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1.发明授权
公开(公告)号：EP0115850B1
公开(公告)日：1989-02-08
申请号：EP84101001.0
申请日：1984-02-01
申请人： Eisai Co., Ltd.
发明人： Tachibana, Shinro , Ohya, Shizuko , Arakawa, Yoshihiro , Nakazawa, Takahiro , Kaneko, Takeru , Ikeda, Masuhiro , Yamatsu, Kiyomi
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55
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2.发明公开
公开(公告)号：EP0181001A2
公开(公告)日：1986-05-14
申请号：EP85114226.5
申请日：1985-11-08
申请人： Eisai Co., Ltd.
发明人： Yoshino, Hiroshi , Tsuchiya, Yutaka , Kaneko, Takeru , Nakazawa, Takahiro , Ikeda, Masuhiro , Araki, Shin , Yamatsu, Kiyomi , Tachibana, Shinro , Arakawa, Yoshihiro
IPC分类号： C07K14/665 , A61K38/33
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55 , Y10S514/809 , Y10S930/26
摘要： Polypeptide, a process for preparing the same, a pharmaceutical composition containing said polypeptide as well as the use thereof
There is disclosed a novel polypeptide, a process for preparing the same, a pharmaceutical composition containing the same as well as the use thereof. The novel polypeptide which is useful as an analgesic corresponds to the formula given below:
wherein the meaning of R 1 and R 2 , A, B, C, D, E, and F is the same as defined in the claims.摘要翻译： 有游离缺失盘一个新的多肽，其制备，含有其的药物组合物以及它们的使用方法。 该新的多肽的所有这是有用的作为镇痛对应于下式：...
... worin R的含义<1>和R <2>中，A，B，C，D，E，和F是相同的 在权利要求书中所定义。 -
公开(公告)号：EP0318029B1
公开(公告)日：1996-02-07
申请号：EP88119675.2
申请日：1988-11-25
申请人： Eisai Co., Ltd.
发明人： Sugimoto, Hachiro , Nakamura, Takaharu , Karibe, Norio , Saito, Isao , Higurashi, Kunizo , Yonaga, Masahiro , Kaneko, Takeru , Nakazawa, Takahiro , Ueno, Masataka , Yamatsu, Kiyomi , Ueno, Kohshi , Ikeda, Masuhiro
IPC分类号： C07D211/14 , C07D211/32 , C07D211/40 , C07D401/12 , C07D211/18 , C07D211/58 , C07D223/04 , A61K31/445 , A61K31/55
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
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4.发明公开
公开(公告)号：EP0115850A3
公开(公告)日：1987-02-04
申请号：EP84101001
申请日：1984-02-01
申请人： Eisai Co., Ltd.
发明人： Tachibana, Shinro , Ohya, Shizuko , Arakawa, Yoshihiro , Nakazawa, Takahiro , Kaneko, Takeru , Ikeda, Masuhiro , Yamatsu, Kiyomi
IPC分类号： C07C103/52 , A61K37/02
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55
摘要： A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Ile-Arg-Pro-Lys-D-Leu-Lys-Trp-NH 2 (in which D · lie and D b.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method and pharmaceutical compositions containing said peptide are also disclosed.
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5.发明公开
公开(公告)号：EP0115850A2
公开(公告)日：1984-08-15
申请号：EP84101001.0
申请日：1984-02-01
申请人： Eisai Co., Ltd.
发明人： Tachibana, Shinro , Ohya, Shizuko , Arakawa, Yoshihiro , Nakazawa, Takahiro , Kaneko, Takeru , Ikeda, Masuhiro , Yamatsu, Kiyomi
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55
摘要： A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Ile-Arg-Pro-Lys-D-Leu-Lys-Trp-NH 2 (in which D · lie and D b.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method and pharmaceutical compositions containing said peptide are also disclosed.
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公开(公告)号：EP0318029A3
公开(公告)日：1990-09-26
申请号：EP88119675.2
申请日：1988-11-25
申请人： Eisai Co., Ltd.
发明人： Sugimoto, Hachiro , Nakamura, Takaharu , Karibe, Norio , Saito, Isao , Higurashi, Kunizo , Yonaga, Masahiro , Kaneko, Takeru , Nakazawa, Takahiro , Ueno, Masataka , Yamatsu, Kiyomi , Ueno, Kohshi , Ikeda, Masuhiro
IPC分类号： C07D211/14 , C07D211/32 , C07D211/40 , C07D401/12 , C07D211/18 , C07D211/58 , C07D223/04 , A61K31/445 , A61K31/55
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
摘要： A cyclic amine is defined by the formula:
in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or -YZ, Y being -0-, -CO- or -NH-, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful for the making of a medicament to treat a mental symptome associated with a cerebrovascular disease and respective pharmaceutical compositions are disclosed.-
7.发明公开
公开(公告)号：EP0318029A2
公开(公告)日：1989-05-31
申请号：EP88119675.2
申请日：1988-11-25
申请人： Eisai Co., Ltd.
发明人： Sugimoto, Hachiro , Nakamura, Takaharu , Karibe, Norio , Saito, Isao , Higurashi, Kunizo , Yonaga, Masahiro , Kaneko, Takeru , Nakazawa, Takahiro , Ueno, Masataka , Yamatsu, Kiyomi , Ueno, Kohshi , Ikeda, Masuhiro
IPC分类号： C07D211/14 , C07D211/32 , C07D211/40 , C07D401/12 , C07D211/18 , C07D211/58 , C07D223/04 , A61K31/445 , A61K31/55
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
摘要： A cyclic amine is defined by the formula:
in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or -YZ, Y being -0-, -CO- or -NH-, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful for the making of a medicament to treat a mental symptome associated with a cerebrovascular disease and respective pharmaceutical compositions are disclosed.摘要翻译： 环胺由下式定义：其中A为萘基，苯基，喹啉基或烷基，X为含羰基的基团，n为2或3，B为烷基，卤素，苯基或-YZ，Y为 -O-，-CO-或-NH-，Z为苯基，萘基，吡啶基，烷基或环烷基。 制备用于治疗与脑血管疾病相关的精神症状的药物是有用的，并且公开了各自的药物组合物。
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8.发明公开
公开(公告)号：EP0181001A3
公开(公告)日：1989-04-19
申请号：EP85114226.5
申请日：1985-11-08
申请人： Eisai Co., Ltd.
发明人： Yoshino, Hiroshi , Tsuchiya, Yutaka , Kaneko, Takeru , Nakazawa, Takahiro , Ikeda, Masuhiro , Araki, Shin , Yamatsu, Kiyomi , Tachibana, Shinro , Arakawa, Yoshihiro
IPC分类号： C07K14/665 , A61K38/33
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55 , Y10S514/809 , Y10S930/26
摘要： Polypeptide, a process for preparing the same, a pharmaceutical composition containing said polypeptide as well as the use thereof There is disclosed a novel polypeptide, a process for preparing the same, a pharmaceutical composition containing the same as well as the use thereof. The novel polypeptide which is useful as an analgesic corresponds to the formula given below: wherein the meaning of R 1 and R 2 , A, B, C, D, E, and F is the same as defined in the claims.
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9.发明公开
公开(公告)号：EP0087810A1
公开(公告)日：1983-09-07
申请号：EP83102019.3
申请日：1983-03-02
申请人： Eisai Co., Ltd.
IPC分类号： A61K31/52
CPC分类号： C07D473/10 , C07D473/08
摘要： Pharmaceutial compositions with antiphlogistic/anti- pyretic/analgesic activities containing as active ingredient theobromine and theophylline derivatives represented by the general formula:
wherein one of A and B is -CH 3 and the other of A and B is
wherein R is a hydrogen atom or a lower alkyl group, Z is selected from the group consisting of (1) a group of the formula
wherein X 1 and X 2 are the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom; (2) a pyridyl group; and (3) a group of the formula;
wherein Y 1 and Y 2 are the same or different and Y 1 and Y 2 are selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group and a halogen atom, X is a nitrogen atom or a carbon atom, m is 2 or 3, and n is an integer of from 2 to 10, with the provisos that (i) when A is -CH 3 , m is 2, and (ii) when A is
Z is not pyridyl and X is nitrogen.摘要翻译： Pharmaceutial组合物与消炎含有由通式作为活性成分的可可碱和茶碱衍生物/解热/镇痛活性：...
... worin A和B中的一个为-CH 3和另一个A和B是... ... worin R是氢原子或低级烷基，Z是选自（1）下式基团中的被选择... ... worin X1和X2相同或不同，并且各自darstellt一个氢原子，一个 低级烷基，低级烷氧基，三氟甲基或卤原子; （2）吡啶基; 和（3）下式基团的; ... ... -
公开(公告)号：EP0614913A3
公开(公告)日：1997-06-04
申请号：EP94107769.5
申请日：1985-11-08
申请人： EISAI Co., Ltd.
发明人： Yoshino, Hiroshi , Tsuchiya, Yutaka , Kaneko, Takeru , Nakazawa, Takahiro , Ikeda, Masuhiro , Araki, Shin , Yamatsu, Kiyomi , Tachibana, Shinro , Arakawa, Yoshihiro
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55 , Y10S514/809 , Y10S930/26
摘要： There is disclosed a novel polypeptide, a process for preparing the same, a pharmaceutical composition containing the same as well as the use thereof. The novel polypeptide which is useful as an analgesic corresponds to the formula given below:
wherein the meaning of R 1 and R 2 , A, B, C, D, E, and F is the same as defined in the claims.
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