公开(公告)号：EP1001767A1

公开(公告)日：2000-05-24

申请号：EP98925132.7

申请日：1998-06-01

申请人： ELI LILLY AND COMPANY

发明人： DUNLAP, Steven, Eugene ,  JUNGHEIM, Louis, Nickolaus ,  TEBBE, Mark, Joseph ,  VOY, Gilbert, Thomas ,  WERNER, John, Arnold

IPC分类号： A61K31/415 ,  C07D235/30

CPC分类号： C07D235/30

摘要： The present application provides a series of benzimidazole compounds of formula (I), which inhibit the growth of picornaviruses, such as rhinoviruses (bovine and human), enteroviruses such as polioviruses, coxsackieviruses of the A and B groups, or echo virus, cardioviruses such as encephalomyocarditis (EMC), apthoviruses such as foot and mouth disease virus, and flaviviruses such as hepatitis C virus and bovine viral diarrhea virus. Such compounds are also useful as intermediates for preparing additional benzimidazole antiviral compounds.

公开(公告)号：EP1054859A1

公开(公告)日：2000-11-29

申请号：EP99903432.5

申请日：1999-01-27

申请人： ELI LILLY AND COMPANY

发明人： BARNETT, Charles, Jackson ,  DUNLAP, Steven, Eugene ,  KOBIERSKI, Michael, Edward ,  WERNER, John, Arnold

IPC分类号： C07C255/00 ,  C07D207/02 ,  C07D211/04 ,  C07D213/02 ,  C07D231/02 ,  C07D231/04 ,  C07D231/06 ,  C07D231/10 ,  C07D233/02 ,  C07D233/04 ,  C07D233/54

CPC分类号： C07D471/04 ,  C07D333/38 ,  Y02P20/55

摘要： The present invention concerns intermediates, and processes directed to and from those intermediates, to a series of pyrimidine derivatives of formula (V), which are intermediates to useful antifolate compounds or are themselves useful antifolate compounds.