公开(公告)号：EP1670768A1

公开(公告)日：2006-06-21

申请号：EP04793889.9

申请日：2004-10-07

申请人： ELI LILLY AND COMPANY

发明人： CAO, Guoqing ,  ESCRIBANO, Ana Maria, Lilly, S. A. ,  FERNANDEZ, Maria Carmen, Lilly, S. A. ,  FIELDS, Todd ,  GERNERT, Douglas, Linn ,  CIOFFI, Christopher, Lawrence ,  HERR, Robert, Jason ,  MANTLO, Nathan, Bryan ,  MARTIN DE LA NAVA, Eva Maria, Lilly, S. A. ,  MATEO HERRANZ, Ana Isabel, Lilly, S. A. ,  MAYHUGH, Daniel, Ray ,  WANG, Xiaodong

IPC分类号： C07D223/16 ,  A61K31/55 ,  A61P3/06 ,  A61P9/10 ,  C07D403/04 ,  C07D403/12 ,  C07D223/14 ,  C07D223/32 ,  C07D225/06 ,  C07D405/12 ,  C07D405/06 ,  C07D413/04 ,  C07D491/04

CPC分类号： C07D223/16 ,  C07D223/14 ,  C07D223/32 ,  C07D225/06 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/04 ,  C07D491/04

摘要： Compounds of formula I wherein n, m, p, q, Y, R1 R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating artherosclerosis and its sequelae.

公开(公告)号：EP1373240A2

公开(公告)日：2004-01-02

申请号：EP02728502.2

申请日：2002-03-14

申请人： ELI LILLY AND COMPANY ,  LIGAND PHARMACEUTICALS INCORPORATED

发明人： GARDINIER, Kevin, Matthew ,  GERNERT, Douglas, Linn ,  GRESE, Timothy, Alan ,  NEEL, David, Andrew ,  MAPES, Christopher, M. ,  MICHELLYS, Pierre-Yves ,  BOEHM, Marcus, F.

IPC分类号： C07D307/80

CPC分类号： C07D261/20 ,  C07D209/12 ,  C07D215/14 ,  C07D217/16 ,  C07D231/56 ,  C07D307/80 ,  C07D307/85 ,  C07D333/56 ,  C07D333/60 ,  C07D333/70 ,  C07D471/04 ,  C07D495/04

摘要： The present invention is directed to compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof: (I). The invention is also directed to pharmaceutical compositions, methods of use and methods of making compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof.

公开(公告)号：EP1373240B1

公开(公告)日：2005-06-15

申请号：EP02728502.2

申请日：2002-03-14

申请人： ELI LILLY AND COMPANY ,  LIGAND PHARMACEUTICALS INCORPORATED

发明人： GARDINIER, Kevin, Matthew ,  GERNERT, Douglas, Linn ,  GRESE, Timothy, Alan ,  NEEL, David, Andrew ,  MAPES, Christopher, M. ,  MICHELLYS, Pierre-Yves ,  BOEHM, Marcus, F.

IPC分类号： C07D307/80

CPC分类号： C07D261/20 ,  C07D209/12 ,  C07D215/14 ,  C07D217/16 ,  C07D231/56 ,  C07D307/80 ,  C07D307/85 ,  C07D333/56 ,  C07D333/60 ,  C07D333/70 ,  C07D471/04 ,  C07D495/04

摘要： The present invention is directed to compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof: (I). The invention is also directed to pharmaceutical compositions, methods of use and methods of making compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof.

公开(公告)号：EP1670768B1

公开(公告)日：2009-09-09

申请号：EP04793889.9

申请日：2004-10-07

申请人： ELI LILLY AND COMPANY

发明人： CAO, Guoqing ,  ESCRIBANO, Ana Maria, Lilly, S. A. ,  FERNANDEZ, Maria Carmen, Lilly, S. A. ,  FIELDS, Todd ,  GERNERT, Douglas, Linn ,  CIOFFI, Christopher, Lawrence ,  HERR, Robert, Jason ,  MANTLO, Nathan, Bryan ,  MARTIN DE LA NAVA, Eva Maria, Lilly, S. A. ,  MATEO HERRANZ, Ana Isabel, Lilly, S. A. ,  MAYHUGH, Daniel, Ray ,  WANG, Xiaodong

IPC分类号： C07D223/16 ,  A61K31/55 ,  A61P3/06 ,  A61P9/10 ,  C07D403/04 ,  C07D403/12 ,  C07D223/14 ,  C07D223/32 ,  C07D225/06 ,  C07D405/12 ,  C07D405/06 ,  C07D413/04 ,  C07D491/04

CPC分类号： C07D223/16 ,  C07D223/14 ,  C07D223/32 ,  C07D225/06 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/04 ,  C07D491/04

摘要： Compounds of formula I wherein n, m, p, q, Y, R1 R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating artherosclerosis and its sequelae.

公开(公告)号：EP1597254A1

公开(公告)日：2005-11-23

申请号：EP04703558.9

申请日：2004-01-20

申请人： ELI LILLY AND COMPANY

发明人： BELL, Michael, Gregory ,  GAVARDINAS, Konstantinos ,  GERNERT, Douglas, Linn ,  GRESE, Timothy, Alan ,  JADHAV, Prabhakar, Kondaji ,  LANDER, Peter, Ambrose ,  STEINBERG, Mitchell, Irvin

IPC分类号： C07D409/06 ,  C07D209/10 ,  C07D407/06 ,  C07D209/08 ,  A61K31/404

CPC分类号： C07D401/06 ,  C07D209/08 ,  C07D209/10 ,  C07D333/56 ,  C07D333/68 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D491/04 ,  C07F5/003 ,  C07F5/069 ,  C07F7/0836

摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.