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    LIQUID PHARMACEUTICAL COMPOSITION CONTAINING PIROXICAM AND HYALURONIC ACID FOR THE TREATMENT OF OSTEOARTHRITIS
    1.
    发明公开
    LIQUID PHARMACEUTICAL COMPOSITION CONTAINING PIROXICAM AND HYALURONIC ACID FOR THE TREATMENT OF OSTEOARTHRITIS 审中-公开
    液态药物组合物和透明质酸PIROXICAM用于治疗骨关节炎

    公开(公告)号：EP3007702A1

    公开(公告)日：2016-04-20

    申请号：EP14811288.1

    申请日：2014-05-27

    申请人： Dong-A ST Co., Ltd.

    发明人： KIM, Soon-Hoe ,  SON, Mi-Won ,  JANG, Sun-Woo ,  PARK, Chan-Woong ,  MA, Kyung-Wan ,  JUNG, Sang-Won

    IPC分类号： A61K31/54 ,  A61K31/728 ,  A61P19/02 ,  A61P19/00

    CPC分类号： A61K31/728 ,  A61K9/0019 ,  A61K31/5415 ,  A61K47/02 ,  A61K2300/00

    摘要： The present invention relates to the pharmaceutical composition for the treatment of osteoarthritis comprising piroxicam or pharmaceutically acceptable salt thereof and hyaluronic acid or pharmaceutically acceptable salt thereof at a specific ratio that generates synergistic effect on both anti-inflammatory and analgesic effects simultaneously. The present invention provides a pharmaceutical composition for the treatment of osteoarthritis comprising 0.25-10.0 wt% of piroxicam or its pharmaceutically acceptable salt and 0.5-5.0 wt% of hyaluronic acid or its pharmaceutically acceptable salt, where the weight ratio between piroxicam or its pharmaceutically acceptable salt and hyaluronic acid or its pharmaceutically acceptable salt is between 1:1 and 1:3. The liquid pharmaceutical composition according to the present invention has an outstanding therapeutic effect simultaneously on both inflammation and pain, thus providing an injectable formulation for intra-articular injection with synergistic effect on the treatment of osteoarthritis.

    摘要翻译： 提供了一种用于治疗骨关节炎的以特定的比例含有炎痛喜康或其药学上可接受的盐和透明质酸或其药学上可接受的盐的药物组合物。 该组合物基因率上同时在两个抗炎和镇痛作用的协同效果。 药物组合物含有炎痛喜康或其药学上可接受的盐和透明质酸或其药学上可接受的盐的0.5-5.0％（重量）的0.25-10.0％（重量），吡罗昔康worin或其药学上可接受的盐和透明质酸或其药学上可接受的盐之间的重量比 为1：1和1：3。

    STABLE PHARMACEUTICAL COMPOSITION COMPRISING PEMETREXED OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    4.
    发明公开
    STABLE PHARMACEUTICAL COMPOSITION COMPRISING PEMETREXED OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 审中-公开
    稳定的药物组合物，含有药物或药物可接受的盐

    公开(公告)号：EP3222271A1

    公开(公告)日：2017-09-27

    申请号：EP15860147.6

    申请日：2015-11-06

    申请人： Dong-A ST Co., Ltd.

    发明人： SOHN, Mi-Won ,  JANG, Sun-Woo ,  WON, Dong-Han ,  KIM, Yong-Min ,  HWANG, Hyung-Don ,  MIN, Dong-Hun

    IPC分类号： A61K9/08 ,  A61K47/02 ,  A61K47/18 ,  A61K31/519

    CPC分类号： A61K31/519 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/16 ,  A61K31/185 ,  A61K47/02 ,  A61K47/18

    摘要： The present invention relates to a composition of a ready-to-use injectable solution, comprising pemetrexed or pharmaceutically acceptable salts thereof, which comprises pemetrexed, sodium sulfite, and N-acetyl-L-cystein. With respect to use as an injectable preparation, the composition of a ready-to-use injectable solution comprising pemetrexed in accordance with the present invention is suitable for effective administration of pemetrexed since melting process of the main components before administration is not necessary, and the composition can be used by being diluted immediately in a perfusate. In addition, the properties of the composition do not change even in long-term storage, and pharmaceutical stability is significantly improved by inhibiting related substances below a standard, therefore the composition can be stored in a liquid preparation state.

    摘要翻译： 本发明涉及即用型可注射溶液的组合物，其包含培美曲塞或其药学上可接受的盐，其包含培美曲塞，亚硫酸钠和N-乙酰基-L-半胱氨酸。 关于用作可注射制剂，根据本发明的包含培美曲塞的即用型注射溶液的组合物适合有效施用培美曲塞，因为在给药之前主要组分的熔化过程不是必需的，并且 组合物可以通过立即在灌注液中稀释来使用。 另外，即使长期保存，组合物的性质也不会变化，通过将相关物质抑制在标准以下，药物稳定性显着提高，因此可以将液体制剂状态下的组合物保存。

    STABLE LIQUID PHARMACEUTICAL COMPOSITION CONTAINING PIROXICAM OR ITS PHARMACEUTICALLY ACCEPTABLE SALT AND HYALURONIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALT AND THE MANUFACTURING METHOD THEREOF
    7.
    发明公开
    STABLE LIQUID PHARMACEUTICAL COMPOSITION CONTAINING PIROXICAM OR ITS PHARMACEUTICALLY ACCEPTABLE SALT AND HYALURONIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALT AND THE MANUFACTURING METHOD THEREOF 审中-公开
    含PIROXICAM或其药学上可接受的盐和透明质酸或其药学上可接受的盐的稳定的液体药物组合物及其制造方法

    公开(公告)号：EP2822561A1

    公开(公告)日：2015-01-14

    申请号：EP13758220.1

    申请日：2013-03-07

    申请人： Dong-A ST Co., Ltd.

    发明人： KIM, Soon-Hoe ,  SON, Mi-Won ,  JANG, Sun-Woo ,  KANG, Myung-Joo ,  MA, Kyung-Wan

    IPC分类号： A61K31/54 ,  A61K31/728 ,  A61P29/00 ,  A61P25/00

    CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/5415 ,  A61K31/728 ,  A61K47/10 ,  A61K2300/00

    摘要： The present invention relates to a novel liquid composition comprised of piroxicam or its pharmaceutically acceptable salt (a non-steroid anti-inflammatory drug) and hyaluronic acid or its pharmaceutically acceptable salt (used for treatment of degenerative arthritis). Specifically, the invention provides a highly physicochemically stable liquid injection, comprising piroxicam and hyaluronic acid as active ingredients and β-cyclodextrin or its derivative and polyethylene glycol as additives to enhance its physicochemical stability, and the preparation method thereof. Therefore, the novel composition and the formulation method thereof provided by the present invention may be used to produce a liquid injection composition of piroxicam and hyaluronic acid.

    摘要翻译： 本发明涉及由吡罗昔康或其药学上可接受的盐（非类固醇抗炎药）和透明质酸或其药学上可接受的盐（用于治疗退行性关节炎）组成的新型液体组合物。 具体而言，本发明提供了一种高度物理化学稳定的液体注射剂及其制备方法，所述液体注射剂包含吡罗昔康和透明质酸作为活性成分并且β-环糊精或其衍生物和聚乙二醇作为添加剂以增强其物理化学稳定性。 因此，本发明提供的新型组合物及其制剂方法可用于制备吡罗昔康和透明质酸的液体注射组合物。