公开(公告)号：EP3381506A1

公开(公告)日：2018-10-03

申请号：EP17163191.4

申请日：2017-03-28

申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

发明人： Wurth, Sophie ,  Courtine, Grégoire ,  Micera, Silvestro

IPC分类号： A61N1/05 ,  A61N1/04 ,  A61B5/00 ,  A61B5/11 ,  A61B5/0488 ,  A61N1/36

CPC分类号： A61N1/36139 ,  A61B5/04888 ,  A61B5/112 ,  A61B5/1124 ,  A61B5/6829 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0551 ,  A61N1/36003 ,  A61N1/36062 ,  A61N1/36132

摘要： The present invention relates to a neuromodulation and/or neurostimulation system (10) comprising at least the following components:
- at least one sensing unit (12),
- at least control unit (14),
- at least one stimulation unit (16),
- at least one Central Nervous System (CNS) stimulation module (18),
- at least one Peripheral Nervous System (PNS) stimulation module (20),
wherein at least one of the components of the neuromodulation and/or neurostimulation system (10) is implantable.

公开(公告)号：EP2868343A1

公开(公告)日：2015-05-06

申请号：EP13191003.6

申请日：2013-10-31

申请人： Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO

发明人： Courtine, Grégoire ,  Wenger, Nikolaus ,  Martin Moraud, Eduardo ,  Micera, Silvestro

IPC分类号： A61N1/36 ,  A61B5/00

CPC分类号： A61N1/36067 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/112 ,  A61B5/1121 ,  A61B5/1127 ,  A61B5/4836 ,  A61B5/7282 ,  A61B2562/0219 ,  A61B2562/0247 ,  A61N1/0551 ,  A61N1/36003 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36139

摘要： The present invention provides a closed-loop system for real-time control of epidural electrical stimulation comprising: a) means for applying to a subject neuromodulation with adjustable stimulation parameters, said means a) being operatively connected with b) a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals providing features of motion of said subject, said system b) being operatively connected with c) a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means a) and providing said means a) with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.

摘要翻译： 本发明提供了用于硬膜外电刺激包括实时控制的闭环系统：1）用于施加到具有可调刺激参数的受试者的神经调节装置，所述装置A）可操作地与相连接）实时监视组件 包括传感器连续地从所述受试者获取的反馈信号，所述提供所述受试者，所述系统b）的运动的特征信号可操作以c连接）的信号处理设备接收所述反馈信号和操作实时自动控制算法，所述信号处理 装置可操作地与所述装置A）和提供所述指）以及新的刺激参数，以最小的延迟连接。 在本发明的系统改善与神经运动障碍的受试者行走一致性。 使用实时自动控制算法，包括一前馈成分使用单输入单输出模型（SISO），或一个多输入单输出（MISO）模型。