John , CHOI, Hwan, Geun

IPC分类号： C07D487/04 , C07D473/18 , A61K31/519 , A61P25/28

摘要： Compounds having the formula I, II, or III:

are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative diseases, such as Parkinson's Disease.

8.

发明公开
MALT1 INHIBITORS AND USES THEREOF 审中-公开

公开(公告)号：EP3341007A1

公开(公告)日：2018-07-04

申请号：EP16842694.8

申请日：2016-08-26

申请人： Cornell University , Dana-Farber Cancer Institute, Inc. , Children's Medical Center Corporation

发明人： GRAY, Nathanael, S. , MELNICK, Ari, M. , WU, Hao , SCOTT, David, A. , HATCHER, John , CHENNAMADHAVUNI, Spandan , GABAS, Lorena, Fontan , QIAO, Qi , DU, Guangyan

IPC分类号： A61K38/02 , A61K38/04 , A61K38/06 , C07K5/04 , C07K5/08 , C07K5/062

CPC分类号： C07K5/1019 , A61K38/00 , A61K38/07 , A61K45/06 , A61P35/02 , C07K5/04 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/08 , C07K5/101

摘要： Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

9.

发明公开
DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 AND USES THEREOF 审中-实审

公开(公告)号：EP4367115A1

公开(公告)日：2024-05-15

申请号：EP22838581.1

申请日：2022-07-07

申请人： Dana-Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael S. , HATCHER, John

IPC分类号： C07D401/14 , A61K31/506

CPC分类号： C07D401/14 , A61K31/506 , C07D417/14 , A61P25/16 , A61K47/55

10.

发明公开
LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME 审中-公开

公开(公告)号：EP3778605A3

公开(公告)日：2021-03-10

申请号：EP20194167.1

申请日：2016-02-12

申请人： Dana Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael S. , HATCHER, John , CHOI, Hwan, Geun

IPC分类号： C07D487/04 , C07D473/18 , A61K31/519 , A61P25/28

摘要： Compounds having the formula I, II, or III:

are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative diseases, such as Parkinson's Disease.