公开(公告)号：EP2092068B1

公开(公告)日：2014-10-08

申请号：EP07853356.9

申请日：2007-12-13

申请人： Dow AgroSciences LLC ,  Sangamo BioSciences, Inc.

发明人： CAI, Qihua C. ,  MILLER, Jeffrey ,  URNOV, Fyodor ,  SHUKLA, Vipula K. ,  PETOLINO, Joseph F. ,  BAKER, Lisa W. ,  GARRISON, Robbi J. ,  BLUE, Ryan C. ,  MITCHELL, Jon C. ,  ARNOLD, Nicole L. ,  WORDEN, Sarah E.

IPC分类号： C12N15/62 ,  C07K14/00 ,  C12N15/82 ,  C12N15/09

CPC分类号： C07K14/4702 ,  C07K2319/81 ,  C12N15/8213 ,  C12N15/8243

公开(公告)号：EP3070169A1

公开(公告)日：2016-09-21

申请号：EP16163183.3

申请日：2007-12-13

申请人： Dow AgroSciences, LLC ,  Sangamo BioSciences, Inc.

发明人： CAI, Qihua C. ,  MILLER, Jeffrey ,  URNOV, Fyodor ,  SHUKLA, Vipula K. ,  PETOLINO, Joseph F. ,  BAKER, Lisa W. ,  GARRISON, Robbi J. ,  BLUE, Ryan C. ,  MITCHELL, Jon C. ,  ARNOLD, Nicole L. ,  WORDEN, Sarah E.

IPC分类号： C12N15/62 ,  C07K14/00 ,  C12N15/82 ,  C12N15/09

CPC分类号： C07K14/4702 ,  C07K2319/81 ,  C12N15/8213 ,  C12N15/8243

摘要： Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also disclosed are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulations are also described.

摘要翻译： 本文公开了包含CCHC锌配位残基的锌指。 还公开了锌指蛋白和包含这些CCHC锌指的融合蛋白以及编码这些蛋白的多核苷酸。 还描述了使用这些蛋白质进行基因编辑和基因规则的方法。

公开(公告)号：EP2092068A2

公开(公告)日：2009-08-26

申请号：EP07853356.9

申请日：2007-12-13

申请人： Dow AgroSciences LLC ,  Sangamo BioSciences, Inc.

发明人： CAI, Qihua C. ,  MILLER, Jeffrey ,  URNOV, Fyodor ,  SHUKLA, Vipula K. ,  PETOLINO, Joseph F. ,  BAKER, Lisa W. ,  GARRISON, Robbi J. ,  BLUE, Ryan C. ,  MITCHELL, Jon C. ,  ARNOLD, Nicole L. ,  WORDEN, Sarah E.

IPC分类号： C12N15/62 ,  C07K14/00 ,  C12N15/82 ,  C12N15/09

CPC分类号： C07K14/4702 ,  C07K2319/81 ,  C12N15/8213 ,  C12N15/8243

摘要： Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described

公开(公告)号：EP3070169B1

公开(公告)日：2018-05-09

申请号：EP16163183.3

申请日：2007-12-13

申请人： Dow AgroSciences, LLC ,  Sangamo Therapeutics, Inc.

发明人： CAI, Qihua C. ,  MILLER, Jeffrey ,  URNOV, Fyodor ,  SHUKLA, Vipula K. ,  PETOLINO, Joseph F. ,  BAKER, Lisa W. ,  GARRISON, Robbi J. ,  BLUE, Ryan C. ,  MITCHELL, Jon C. ,  ARNOLD, Nicole L. ,  WORDEN, Sarah E.

IPC分类号： C12N15/62 ,  C07K14/00 ,  C12N15/82 ,  C12N15/09

CPC分类号： C07K14/4702 ,  C07K2319/81 ,  C12N15/8213 ,  C12N15/8243

摘要： Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.