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公开(公告)号：EP0705278B1
公开(公告)日：2003-11-26
申请号：EP95909730.4
申请日：1995-02-16
发明人： KRAMMER, Peter , WESTENDORP, Michael , SCHULZE-OSTHOFF, Klaus , DEBATIN, Klaus-Michael , FRANK, Rainer , DHEIN, Jens , WALCZAK, Henning , KNIPPING, Eckart , STRICKER, Kirstin
IPC分类号： C07K14/715 , C07K16/28 , C12N15/62 , A61K39/395 , A61K39/42 , A61K38/17 , A61K38/55 , A61K31/37 , A61K31/70
CPC分类号： C07K16/2878 , A61K38/55 , A61K2039/505 , C07K14/70578 , C07K2317/54 , C07K2319/00 , C07K2319/30
摘要： The invention concerns an apoptose-inhibiting agent containing one, two or all of the following components: a) a compound which inhibits APO-1; b) a compound which inhibits or intercepts the APO-1 ligand; and c) a compound which inhibits the intra-cellular APO-1 signal path, the component(s) not being considered as foreign in an individual, plus the usual auxiliaries. The invention also concerns a compound, suitable for use in inhibiting apoptose, with at least one extra-cellular APO-1 domain and a carrier, the domain(s) and the carrier not being considered as foreign in an individual.
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公开(公告)号：EP1606318B1
公开(公告)日：2009-08-05
申请号：EP04723552.8
申请日：2004-03-26
发明人： WALCZAK, Henning
IPC分类号： C07K19/00 , C07K14/47 , C07K14/475 , C07K14/525 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/715
CPC分类号： C07K16/2875 , A61K2039/505 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2319/30
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3.发明公开
公开(公告)号：EP1530726A1
公开(公告)日：2005-05-18
申请号：EP03797246.0
申请日：2003-08-22
发明人： WALCZAK, Henning , SPRICK, Martin
IPC分类号： G01N33/68 , C12Q1/68 , G01N33/573
CPC分类号： C12Q1/37 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2333/96466
摘要： The present invention relates to a method of monitoring and/or modulating disease-associated activatory procceses which are mediated by caspase-10 or caspase-10 isoforms.
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公开(公告)号：EP1606318A2
公开(公告)日：2005-12-21
申请号：EP04723552.8
申请日：2004-03-26
发明人： WALCZAK, Henning
IPC分类号： C07K19/00 , C07K14/47 , C07K14/475 , C07K14/525 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/715
CPC分类号： C07K16/2875 , A61K2039/505 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2319/30
摘要： The invention relates to fusion proteins comprising at least a first domain and a second domain selected from a constant Fc immunoglobulin domain.
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公开(公告)号：EP0705278A1
公开(公告)日：1996-04-10
申请号：EP95909730.0
申请日：1995-02-16
发明人： KRAMMER, Peter , WESTENDORP, Michael , SCHULZE-OSTHOFF, Klaus , DEBATIN, Klaus-Michael , FRANK, Rainer , DHEIN, Jens , WALCZAK, Henning , KNIPPING, Eckart , STRICKER, Kirstin
IPC分类号： C12N15 , A61K38 , A61K39 , A61K45 , A61P31 , A61P43 , C07K14 , C07K16 , C07K19 , C12N9 , C12P21
CPC分类号： C07K16/2878 , A61K38/55 , A61K2039/505 , C07K14/70578 , C07K2317/54 , C07K2319/00 , C07K2319/30
摘要： The invention concerns an apoptose-inhibiting agent containing one, two or all of the following components: a) a compound which inhibits APO-1; b) a compound which inhibits or intercepts the APO-1 ligand; and c) a compound which inhibits the intra-cellular APO-1 signal path, the component(s) not being considered as foreign in an individual, plus the usual auxiliaries. The invention also concerns a compound, suitable for use in inhibiting apoptose, with at least one extra-cellular APO-1 domain and a carrier, the domain(s) and the carrier not being considered as foreign in an individual.
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