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1.发明公开
公开(公告)号：EP1224189A2
公开(公告)日：2002-07-24
申请号：EP00968314.5
申请日：2000-09-22
发明人： BONJOUKLIAN, Rosanne , JOHNSON, Douglas, Webb , LANDER, Peter, Ambrose , LOHMAN, Mark, Christopher , PATEL, Vinod, Francis , VEPACHEDU, Sreenivasarao , XIE, Yongping
IPC分类号： C07D498/04 , C07D471/04 , A61K31/4741 , A61K31/4745 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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2.发明授权
公开(公告)号：EP1224189B1
公开(公告)日：2006-01-25
申请号：EP00968314.5
申请日：2000-09-22
发明人： BONJOUKLIAN, Rosanne , JOHNSON, Douglas, Webb , LANDER, Peter, Ambrose , LOHMAN, Mark, Christopher , PATEL, Vinod, Francis , VEPACHEDU, Sreenivasarao , XIE, Yongping
IPC分类号： C07D498/04 , C07D471/04 , A61K31/4741 , A61K31/4745 , A61P35/00 , C07D261/00 , C07D221/00 , C07D231/00 , C07D263/00
CPC分类号： C07D471/04
摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1250340B1
公开(公告)日：2004-11-17
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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公开(公告)号：EP2029547B1
公开(公告)日：2010-04-28
申请号：EP07797648.8
申请日：2007-05-22
发明人： BELL, Michael, Gregory , DOTI, Robert, Anthony , GENIN, Michael, James , LANDER, Peter, Ambrose , MA, Tianwei , MANNINEN, Peter, Rudolph , OCHOADA, Jason, Matthew , QU, Fucheng , STELZER, Lindsay, Scott , STITES, Ryan, Edward , WARSHAWSKY, Alan, M.
IPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D417/12 , A61P3/06
CPC分类号： C07D231/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
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公开(公告)号：EP2029547A1
公开(公告)日：2009-03-04
申请号：EP07797648.8
申请日：2007-05-22
发明人： BELL, Michael, Gregory , DOTI, Robert, Anthony , GENIN, Michael, James , LANDER, Peter, Ambrose , MA, Tianwei , MANNINEN, Peter, Rudolph , OCHOADA, Jason, Matthew , QU, Fucheng , STELZER, Lindsay, Scott , STITES, Ryan, Edward , WARSHAWSKY, Alan, M.
IPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D417/12 , A61P3/06
CPC分类号： C07D231/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
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公开(公告)号：EP1597254A1
公开(公告)日：2005-11-23
申请号：EP04703558.9
申请日：2004-01-20
发明人： BELL, Michael, Gregory , GAVARDINAS, Konstantinos , GERNERT, Douglas, Linn , GRESE, Timothy, Alan , JADHAV, Prabhakar, Kondaji , LANDER, Peter, Ambrose , STEINBERG, Mitchell, Irvin
IPC分类号： C07D409/06 , C07D209/10 , C07D407/06 , C07D209/08 , A61K31/404
CPC分类号： C07D401/06 , C07D209/08 , C07D209/10 , C07D333/56 , C07D333/68 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D491/04 , C07F5/003 , C07F5/069 , C07F7/0836
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
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公开(公告)号：EP2029558B1
公开(公告)日：2010-03-10
申请号：EP07811915.3
申请日：2007-05-22
发明人： BELL, Michael, Gregory , DOTI, Robert, Anthony , DOWLING, Matthew, Scott , GENIN, Michael, James , LANDER, Peter, Ambrose , MA, Tianwei , MANTLO, Nathan, Bryan , OCHOADA, Jason, Matthew , STELZER, Lindsay, Scott , STITES, Ryan, Edward , WARSHAWSKY, Alan, M
IPC分类号： C07D249/12 , C07D401/12 , C07D403/12 , C07D409/12 , A61K31/4192 , A61P3/06
CPC分类号： C07D249/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 其中变量如本文所定义的式（I）化合物及其药物组合物和使用方法公开可用于治疗血脂异常和相关疾病。
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公开(公告)号：EP2029558A2
公开(公告)日：2009-03-04
申请号：EP07811915.3
申请日：2007-05-22
发明人： BELL, Michael, Gregory , DOTI, Robert, Anthony , DOWLING, Matthew, Scott , GENIN, Michael, James , LANDER, Peter, Ambrose , MA, Tianwei , MANTLO, Nathan, Bryan , OCHOADA, Jason, Matthew , STELZER, Lindsay, Scott , STITES, Ryan, Edward , WARSHAWSKY, Alan, M
IPC分类号： C07D249/12 , C07D401/12 , C07D403/12 , C07D409/12 , A61K31/4192 , A61P3/06
CPC分类号： C07D249/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
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公开(公告)号：EP1385852B1
公开(公告)日：2005-07-20
申请号：EP02719126.1
申请日：2002-03-27
IPC分类号： C07D498/14 , A61K31/44 , A61P35/00
CPC分类号： C07D498/04
摘要： The present invention relates to a compound of formula (I) which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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10.发明授权COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA 有权VERBINDUNGEN UND VERFAHREN ZUR BEHANDLUNG VONDYSLIPIDÄMIE
公开(公告)号：EP1735320B1
公开(公告)日：2009-06-17
申请号：EP05725968.1
申请日：2005-03-17
发明人： BELL, Michael, Gregory , CAO, Guoqing , ESCRIBANO, Ana Maria, Lilly, S. A. , FERNANDEZ, Maria Carmen, Lilly, S. A. , LANDER, Peter, Ambrose , MANTLO, Nathan, Bryan , MARTIN DE LA NAVA, Eva Maria, Lilly, S. A. , MATEO HERRANZ, Ana Isabel, Lilly, S. A. , MAYHUGH, Daniel, Ray , WANG, Xiaodong
IPC分类号： C07D495/04 , C07D471/04 , A61K31/44 , A61P3/04 , A61P9/00 , A61K31/47 , A61K31/435
CPC分类号： C07D495/04 , C07D471/04 , C07D487/04
摘要： The present invention discloses compounds of formula (I) wherein A, n, q, K, W, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and its sequelae.
摘要翻译： 本发明公开了式（I）的化合物，其中A，n，q，K，W，X，Y; Z，R1，R2，R3，R4，R5和R6如本文所定义，其药物组合物和使用方法被公开用于治疗血脂异常及其后遗症。
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