公开(公告)号：EP3129101A1

公开(公告)日：2017-02-15

申请号：EP15717429.3

申请日：2015-03-25

申请人： Universitätsklinikum Heidelberg

发明人： STREMMEL, Wolfgang

IPC分类号： A61P1/00

摘要： The present invention relates to the field of gastroenterology and, more particular, to the field of intestinal diseases. More specifically, it concerns uses and methods for the treatment of inflammatory bacterial diseases of the intestine. In particular, it relates to diseases that are associated with bacterial invasion of the intestinal mucus, including, inflammatory bowel diseases, and infectious bacterial diseases. Therefore, the present invention provides agents, a pharmaceutical composition and a kit for treating said diseases. It further relates to a use and a method for treating invasive bacterial diseases of the large intestine.

摘要翻译： 本发明涉及胃肠病学领域，更具体地涉及肠道疾病领域。 更具体地，涉及用于治疗肠道炎性细菌性疾病的用途和方法。 特别涉及与肠粘液的细菌侵袭有关的疾病，包括炎症性肠病和感染性细菌性疾病。 因此，本发明提供用于治疗所述疾病的药剂，药物组合物和试剂盒。 它还涉及用于治疗大肠侵袭性细菌性疾病的用途和方法。

公开(公告)号：EP2428252A1

公开(公告)日：2012-03-14

申请号：EP11190918.0

申请日：2007-12-28

申请人： Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts ,  Universitätsklinikum Heidelberg

发明人： Martin-Villalba, Ana ,  Kleber, Susanne ,  Wiestler, Benedikt ,  Krammer, Peter, G. ,  Herlod-Mende, Christel ,  Sancho-Martinez, Ignacio

IPC分类号： A61P35/00 ,  C07K16/28 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/566 ,  G01N33/57407 ,  G01N33/6863 ,  G01N2333/70578 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2510/00

摘要： The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue.

摘要翻译： 本发明涉及通过在体内预防或破坏CD95与其配体CD95L的结合来治疗具有高级胶质母细胞瘤多形性的个体的方法，因此中和CD95活性降低了不希望的胶质细胞迁移和侵入体内组织。

公开(公告)号：EP2419119A1

公开(公告)日：2012-02-22

申请号：EP10714584.9

申请日：2010-04-16

申请人： Universitätsklinikum Heidelberg

发明人： MOST, Patrick ,  VOELKERS, Mirko ,  KATUS, Hugo ,  REMPPIS, Andrew

IPC分类号： A61K38/17 ,  C07K14/47

CPC分类号： C07K14/4728 ,  A61K38/1709 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a peptide comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptide for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical composition comprising said peptide and a method for treating or preventing disorders associated with muscular malfunction using said peptide or said pharmaceutical composition.

公开(公告)号：EP2383577A1

公开(公告)日：2011-11-02

申请号：EP10004592.1

申请日：2010-04-30

申请人： Deutsches Krebsforschungszentrum ,  Ruprecht-Karls-Universität Heidelberg ,  Universitätsklinikum Heidelberg

发明人： Giese, Nathalia ,  Werner, Jens ,  Büchler, Markus ,  Giese, Thomas ,  Däffler, Laurent ,  Cziepluch, Celina ,  Rommelaere, Jan ,  Raykov, Zahari

IPC分类号： G01N33/574 ,  A61K35/76

CPC分类号： G01N33/68 ,  G01N33/57484

摘要： Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction of the expression or concentration of ISG15.

摘要翻译： 描述了一种用于预测患者的响应于chemovirotherapy或radiovirotherapy，包括：从患者暴露原发性肿瘤细胞，一种诊断方法例如脑瘤或胰腺癌，与（i）细小病毒和/或获得的肿瘤细胞（ⅱ ）化学治疗剂或放射疗法，和确定性采矿ISG15的表达或浓度的降低。

公开(公告)号：EP2326389A1

公开(公告)日：2011-06-01

申请号：EP09778501.8

申请日：2009-09-12

申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH ,  Siemens AG ,  Heidelberger Ionenstrahltherapie (Hit) Betriebs-Gesellschaft Am Universitätsklinikum Heidelberg MbH

发明人： BERT, Christoph ,  HABERER, Thomas ,  RIETZEL, Eike

IPC分类号： A61N5/10

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N2005/1085

摘要： The invention relates to a method for irradiating a target with a beam moving to a target point, comprising the following steps: measuring at least one of the variables relating to the position of the beam and intensity of the beam, changing the beam as a function of the at least one measured variable, particularly as a function of a variance relating to the at least one measured variable. The method is characterized in that per target point, the at least one measured variable is measured no more than once. The invention further relates to a device for irradiating a target according to the claimed method and to a control system for controlling a device of said kind.

公开(公告)号：EP2110079A1

公开(公告)日：2009-10-21

申请号：EP08154476.9

申请日：2008-04-14

申请人： DKFZ Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts ,  Universitätsklinikum Heidelberg ,  4D Concepts GmbH

发明人： Giesel, Frederik ,  Zechmann, Christian ,  von Tengg-Kobligk, Hendrik ,  Münter, Marc ,  Debus, Jürgen ,  Neumann, Rainer

IPC分类号： A61B6/03 ,  A61B19/00 ,  B29C67/00 ,  G06T17/00 ,  A61B5/00 ,  G01T1/00

CPC分类号： B28B1/001 ,  A61B34/10 ,  A61B2090/101 ,  A61F2/44 ,  A61F2002/30952 ,  A61N5/1049 ,  A61N2005/1097 ,  B29C64/165 ,  B29C64/386 ,  B29K2003/00 ,  B29L2031/753 ,  B33Y50/00 ,  B33Y80/00

摘要： The present invention relates to a method to derive anatomical and/or pathological structures (30) from non-invasive imaging technologies. Non-invasive imaging technologies are computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), surface scans and others. Imaging data obtained by non-invasive technology is used to create a surface contour (28). Said imaging data is transmitted to rapid prototyping apparatus readable data. At hand of this readable data said rapid prototyping apparatus establishes a positive or negative surface model (33), such as a fixation device, a mask or a prosthesis or other instruments for medical purposes.

摘要翻译： 本发明涉及一种方法来导出解剖和/或从非侵入性成像技术的病理结构（30）。 非侵入性成像技术计算机断层摄影（CT），磁共振成像（MRI），正电子发射断层摄影（PET）扫描表面及其它。 通过非侵入性技术获得的成像数据被用于创建的表面轮廓（28）。 所述成像数据是反式mitted快速原型设备可读的数据。 在这个可读数据的手所述快速原型制作设备建立一个正或负的表面模型（33）：如一个固定装置，掩模或假体或其他仪器用于医疗目的。

公开(公告)号：EP3863569A1

公开(公告)日：2021-08-18

申请号：EP19786747.6

申请日：2019-10-08

申请人： Endocon GmbH ,  Universitätsklinikum Heidelberg

发明人： MÜLLER, Ulrike ,  KRETZER, Jan Philippe ,  NOTARBARTOLO, Klaus ,  LINGSLEBE, Robert

IPC分类号： A61F2/46

公开(公告)号：EP3784253A1

公开(公告)日：2021-03-03

申请号：EP19727311.3

申请日：2019-05-17

申请人： TolerogenixX GmbH ,  Universitätsklinikum Heidelberg

发明人： MORATH, Christian. ,  SCHMITT, Anita. ,  SCHAIER, Matthias. ,  OPELZ, Gerhard. ,  TERNESS, Peter. ,  KLEIST, Christian. ,  DANIEL, Völker. ,  SÜSAL, Caner. ,  SCHMITT, Michael. ,  ZEIER, Martin.

IPC分类号： A61K35/15 ,  A61P37/06 ,  A61K31/407

公开(公告)号：EP2994768A1

公开(公告)日：2016-03-16

申请号：EP14720138.8

申请日：2014-04-29

申请人： Heidelberg Ionenstrahl-Therapie (HIT) Betriebs-Gesellschaft Am Universitätsklinikum Heidelberg MBH

发明人： FELDMEIER, Eike

IPC分类号： G01R33/00

CPC分类号： G01R33/02 ,  G01R33/0029 ,  G01R33/0035 ,  G01R33/0041 ,  G01R33/07 ,  H01J37/1472 ,  H01J2237/15

摘要： A device for the measuring and closed-loop control of a magnetic field generated by means of an electromagnet (5, 12, 15), comprising a first measuring device (10) for purposes of measuring the absolute magnetic field strength of the magnetic field, a second measuring device (11) for purposes of measuring the alteration of the magnetic field strength of the magnetic field, at least two integrators (20) for purposes of determining the magnetic field strength of the alteration of the magnetic field strength measured in the second measuring device (11), which integrators are arranged in parallel to one another, calibration means, a unit for purposes of comparing the magnetic field strength measured by the first measuring device (10) and the second measuring device (11), and a further unit for purposes of comparing the measured magnetic field strength with a prescribed design field strength, and a method.

摘要翻译： 一种用于测量和闭环控制借助于电磁体（5,12,15）产生的磁场的装置，包括用于测量磁场的绝对磁场强度的第一测量装置（10） 用于测量磁场的磁场强度变化的第二测量装置（11），至少两个积分器（20），用于确定在第二测量中测量的磁场强度变化的磁场强度 测量装置（11），所述积分器彼此平行地布置，校准装置，用于比较由第一测量装置（10）和第二测量装置（11）测量的磁场强度的单元，以及另外的 单元，用于将测得的磁场强度与规定的设计场强进行比较，以及一种方法。

公开(公告)号：EP2782928A1

公开(公告)日：2014-10-01

申请号：EP12851407.2

申请日：2012-11-21

申请人： The Royal Institution for the Advancement of Learning / McGill University ,  German Cancer Research Center (DKFZ) ,  Universitätsklinikum Heidelberg

发明人： JABADO, Nada ,  PFISTER, Stefan M. ,  PLASS, Christoph ,  KORSHUNOV, Andrey ,  WITT, Hendrik ,  STURM, Dominik ,  JONES, David ,  LICHTER, Peter ,  PFAFF, Elke

IPC分类号： C07K14/47 ,  A61K38/17 ,  A61P35/00 ,  C07K16/18 ,  C12N15/12 ,  C12Q1/00 ,  G01N33/574 ,  G01N33/68

CPC分类号： G01N33/57496 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/34 ,  C12Q1/6886 ,  G01N33/57407 ,  G01N33/6875 ,  G01N2500/00 ,  G01N2800/50 ,  G01N2800/56

摘要： The present application shows the relationship between variations in the amino acid sequence of histone proteins, more specifically the H3.3 protein, and proliferation-associated disorders. Herewith provided are predictive methods, commercial packages, therapeutic methods and screening methods based on this relationship.