公开(公告)号：EP3380484A1

公开(公告)日：2018-10-03

申请号：EP16819647.5

申请日：2016-11-25

申请人： Debreceni Egyetem

发明人： BOTÁR, Richárd ,  GARDA, Zoltán ,  FODOR, Tamás ,  KÁLMÁN, Ferenc Krisztián ,  NAGY, Viktória ,  TIRCSÓ, Gyula ,  TÓTH, Imre

IPC分类号： C07D498/08 ,  A61K31/439

CPC分类号： C07D498/08

摘要： The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(ll), Fe(ll), Fe(lll), Co(ll) and Ni(ll) complexes and their application: where R1| = - OH or -NR 3 R 4 amide functionality

公开(公告)号：EP3380473A1

公开(公告)日：2018-10-03

申请号：EP16819646.7

申请日：2016-11-25

申请人： Debreceni Egyetem

发明人： BOTÁR, Richárd ,  GARDA, Zoltán ,  FODOR, Tamás ,  KÁLMÁN, Ferenc Krisztián ,  NAGY, Victória ,  TIRCSÓ, Gyula ,  TÓTH, Imre

IPC分类号： C07D471/18 ,  A61K49/12 ,  A61K51/04

CPC分类号： C07D471/18 ,  A61K51/0472 ,  A61K51/0482 ,  A61K2123/00

摘要： The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds. The compounds of general formula (I): wherein -NRR1 group may refer to: a) -NRR1 with N atom in the ring means a ring of 4 to 7, that in certain cases may contain another heteroatom, and in specific cases the ring may be replaced with an aryl group (of 5 to 7 carbon atoms) substituted with -COOH, -OH, -OCH3, -NO2, -NH2, -NCS, -NHS- activated ester, aryl (of 5 to 7 carbon atoms), or nitro-, amino- or isothiocyanate group, or b) in the -NRR1 group R means a H atom, alkyl, aryl, nitroaryl, aminoaryl or isothiocyanate-aryl group (of 1 to 6 carbon atoms) and R4 is a H atom, alkyl (of 1 to 6 carbon atoms) or -(CH2)n-COOH group, whereas n=1 to 10 integer, or c) -NRR1 group is one of the following groups: (formula II) whereas R2 is a H atom, carboxyl- or alkyl-carbonyl group (of 1 to 4 carbon atoms);(formula III) and R2 is a H atom or alkyl or aryl group (of 1 to 6 carbon atoms), and X means independently from one another H atom, -CH3, -COOH, -OH, -OCH3, alkoxy- (of 2 to 6 carbon atoms), -NO2, -NH2, -NCS, -NHS -activated ester, alkyl (of 2 to 12 carbon atoms) or aryl (of 5 to 7 carbon atoms) group, in certain cases the latter may be substituted with hydroxyl, hydroxyalkyl (of 1 to 6 carbon atoms), nitro, amino or isothiocyanate group.

公开(公告)号：EP3380472A1

公开(公告)日：2018-10-03

申请号：EP16819645.9

申请日：2016-11-25

申请人： Debreceni Egyetem

发明人： BOTÁR, Richárd ,  GARDA, Zoltán ,  FODOR, Tamás ,  KÁLMÁN, Ferenc Krisztián ,  NAGY, Viktória ,  TIRCSÓ, Gyula ,  TÓTH, Imre

IPC分类号： C07D471/08 ,  A61K49/12 ,  A61K51/04

CPC分类号： A61K51/0485 ,  A61K2123/00 ,  C07D471/08

摘要： The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds. The compounds of general formula (I): wherein Ra refers to -OH group or -NR3R4 group and -NR3R4 group may refer to: a) -NR3R4 with N atom in the ring means a ring of 4 to 7, that in certain cases may contain another heteroatom, and in specific cases the ring may be replaced with an aryl group (of 5 to 7 carbon atoms) substituted with -COOH, -OH, -OCH3, -NO2, -NH2, -NCS, -NHS- activated ester, aryl (of 5 to 7 carbon atoms), or nitro-, amino- or isothiocyanate group, or b) in the -NR3R4 group R3 means a H atom, alkyl, aryl, nitroaryl, aminoaryl or isothiocyanate-aryl group (of 1 to 6 carbon atoms) and R4 is a H atom, alkyl (of 1 to 6 carbon atoms) or -(CH2)n-COOH group, whereas n=1 to 10 integer, or c) -NR3R4 group is one of the below groups: whereas R1 is a H atom, carboxyl or alkyl-carbonyl group (of 1 to 4 carbon atoms); and Rb is a H atom or alkyl group (of 1 to 6 carbon atoms), and X means independently from one another H atom, -CH3, -COOH, -OH, -OCH3, alkoxy- (of 2 to 6 carbon atoms), -NO2, -NH2, -NCS, -NHS-activated ester, alkyl (of 2 to 12 carbon atoms) or aryl (of 5 to 7 carbon atoms) group, in certain cases the latter may be substituted with hydroxyl, hydroxyalkyl (of 1 to 6 carbon atoms), nitro, amino or isothiocyanate group; and Y means: -NH- or >NCH2-Z group, whereas in the >CH2-Z group Z refers to one selected group of the below: -C(O)NR3R4 group, in which -NR3R4 means as referred to above, whereas z= 0- 18 integer, whereas z=0-18 integer, whereas z=0-18 integer, whereas z=0-18 integer and H atom, alkyl (of 1 to 6 carbon atoms) or -(CH2)n-COOH group, whereas n=l to 10 integer, or, whereas z= 0-18 integer, whereas z=0-18 integer and R2a refers to H atom, -OCH3, or -CF3 group, whereas R2b refers to H atom, -CH3, -OCH3>.CF3; - COOH, -COON(CO)2(CH2)2, -NO2, -NH2 or -NCS- group, whereas z= 0-18 integer and R2c refers to H atom, NO2, -NH2 or -NCS- group, whereas ζ=0-18, -and x=l-5 integer, whereas z=0-18,, and x=1.5 integer; whereas z=1-5, and x=1-5 integer, R2d refers to H atom, -CH3, -OCH3;.CF3, -COOH, - COON(CO)2(CH2)2, -NO2, -NH2 or -NCS group,