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    COMPOUNDS INHIBITING CD95 SIGNALING FOR THE TREATMENT OF PANCREATIC CANCER
    1.
    发明公开
    COMPOUNDS INHIBITING CD95 SIGNALING FOR THE TREATMENT OF PANCREATIC CANCER 审中-公开
    化合物FOR CD95-信号路径的胰腺癌的治疗抑制

    公开(公告)号：EP2502069A1

    公开(公告)日：2012-09-26

    申请号：EP10776734.5

    申请日：2010-11-15

    申请人： Deutsches Krebsforschungszentrum ,  Ruprecht-Karls-Universität Heidelberg

    发明人： MARTIN-VILALBA, Ana ,  HERHAUS, Peter ,  SANCHO-MARTINEZ, Ignacio ,  KLEBER, Susanne ,  WELSCH, Thilo

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5041 ,  A61K31/7105 ,  G01N33/5011 ,  G01N2333/70578

    摘要： The present invention is concerned with compounds inhibiting CD95 signaling in pancreatic cancer cells. Furthermore, contemplated by the current invention are medicaments comprising such a compound for the prevention and / or treatment of pancreatic cancer as well as the use of such a compound for the manufacture of a medicament for the prevention and / or treatment of pancreatic cancer, the prevention of migration of cancer cells, and / or the prevention and / or treatment of an inflammatory reaction. The present invention also refers to a method for the identification of a compound inhibiting CD95 signaling, as well as to a method for the manufacture of a medicament comprising the steps of the method for the identification of a compound inhibiting CD95 signaling and the further step of formulating the inhibiting compound as a medicament.

    摘要翻译： 本发明涉及的化合物抑制CD95在胰腺癌细胞中的信号传导。 进一步，由本发明考虑的是药物，其包含寻求胰腺癌的预防和/或治疗的化合物以及使用搜索的化合物在制备药物中的胰腺癌的预防和/或治疗，所述 预防癌细胞的迁移和/或预防和/或治疗炎性反应的。 因此，本发明涉及一种用于一化合物抑制CD95信号传导的识别的方法，以及一种用于药物，其包含该方法的步骤为的化合物抑制CD95信号传导的识别的制造和的进一步的步骤的方法 配制抑制的化合物作为药物的用途。