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1.发明授权PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER 有权吡唑并吡啶衍生物作为TGF BETA抑制剂用于治疗癌症的
公开(公告)号：EP1543001B1
公开(公告)日：2007-08-15
申请号：EP03749105.7
申请日：2003-09-16
发明人： BEIGHT, Douglas, Wade , BONJOUKLIAN, Rosanne , LIAO, Junkai , MCMILLEN, William, Thomas , PARKHURST, Brandon, Lee , SAWYER, Jason, Scott , YINGLING, Jonathan, Michael , YORK, Jeremy, Schulenburg
IPC分类号： C07D471/04 , A61K31/41 , A61P35/00 , A61P17/00
CPC分类号： C07D471/04
摘要： Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
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公开(公告)号：EP1397364B1
公开(公告)日：2007-07-25
申请号：EP02744115.3
申请日：2002-05-13
发明人： SAWYER, Jason, Scott , BEIGHT, Douglas, Wade , CIAPETTI, Paola , DECOLLO, Todd, Vincent , GODFREY, Alexander, Glenn , GOODSON, Theodore, Jr. , HERRON, David, Kent , LI, Hong-Yu , LIAO, Junkai , MCMILLEN, William, Thomas , MILLER, Shawn, Christopher , MORT, Nicolas, Anthony , YINGLING, Jonathan, Michael , SMITH, Edward, C., R.
IPC分类号： C07D487/04 , C07D498/04 , C07D471/04 , A61P7/04 , A61P25/28 , A61P31/00 , A61P43/00 , A61K31/33 , A61K31/41 , A61K31/535
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S.
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公开(公告)号：EP1565471B1
公开(公告)日：2006-10-04
申请号：EP03768531.0
申请日：2003-11-10
IPC分类号： C07D487/04 , A61K31/4162 , A61K31/4709 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4709
摘要： A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound.
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公开(公告)号：EP1565471A1
公开(公告)日：2005-08-24
申请号：EP03768531.0
申请日：2003-11-10
IPC分类号： C07D487/04 , A61K31/4162 , A61K31/4709 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4709
摘要： A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound.
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公开(公告)号：EP1543001A1
公开(公告)日：2005-06-22
申请号：EP03749105.7
申请日：2003-09-16
发明人： BEIGHT, Douglas, Wade , BONJOUKLIAN, Rosanne , LIAO, Junkai , MCMILLEN, William, Thomas , PARKHURST, Brandon, Lee , SAWYER, Jason, Scott , YINGLING, Jonathan, Michael , YORK, Jeremy, Schulenburg
IPC分类号： C07D471/04 , A61K31/41 , A61P35/00 , A61P17/00
CPC分类号： C07D471/04
摘要： Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
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公开(公告)号：EP1397364A1
公开(公告)日：2004-03-17
申请号：EP02744115.3
申请日：2002-05-13
发明人： SAWYER, Jason, Scott , BEIGHT, Douglas, Wade , CIAPETTI, Paola , DECOLLO, Todd, Vincent , GODFREY, Alexander, Glenn , GOODSON, Theodore, Jr. , HERRON, David, Kent , LI, Hong-Yu , LIAO, Junkai , MCMILLEN, William, Thomas , MILLER, Shawn, Christopher , MORT, Nicolas, Anthony , YINGLING, Jonathan, Michael , SMITH, Edward, C., R.
IPC分类号： C07D487/04 , C07D498/04 , C07D471/04 , A61P7/04 , A61P25/28 , A61P31/00 , A61P43/00 , A61K31/33 , A61K31/41 , A61K31/535
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S.
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