公开(公告)号：EP1355945A2

公开(公告)日：2003-10-29

申请号：EP02714718.0

申请日：2002-01-18

申请人： ELI LILLY AND COMPANY

发明人： JENKINS, Nigel ,  WITCHER, Derrick, Ryan ,  WROBLEWSKI, Victor, John

IPC分类号： C07K14/705 ,  A61K38/17

CPC分类号： C07K14/70578 ,  A61K38/00

摘要： The present invention provides FLINT isoforms having an average sialic acid content of 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0 or greater than 4.0 per molecule of FLINT. Also provided are mixtures of said isoforms, and methods for making said isoforms.

公开(公告)号：EP1165780A2

公开(公告)日：2002-01-02

申请号：EP00916263.7

申请日：2000-03-20

申请人： ELI LILLY AND COMPANY

发明人： BECKER, Gerald, Wayne ,  COHEN, Fredric, Jay ,  GONZALEZ-DEWHITT, Patricia, Ann ,  HALE, John, Edward ,  MICANOVIC, Radmila ,  NEWTON, Christy, Michelle ,  NOBLITT, Timothy, Wayne ,  RATHMACHALAM, Radhakrishnan ,  TSCHANG, Sheng-Hung, Rainbow ,  WITCHER, Derrick, Ryan ,  WROBLEWSKI, Victor, John

IPC分类号： C12N15/12 ,  C12N15/62 ,  C07K14/705 ,  C12P21/02 ,  A61K38/17 ,  A61P11/00

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30

摘要： Disclosed are polypeptide analogs of FLINT, polydeoxynucleotides encoding FLINT analogs, and methods of using FLINT analogs and polydeoxynucleotides. The FLINT analogs of the invention include polypeptides having the amino acid sequence of FLINT, modified at one or more positions with amino acid substitutions, and include fragments thereof, as well as Fc fusions comprising FLINT and FLINT analogs.