ACYLATED CYCLODEXTRIN GUEST INCLUSION COMPLEXES
    1.
    发明授权
    ACYLATED CYCLODEXTRIN GUEST INCLUSION COMPLEXES 有权
    酰化环糊精GUEST包合物

    公开(公告)号:EP1280559B1

    公开(公告)日:2006-03-08

    申请号:EP01928906.5

    申请日:2001-04-26

    IPC分类号: A61K47/48

    摘要: The present invention is directed to a method of making an inclusion complex comprising an acylated cyclodextrin host molecule and a guest molecule, wherein the method comprises the steps of: (a) contacting the acylated cyclodextrin host molecule and the guest molecule to form an inclusion complex; and (b) precipitating the inclusion complex in an aqueous medium. The present invention is further directed to an inclusion complex comprising an acylated cyclodextrin host molecule and a guest molecule, wherein the guest molecule comprises form about 2 % (wt.) to about 15 % (wt.) of the inclusion complex. Moreover, the present invention relates to a composition comprising a polymer and an inclusion complex, wherein the inclusion complex comprises an acylated cyclodextrin host molecule and a guest molecule and medical devices and solid pharmaceutical compositions comprised thereof.

    ACYLATED CYCLODEXTRIN GUEST INCLUSION COMPLEXES
    5.
    发明公开
    ACYLATED CYCLODEXTRIN GUEST INCLUSION COMPLEXES 有权
    酰化环糊精GUEST包合物

    公开(公告)号:EP1280559A2

    公开(公告)日:2003-02-05

    申请号:EP01928906.5

    申请日:2001-04-26

    IPC分类号: A61K47/48

    摘要: The present invention is directed to a method of making an inclusion complex comprising an acylated cyclodextrin host molecule and a guest molecule, wherein the method comprises the steps of: (a) contacting the acylated cyclodextrin host molecule and the guest molecule to form an inclusion complex; and (b) precipitating the inclusion complex in an aqueous medium. The present invention is further directed to an inclusion complex comprising an acylated cyclodextrin host molecule and a guest molecule, wherein the guest molecule comprises form about 2 % (wt.) to about 15 % (wt.) of the inclusion complex. Moreover, the present invention relates to a composition comprising a polymer and an inclusion complex, wherein the inclusion complex comprises an acylated cyclodextrin host molecule and a guest molecule and medical devices and solid pharmaceutical compositions comprised thereof.