专利检索 ap:("Dyax Corp." OR "Biogen Hemophilia Inc.") AND inv:"MURUGANANDAM, Arumugam" 第 1 页

1.

发明公开
METHOD OF PRODUCING ANTIBODIES AGAINST FCRN AND USE THEREOF 审中-公开

公开(公告)号：EP3348573A1

公开(公告)日：2018-07-18

申请号：EP17195757.4

申请日：2009-04-24

申请人： Dyax Corp. , Biogen Hemophilia Inc.

发明人： TENHOOR, Christopher , MURUGANANDAM, Arumugam , LADNER, Robert, Charles , WOOD, Clive , BITONTI, Alan, J. , STATTEL, James , MCDONNELL, Kevin , LIU, Liming , DUMONT, Jennifer , SATO, Aaron

IPC分类号： C07K16/28 , A61P37/00

摘要： This disclosure provides, inter alia , proteins that bind to FcRn, e.g ., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

2.

发明授权
ANTIBODIES AGAINST FCRN AND USE THEREOF 有权

公开(公告)号：EP2310415B8

公开(公告)日：2017-12-13

申请号：EP09734929.4

申请日：2009-04-24

申请人： Dyax Corp. , Biogen Hemophilia Inc.

发明人： TENHOOR, Christopher , MURUGANANDAM, Arumugam , LADNER, Robert, Charles , WOOD, Clive , BITONTI, Alan, J. , STATTEL, James , MCDONNELL, Kevin , LIU, Liming , DUMONT, Jennifer , SATO, Aaron

IPC分类号： C07K16/28 , G01N33/68

CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535

3.

发明授权
ANTIBODIES AGAINST FCRN AND USE THEREOF 有权

公开(公告)号：EP2310415B1

公开(公告)日：2017-10-11

申请号：EP09734929.4

申请日：2009-04-24

申请人： Dyax Corporation , Biogen Hemophilia Inc.

发明人： TENHOOR, Christopher , MURUGANANDAM, Arumugam , LADNER, Robert, Charles , WOOD, Clive , BITONTI, Alan, J. , STATTEL, James , MCDONNELL, Kevin , LIU, Liming , DUMONT, Jennifer , SATO, Aaron

IPC分类号： C07K16/28 , G01N33/68

CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535

4.

发明授权
METHOD OF PRODUCING ANTIBODIES AGAINST FCRN AND USE THEREOF 有权

公开(公告)号：EP3348573B1

公开(公告)日：2020-04-22

申请号：EP17195757.4

申请日：2009-04-24

申请人： Dyax Corp. , Bioverativ Therapeutics Inc.

发明人： TENHOOR, Christopher , MURUGANANDAM, Arumugam , LADNER, Robert, Charles , WOOD, Clive , BITONTI, Alan, J. , STATTEL, James , MCDONNELL, Kevin , LIU, Liming , DUMONT, Jennifer , SATO, Aaron

IPC分类号： C07K16/28 , A61P37/00

5.

发明公开
BISPECIFIC BINDING AGENTS TARGETING IGF-1R AND ERBB3 SIGNALLING AND USES THEREOF 审中-公开
标题翻译：对IGF-1R和信令ERBB3 LOOKING BISPEZFISCHE粘合剂和使用

公开(公告)号：EP2488199A1

公开(公告)日：2012-08-22

申请号：EP10775965.6

申请日：2010-10-14

申请人： Merrimack Pharmaceuticals, Inc. , Dyax Corp.

发明人： SCHOEBERL, Birgit , NIELSEN, Ulrik , KUDLA, Arthur, J. , MURUGANANDAM, Arumugam , BUCKLER, David , LUGOVSKOY, Alexey, Alexandrovich , FITZGERALD, Jonathan, Basil , XU, Lihui , KOHLI, Neeraj

IPC分类号： A61K39/395 , A61P35/00 , C07K14/525 , C07K14/765 , C07K16/28 , C07K16/32 , C07K16/46 , C07K19/00

CPC分类号： C07K16/2863 , A61K39/39558 , A61K2039/505 , C07K16/32 , C07K2317/21 , C07K2317/31 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/31 , C07K2319/70

摘要： Disclosed are bispecific binding agents that specifically target both of the IGF-1 and the ErbB intracellular signaling pathways. For example, bispecific binding agents that comprise an anti-IGF-1R antibody and an anti-ErbB3 antibody connected by a linker are described herein. These bispecific agents are capable of antagonizing signal transduction by both of the IGF-1 and the ErbB signaling pathways and are useful in inhibiting the proliferation of tumor cells whose growth involves the signaling activity of both pathways.