公开(公告)号：EP2222701A2

公开(公告)日：2010-09-01

申请号：EP08862950.6

申请日：2008-12-08

申请人： Dana-Farber Cancer Institute, Inc. ,  Burnham Institute for Medical Research

发明人： MARASCO, Wayne, A. ,  SUI, Jianhua ,  LIDDINGTON, Robert, C.

IPC分类号： C07K16/10 ,  A61K39/395 ,  G01N33/50

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/16122

摘要： The invention provides human scFv antibodies and monoclonal antibodies that neutralize influenza virus. Also provided are methods of treating and/or preventing a influenza related disease or disorder such as bird flu. The invention also provides methods of vaccinating a patient against influenza. Also provided are methods of diagnosing influenza- related diseases or disorders and methods of detecting the presence of a influenza in a sample.

摘要翻译： 本发明提供中和流感病毒的人scFv抗体和单克隆抗体。 还提供了治疗和/或预防流感相关疾病或病症的方法，例如禽流感本发明还提供了针对流感疫苗接种患者的方法。 还提供了诊断流感相关疾病或病症的方法以及检测样品中流感的存在的方法。

公开(公告)号：EP2222701B1

公开(公告)日：2017-11-01

申请号：EP08862950.6

申请日：2008-12-08

申请人： Dana-Farber Cancer Institute, Inc. ,  Burnham Institute for Medical Research

发明人： MARASCO, Wayne, A. ,  SUI, Jianhua ,  LIDDINGTON, Robert, C.

IPC分类号： C07K16/10 ,  A61K39/395 ,  G01N33/50

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/16122

摘要： The invention provides human scFv antibodies and monoclonal antibodies that neutralize influenza virus. Also provided are methods of treating and/or preventing a influenza related disease or disorder such as bird flu. The invention also provides methods of vaccinating a patient against influenza. Also provided are methods of diagnosing influenza- related diseases or disorders and methods of detecting the presence of a influenza in a sample.

公开(公告)号：EP2328928A2

公开(公告)日：2011-06-08

申请号：EP09791906.2

申请日：2009-08-25

申请人： Dana-Farber Cancer Institute, Inc. ,  Burnham Institute for Medical Research

发明人： MARASCO, Wayne, A. ,  SUI, Jianhua ,  LIDDINGTON, Robert, C.

IPC分类号： C07K16/10 ,  C07K14/11 ,  A61K39/145 ,  G01N33/50

CPC分类号： C07K16/1018 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/005 ,  C07K2299/00 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/40 ,  C12N2760/16022 ,  C12N2760/16034

摘要： Disclosed are antibodies that bind to the stem region of influenza hemagglutinin in the neutral pH conformation, hemagglutinin epitopes in the stem region, and methods of making and using both.

摘要翻译： 公开了结合中性pH构象的流感血凝素的茎区域的抗体，茎区域中的血凝素表位以及制造和使用两者的方法。