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公开(公告)号：EP0923543A1
公开(公告)日：1999-06-23
申请号：EP97934996.0
申请日：1997-07-23
发明人： CASTLE, Neil, Alexander , HOLLINSHEAD, Sean, Patrick , HUGHES, Philip, Floyd , MENDOZA, Jose, Serafin , WILSON, Joseph, Wendell , AMATO, George , BEAUDOIN, Serge , GROSS, Michael , McNAUGHTON-SMITH, Grant
CPC分类号： C07C311/20 , C07C2602/08
摘要： Compounds of general formula (I) wherein R1 is H, alkyl or is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R2 is selected from the group consisting of alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R3 is hydrogen or methyl; R4 is hydrogen or methyl; X1 is C=O, C=S, or SO¿2; X?2 is C=O or SO¿2; Y?1 is O, (CH¿2?)p, CH2O, HC=CH or NH; wherein p is 0, 1 or 2; Y?2¿ is O, (CH¿2?)q, HC=CH or NH; wherein q is 0 or 1; Z is H, OR?5 or NR6R7¿; wherein R5 is H, (CH¿2)m-R?8; or C(O)-(CH¿2)m-R?8; m = 1 to 5; R?8 is N(R9)¿2, N(R9)3L or CO2R9; wherein each R9 is independently selected from H or alkyl; and L is a counter ion; R6 is H or alkyl; R7 is H, alkyl or CO¿2R?10; wherein R10 is alkyl; or pharmaceutically acceptable salts or prodrugs thereof are useful as potassium channel inhibitors and useful for the treatment of cardiac arrhythmias and cell proliferative disorders.
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公开(公告)号：EP0758312B1
公开(公告)日：1999-12-22
申请号：EP95913699.5
申请日：1995-03-15
IPC分类号： C07C69/76 , C07C233/00 , C07C49/76 , A01N37/12 , A01N37/18 , C07C69/94 , C07C235/54
CPC分类号： C07D471/08 , C07C69/94 , C07C235/54 , C07C2602/08 , C07C2602/42 , C07C2603/68 , C07D451/12
摘要： Compounds having formula (I) are useful as inhibitors of protein kinase C. Also disclosed are pharmaceutical compositions including such compounds.
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公开(公告)号：EP1082315A1
公开(公告)日：2001-03-14
申请号：EP99927135.6
申请日：1999-06-03
IPC分类号： C07D277/14 , C07D279/06 , C07D417/04 , A61K31/425 , A61K31/54
CPC分类号： C07D417/04 , A61K31/425 , A61K31/54 , C07D277/14 , C07D279/06
摘要： Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases, conditions and disorders.
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公开(公告)号：EP0923543B1
公开(公告)日：2003-09-24
申请号：EP97934996.6
申请日：1997-07-23
发明人： CASTLE, Neil, Alexander , HOLLINSHEAD, Sean, Patrick , HUGHES, Philip, Floyd , MENDOZA, Jose, Serafin , WILSON, Joseph, Wendell , AMATO, George , BEAUDOIN, Serge , GROSS, Michael , McNAUGHTON-SMITH, Grant
IPC分类号： C07C311/20 , C07D213/81 , C07C335/20 , C07C335/22 , C07D261/18 , C07C311/29 , C07C311/13 , C07C311/07 , C07C311/21 , A61K31/18
CPC分类号： C07C311/20 , C07C2602/08
摘要： Compounds of general formula (I) wherein R is H, alkyl or is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R is selected from the group consisting of alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R is hydrogen or methyl; R is hydrogen or methyl; X is C=O, C=S, or SO2; X is C=O or SO2; Y is O, (CH2)p, CH2O, HC=CH or NH; wherein p is 0, 1 or 2; Y is O, (CH2)q, HC=CH or NH; wherein q is 0 or 1; Z is H, OR or NR R ; wherein R is H, (CH2)m-R ; or C(O)-(CH2)m-R ; m = 1 to 5; R is N(R )2, N(R )3L or CO2R ; wherein each R is independently selected from H or alkyl; and L is a counter ion; R is H or alkyl; R is H, alkyl or CO2R ; wherein R is alkyl; or pharmaceutically acceptable salts or prodrugs thereof are useful as potassium channel inhibitors and useful for the treatment of cardiac arrhythmias and cell proliferative disorders.
摘要翻译： 描述了可用作钾通道抑制剂并且特别可用于治疗心律失常和细胞增殖性疾病的化合物。
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公开(公告)号：EP0758312A1
公开(公告)日：1997-02-19
申请号：EP95913699.0
申请日：1995-03-15
IPC分类号： C07D451 , A61K31 , A61P3 , A61P9 , A61P25 , A61P29 , A61P31 , A61P35 , A61P43 , C07C69 , C07C235 , C07D471
CPC分类号： C07D471/08 , C07C69/94 , C07C235/54 , C07C2602/08 , C07C2602/42 , C07C2603/68 , C07D451/12
摘要： Compounds having formula (I) are useful as inhibitors of protein kinase C. Also disclosed are pharmaceutical compositions including such compounds.
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