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1.发明授权SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE 有权小分子MYRISTATHEMMER BCR-ABL及使用方法有关
公开(公告)号：EP2222162B1
公开(公告)日：2016-11-16
申请号：EP08857261.5
申请日：2008-11-28
发明人： GRAY, Nathanael, S. , ZHANG, Jianming , OKRAM, Barun , DENG, Xianming , CHANG, Jae Won , WOJCIECHOWSKI, Amy
IPC分类号： C07D403/12 , C07D403/04 , C07D239/42 , C07D417/04 , C07D473/34 , C07D487/04 , C07D495/04 , A61K45/06 , A61K31/517 , C07D403/06 , C07D239/94 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , C07H19/16 , C07D471/04
CPC分类号： C07D487/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , C07D239/42 , C07D239/94 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04 , C07D473/34 , C07D495/04 , C07H19/16 , Y02A50/401
摘要： The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.
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公开(公告)号：EP3150593B8
公开(公告)日：2019-08-21
申请号：EP16197611.3
申请日：2008-11-28
IPC分类号： C07D403/12 , C07D403/04 , C07D403/06 , C07D239/42 , C07D239/94 , A61K45/06 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , C07D417/04 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07H19/16
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3.发明授权PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS 有权嘧啶二氮杂酮激酶支架化合物和治疗疾病的方法
公开(公告)号：EP2379559B1
公开(公告)日：2017-10-25
申请号：EP10729389.6
申请日：2010-01-06
IPC分类号： C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/04 , C07D513/04 , A61P35/00 , A61P29/00 , A61K31/4985 , A61K31/519
CPC分类号： C07D513/04 , C07C2601/08 , C07C2601/14 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS 1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1,2,3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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公开(公告)号：EP3738964A1
公开(公告)日：2020-11-18
申请号：EP20183712.7
申请日：2014-03-17
IPC分类号： C07D487/14 , C07D487/12 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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公开(公告)号：EP3388436A1
公开(公告)日：2018-10-17
申请号：EP18174175.2
申请日：2014-03-17
IPC分类号： C07D487/12 , C07D487/14 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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公开(公告)号：EP3828185A2
公开(公告)日：2021-06-02
申请号：EP21152496.2
申请日：2010-01-06
IPC分类号： C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/04 , C07D513/04 , A61P35/00 , A61P29/00 , A61K31/4985 , A61K31/519
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1,2,3, or 4, Ackl, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rskl, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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公开(公告)号：EP3388436B1
公开(公告)日：2020-08-12
申请号：EP18174175.2
申请日：2014-03-17
IPC分类号： C07D487/12 , C07D487/14 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
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公开(公告)号：EP2547661A2
公开(公告)日：2013-01-23
申请号：EP11713102.9
申请日：2011-02-18
发明人： GRAY, Nathanael , ZHOU, Wenjun , DENG, Xianming
IPC分类号： C07D231/56 , C07D401/10 , C07D403/12 , A61K31/416 , A61K31/496 , A61K31/4178 , A61K31/454 , A61P35/00
CPC分类号： A61K31/496 , A61K31/4184 , A61K45/06 , C07D231/56 , C07D401/10 , C07D403/12
摘要： The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.
摘要翻译： 本申请涉及治疗性有机化合物，包含有效量的治疗性有机化合物的组合物; 以及治疗和预防疾病的方法，包括向有需要的受试者施用和有效量的治疗性有机化合物。
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公开(公告)号：EP3670515A1
公开(公告)日：2020-06-24
申请号：EP20155968.9
申请日：2014-03-17
IPC分类号： C07D487/14 , C07D487/12 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
摘要： The present invention relates to novel pyrimido-diazepinone compounds of formula (I), methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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公开(公告)号：EP3828185A3
公开(公告)日：2021-09-01
申请号：EP21152496.2
申请日：2010-01-06
IPC分类号： C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/04 , C07D513/04 , A61P35/00 , A61P29/00 , A61K31/4985 , A61K31/519
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1,2,3, or 4, Ackl, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rskl, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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