公开(公告)号：EP2265605A1

公开(公告)日：2010-12-29

申请号：EP09722911.6

申请日：2009-03-18

申请人： Dr. Reddy's Laboratories, Ltd. ,  Dr. Reddy's Laboratories Ltd

发明人： KOLLA, Naveen, Kumar ,  MANNE, Nagaraju ,  GANGULA, Srinivas ,  NEELAM, Udaykumar ,  NAREDLA, Anitha ,  BADDAM, Sudhakar, Reddy ,  PATIL, Sumeet, Vishwasrao ,  TUMMALA, Arjunkumar ,  PEDDIREDDY, Subbareddy ,  SHINDE, Sachin, Gulabrao ,  SIGALA, Ashok ,  MUDUNURU, Satish Varma ,  TUMMIDI, Madhu, Kiran

IPC分类号： C07D403/12 ,  C07D235/28 ,  C07D235/24

CPC分类号： C07D401/12 ,  A61K9/1635 ,  A61K9/1652 ,  A61K47/6951 ,  B82Y5/00

摘要： Processes for the preparation of dexlansoprazole, an amorphous form of dexlansoprazole, a solid dispersion of amorphous dexlansoprazole and a pharmaceutically acceptable carrier, and processes for their preparation. Also provided are crystalline compounds 2-[(R)-[(4-chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and 2-[(R)-[(4-nitro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, and methods for their preparation.