公开(公告)号：EP2368495A2

公开(公告)日：2011-09-28

申请号：EP11170825.1

申请日：2003-05-19

申请人： Davies, Richard J.

发明人： Davies, Richard J.

IPC分类号： A61B5/053

CPC分类号： A61B5/4381 ,  A61B5/04002 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/4312 ,  A61B5/4839 ,  A61B5/6806 ,  A61B5/6834

摘要： A method and system are provided for determining a condition of a selected region of epithelial tissue. At least two current-passing electrodes are located in contact with a. first surface of the selected region of the tissue, A plurality of measuring electrodes are located in contact with the first surface of the selected region of tissue as well. Electropotential and impedance are measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.

摘要翻译： 提供了一种用于确定所选择的上皮组织区域的状况的方法和系统。 至少两个电流通过电极定位成与a接触。 组织的选定区域的第一表面，多个测量电极也位于与组织的选定区域的第一表面接触。 在一个或多个位置测量电位和阻抗。 可以将药剂引入组织区域以增强电生理特征。 基于上皮，组织或器官的不同深度处的电位和阻抗曲线，以及由于组织的离子迁移和电生理学性质的上皮细胞功能变化的估计，确定组织的状况。

公开(公告)号：EP1686894A2

公开(公告)日：2006-08-09

申请号：EP04811273.4

申请日：2004-11-17

申请人： Davies, Richard J.

发明人： Davies, Richard J.

IPC分类号： A61B5/05 ,  A61B5/02 ,  A61B5/08 ,  A61B8/00 ,  A61B8/14 ,  G01R27/00 ,  A61B8/12

CPC分类号： A61B5/053 ,  A61B5/04002 ,  A61B5/04085 ,  A61B5/05 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/4312 ,  A61B5/4381 ,  A61B5/4839 ,  A61B5/6806 ,  A61B5/6834

摘要： A method and system are provided for determining a condition of a selected region of tissue to facilitate the location of surgical resection margins. Electropotential and impedance are measured at one or more locations in an area of the body where tissue is to be removed. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics of that tissue. The condition of the tissue is measured by electropotential and impedance profile. Differences in the profile are used to determine the borders between normal and abnormal tissue so as to facilitate what tissue to resect. Methods and apparatus are also disclosed to determine the efficacy of various therapies.

公开(公告)号：EP1505906A1

公开(公告)日：2005-02-16

申请号：EP03731268.3

申请日：2003-05-19

申请人： Davies, Richard J.

发明人： Davies, Richard J.

IPC分类号： A61B5/05

CPC分类号： A61B5/4381 ,  A61B5/04002 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/4312 ,  A61B5/4839 ,  A61B5/6806 ,  A61B5/6834

摘要： A method and system are provided for determining a condition of a selected region of epithelial tissue. At least two current-passing electrodes are located in contact with a first surface of the selected region of the tissue. A plurality of measuring electrodes are located in contact with the first surface of the selected region of tissue as well. Electropotential and impedance are measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.

公开(公告)号：EP2368495A3

公开(公告)日：2012-04-04

申请号：EP11170825.1

申请日：2003-05-19

申请人： Davies, Richard J.

发明人： Davies, Richard J.

IPC分类号： A61B5/053

CPC分类号： A61B5/4381 ,  A61B5/04002 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/4312 ,  A61B5/4839 ,  A61B5/6806 ,  A61B5/6834

摘要： A method and system are provided for determining a condition of a selected region of epithelial tissue. At least two current-passing electrodes are located in contact with a. first surface of the selected region of the tissue, A plurality of measuring electrodes are located in contact with the first surface of the selected region of tissue as well. Electropotential and impedance are measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.

公开(公告)号：EP1686895A2

公开(公告)日：2006-08-09

申请号：EP04817833.9

申请日：2004-11-17

申请人： Davies, Richard J.

发明人： Davies, Richard J.

IPC分类号： A61B5/05

CPC分类号： A61B5/0531 ,  A61B5/04002 ,  A61B5/04082 ,  A61B5/4312 ,  A61B5/4839

摘要： A method and system are provided for determining a condition of a selected region of epithelial and stromal tissue in the human breast. A plurality of measuring electrodes (500) are used to measure the tissue and transepithelial electropotential of breast tissue. Surface electropotential and impedance are also measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.