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1.发明公开MUTANT DELTA-9 ELONGASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 有权突变Δ9延伸酶和它们在多不饱和脂肪酸的生产
公开(公告)号：EP2609201A1
公开(公告)日：2013-07-03
申请号：EP11750066.0
申请日：2011-08-26
发明人： BOSTICK, Michael W. , HE, Hongxian , LI, Yougen , ZHU, Qun
CPC分类号： C12N9/1029 , C12N15/815 , C12P7/6472 , C12Y203/01016
摘要： Mutant delta-9 elongases having the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA] and/or a-linolenic [18:3, ALA] to eicosatrienoic acid [20:3, ETrA] are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant delta-9 elongases, along with a method of making long chain polyunsaturated fatty acids ["PUFAs"] using these mutant delta-9 elongases in oleaginous yeast are also disclosed.
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2.发明公开MUTANT HPGG MOTIF AND HDASH MOTIF DELTA-5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开MUTANT HPGG-动机和HDASH MOTIF DELTA 5-去饱和酶和它们在多不饱和脂肪酸的生产
公开(公告)号：EP2609202A1
公开(公告)日：2013-07-03
申请号：EP11751773.0
申请日：2011-08-26
发明人： BOSTICK, Michael, W. , DAUBERT, Melissa, D. , HE, Hongxian , HONG, Seung-Pyo , POLLAK, Dana, M., Walters , SHARPE, Pamela, L. , WANG, Yehong, Jamie , XUE, Zhixiong , YADAV, Narendra, S. , ZHANG, Hongxiang , ZHU, Qun
CPC分类号： C12N9/001 , C12P7/6472 , C12Y103/01035
摘要： Mutant delta-5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3] to eicosapentaenoic acid [EPA; 20:5 omega-3] and possessing at least one mutation within the HPGG (SEQ ID NO:7) motif of the cytochome b5-like domain and at least one mutation within the HDASH (SEQ ID NO:8) motif are disclosed. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases, along with a method of making long chain polyunsaturated fatty acids ["PUFAs"], are also disclosed.
摘要翻译： 突变型Δ-5去饱和酶，具有将二高-γ-亚麻酸[DGLA的能力; 20：3ω-6]成花生四烯酸[ARA; 20：4ω-6]和/或二十碳四烯酸[ETA; 20：4ω-3]至二十碳五烯酸[EPA; 20：5ω-3]和波塞唱HPGG（SEQ ID NO：7）内的至少一个突变的细胞色素B5样结构域的基序和HDASH内的至少一个突变（SEQ ID NO：8）基序盘游离缺失。 分离的核酸片段和重组构建体，其包含编码Δ-5去饱和酶检查片段，与制备长链多不饱和脂肪酸[“PUFA的”]的方法一起是游离缺失盘。
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3.发明公开
公开(公告)号：EP2609203A1
公开(公告)日：2013-07-03
申请号：EP11752426.4
申请日：2011-08-26
发明人： HONG, Seung-Pyo , SHARPE, Pamela, L. , XUE, Zhixiong , YADAV, Narendra, S. , ZHANG, Hongxiang , ZHU, Qun
CPC分类号： C12N9/1029 , C12N9/0071 , C12N15/815 , C12P7/6472
摘要： Engineered strains of the oleaginous yeast Yarrowia lipolytica are disclosed herein that are capable of producing microbial oil comprising greater than 25 weight percent of eicosapentaenoic acid [“EPA”], an omega-3 polyunsaturated fatty acid, measured as a weight percent of dry cell weight.
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公开(公告)号：EP1104467A2
公开(公告)日：2001-06-06
申请号：EP99934163.9
申请日：1999-07-21
IPC分类号： C12N15/29 , C07K14/415 , C12N5/10 , C12Q1/68
CPC分类号： C12N15/8242 , C07K14/415 , C12N15/8261 , Y02A40/146
摘要： This invention relates to an isolated nucleic acid fragment encoding a PC4 transcription coactivator. The invention also relates to the construction of a chimeric gene encoding all or a portion of the PC4 transcription coactivator, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the PC4 transcription coactivator in a transformed host cell.
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公开(公告)号：EP1226240A2
公开(公告)日：2002-07-31
申请号：EP00988367.9
申请日：2000-12-22
发明人： ZHU, Qun , FAMODU, Omolayo, O.
IPC分类号： C12N15/00
CPC分类号： C07K14/415 , C12N15/8216 , C12N15/8279
摘要： This invention relates to an isolated nucleic acid fragment encoding an SPF1-related transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the SPF1-related transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the SPF1-related transcription factor in a transformed host cell.
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