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公开(公告)号：EP2895500A1
公开(公告)日：2015-07-22
申请号：EP13837551.4
申请日：2013-09-12
申请人： Duke University , Los Alamos National Security LLC , The Trustees Of The University Of Pennsylvania , Trustees of Boston University , The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services , The Board of Trustees of the Leland Stanford Junior University
发明人： HAYNES, Barton, F. , LIAO, Hua-Xin , LYNCH, Rebecca, M. , ZHOU, Tongqing , GAO, Feng , BOYD, Scott , SHAW, George, M. , HAHN, Beatrice, H. , KEPLER, Thomas, B. , KORBER, Bette, T. , KWONG, Peter , MASCOLA, John
IPC分类号： C07K14/155 , A61K39/12 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/15022 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
摘要翻译： 本发明一般涉及HIV-1，特别涉及广泛中和HIV-1抗体和HIV-1免疫原，以及涉及使用此类免疫原以诱导产生广泛中和HIV-1抗体的方法 主题（例如，人）。
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2.发明公开COMPOSITIONS COMPRISING CH848 ENVELOPES AND USES THEREOF 审中-公开ZUSAMMENSETZUNGEN MIT CH848-HÜLLPROTEINENUND VERWENDUNGEN DAVON
公开(公告)号：EP3126502A1
公开(公告)日：2017-02-08
申请号：EP15772335.4
申请日：2015-03-31
申请人： Duke University , The Trustees of The University of Pennsylvania , Los Alamos National Security, LLC
发明人： HAYNES, Barton, F. , HAHN, Beatrice, H. , SHAW, George, M. , KORBER, Bette, T. , HRABER, Peter, T.
IPC分类号： C12N15/49 , C07K14/155 , A61K31/7088 , A61K39/21
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/21 , A61K2039/70 , C07K14/155 , C12N2740/16034
摘要： In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
摘要翻译： 在某些方面，本发明提供包含CH848 HIV-1包膜的致突变组合物及其在受试者例如人受试者中诱导免疫应答的方法中的用途。
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3.发明公开COMPOSITIONS COMPRISING CH505 ENVELOPES, AND TRIMERS (EIGHT VALENT HIV-1 COMPOSITION AND METHODS) 审中-公开包含CH505包膜的组合物和修剪物（八价HIV-1组合物和方法）
公开(公告)号：EP3240559A1
公开(公告)日：2017-11-08
申请号：EP15873776.7
申请日：2015-12-23
CPC分类号： C07K14/005 , A61K35/76 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/6031 , C12N2740/16122 , C12N2740/16134
摘要： In certain aspects the invention provides a selection of HIV- 1 envelopes suitable for use as immunogens, and methods of using these immunogens in vaccination to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens and methods of using these comprise an immune modulating component.
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公开(公告)号：EP3423472A1
公开(公告)日：2019-01-09
申请号：EP17760739.7
申请日：2017-03-01
发明人： HAYNES, Barton, F. , BONSIGNORI, Mattia , LIAO, Hua-xin , KORBER, Bette, T. , HRABER, Peter, T. , SAUNDERS, Kevin
IPC分类号： C07K14/155 , C07K14/16
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公开(公告)号：EP3423091A2
公开(公告)日：2019-01-09
申请号：EP17760960.9
申请日：2017-03-03
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公开(公告)号：EP3122881A1
公开(公告)日：2017-02-01
申请号：EP15769306.0
申请日：2015-03-25
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/70 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： The invention is directed to mosaic HIV 1 genes designed to induce T-cell responses.
摘要翻译： 本发明涉及设计用于诱导T细胞应答的镶嵌HIV 1基因。
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公开(公告)号：EP3119890A1
公开(公告)日：2017-01-25
申请号：EP15764507.8
申请日：2015-03-19
IPC分类号： C12N15/46 , C07K14/155 , C12N15/85 , A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16134
摘要： In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
摘要翻译： 在某些方面，本发明提供HIV-1免疫原，包括信封（CH505）及其选择，以及使用HIV-1包膜组合的群体免疫的方法。
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公开(公告)号：EP3197488A2
公开(公告)日：2017-08-02
申请号：EP15843595.8
申请日：2015-09-25
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K31/4706 , A61K39/12 , A61K39/3955 , A61K47/48276 , A61K47/4833 , A61K47/48338 , A61K47/48815 , A61K2039/505 , A61K2039/545 , A61K2039/6018 , A61K2039/627 , C07K14/70578 , C07K2319/70 , C12N7/00 , C12N2740/16134
摘要： In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
摘要翻译： 在某些方面，本发明提供了适合用作免疫原的HIV-1包膜的选择，以及使用这些免疫原诱导中和抗体的方法。 在某些实施方案中，免疫原被设计为三聚。 在其他实施方案中，免疫原包含免疫调节组分。
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公开(公告)号：EP2986628A1
公开(公告)日：2016-02-24
申请号：EP14785257.8
申请日：2014-04-15
申请人： Duke University , The Government of The US, as Represented by The Secretary of the Army, on behalf of Walter Reed Army Institute of Research , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , Los Alamos National Security, LLC
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus-1 (HIV - 1) particular, to a polyvalent vaccine for HIV -1 and to methods of making and using same.
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10.发明公开
公开(公告)号：EP2566884A2
公开(公告)日：2013-03-13
申请号：EP11777718.5
申请日：2011-05-09
CPC分类号： A61K39/42 , A61K39/12 , A61K39/21 , A61K2039/53 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to HIV-1 and, in particular, to immunogens that elicit broadly neutralizing antibodies against HIV-1 subtype C envelope glycoproteins, and compositions comprising same. The invention further relates to methods of inducing the production of such antibodies in a subject.
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