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公开(公告)号：EP3348573B1
公开(公告)日：2020-04-22
申请号：EP17195757.4
申请日：2009-04-24
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公开(公告)号：EP3326643A1
公开(公告)日：2018-05-30
申请号：EP17194648.6
申请日：2010-12-06
发明人： DUMONT, Jennifer, A. , LOW, Susan , BITONTI, Alan, J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg M. , NUGENT, Karen , LI, Lian , PETERS, Robert
IPC分类号： A61K38/37 , A61K47/68 , A61K47/64 , C07K14/755 , A61P7/04
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30 , Y02A90/26
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：EP3513804A1
公开(公告)日：2019-07-24
申请号：EP18211156.7
申请日：2012-07-06
发明人： DUMONT, Jennifer A. , LOW, Susan , BITONTI, Alan, J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg , NUGENT, Karen , LI, Lian , PETERS, Robert
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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4.发明授权FACTOR VIII-FC CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF 有权因子VIII-FC嵌合和杂合多肽及其使用方法
公开(公告)号：EP2506868B1
公开(公告)日：2017-11-15
申请号：EP10835255.0
申请日：2010-12-06
发明人： DUMONT, Jennifer, A. , LOW, Susan , BITONTI, Alan, J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg , NUGENT, Karen , LI, Lian , PETERS, Robert
IPC分类号： A61K38/37 , C07K14/755 , C07K16/46 , A61P7/04
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
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公开(公告)号：EP2310415B8
公开(公告)日：2017-12-13
申请号：EP09734929.4
申请日：2009-04-24
申请人： Dyax Corp. , Biogen Hemophilia Inc.
发明人： TENHOOR, Christopher , MURUGANANDAM, Arumugam , LADNER, Robert, Charles , WOOD, Clive , BITONTI, Alan, J. , STATTEL, James , MCDONNELL, Kevin , LIU, Liming , DUMONT, Jennifer , SATO, Aaron
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
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公开(公告)号：EP3348573A1
公开(公告)日：2018-07-18
申请号：EP17195757.4
申请日：2009-04-24
申请人： Dyax Corp. , Biogen Hemophilia Inc.
发明人： TENHOOR, Christopher , MURUGANANDAM, Arumugam , LADNER, Robert, Charles , WOOD, Clive , BITONTI, Alan, J. , STATTEL, James , MCDONNELL, Kevin , LIU, Liming , DUMONT, Jennifer , SATO, Aaron
摘要： This disclosure provides, inter alia , proteins that bind to FcRn, e.g ., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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