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1.发明授权PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER 有权吡唑并吡啶衍生物作为TGF BETA抑制剂用于治疗癌症的
公开(公告)号：EP1543001B1
公开(公告)日：2007-08-15
申请号：EP03749105.7
申请日：2003-09-16
Applicant: ELI LILLY AND COMPANY
Inventor： BEIGHT, Douglas, Wade , BONJOUKLIAN, Rosanne , LIAO, Junkai , MCMILLEN, William, Thomas , PARKHURST, Brandon, Lee , SAWYER, Jason, Scott , YINGLING, Jonathan, Michael , YORK, Jeremy, Schulenburg
IPC: C07D471/04 , A61K31/41 , A61P35/00 , A61P17/00
CPC classification number: C07D471/04
Abstract: Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
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公开(公告)号：EP1554272B1
公开(公告)日：2006-10-25
申请号：EP03784749.8
申请日：2003-07-31
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , DE DIEGO GOMEZ, Jose, Eugenio Lilly, S. A. , DE DIOS, Alfonso Lilly, S. A. , HAMDOUCHI, Chafiq, Hamdouchi , LI, Tiechao , LOPEZ DE URALDE GARMENDIA, Beatriz Lilly, S. A. , VIETH, Michal , YORK, Jeremy, Schulenburg , DALLY, Robert, Dean , DEL PRADO CATALINA, Miriam, Filadelfa Lilly, S. A. , JARAMILLO, Carlos Lilly, S. A. , MARTIN CABREJAS, Luisa, Maria Lilly, S. A. , MONTERO SALGADO, Carlos Lilly, S. A. , PLEITE, Sheila Lilly, S. A. , SANCHEZ-MARTINEZ, Concepcion Lilly, S. A. , SHEPHERD, Timothy, Alan , WIKEL, James, Howard
IPC: C07D409/14 , C07D403/04 , C07D401/14 , C07D405/14 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D409/04 , C07D417/04 , A61K31/41 , A61P35/04
CPC classification number: C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D513/04
Abstract: The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis.
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3.发明公开
公开(公告)号：EP1224189A2
公开(公告)日：2002-07-24
申请号：EP00968314.5
申请日：2000-09-22
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , JOHNSON, Douglas, Webb , LANDER, Peter, Ambrose , LOHMAN, Mark, Christopher , PATEL, Vinod, Francis , VEPACHEDU, Sreenivasarao , XIE, Yongping
IPC: C07D498/04 , C07D471/04 , A61K31/4741 , A61K31/4745 , A61P35/00
CPC classification number: C07D471/04
Abstract: The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1296953A2
公开(公告)日：2003-04-02
申请号：EP01945932.0
申请日：2001-06-12
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , YORK, Jeremy Schulenburg
IPC: C07D215/22 , A61K31/47 , A61P35/00 , C07D401/12
CPC classification number: C07D215/22 , C07D401/12
Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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公开(公告)号：EP1250340A1
公开(公告)日：2002-10-23
申请号：EP00986242.6
申请日：2000-12-11
Applicant: ELI LILLY AND COMPANY , Wang, Qiuping
Inventor： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC: C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC classification number: C07D471/04
Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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Patent Agency Ranking
公开(公告)号：EP1713805B1
公开(公告)日：2009-06-10
申请号：EP05704878.7
申请日：2005-01-25
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , HAMDOUCHI, Chafiq, Hamdouchi , SHIH, Chuan , DE DIOS, Alfonso , DEL PRADO, Miriam, Filadelfa , JARAMILLO AGUADO, Carlos , KOTIYAN, Pramila , MADER, Mary, Margaret , SELGAS, Sheila, Pleite , SANCHEZ-MARTINEZ, Concepcion
IPC: C07D471/04 , A61K31/4188 , A61P29/00
CPC classification number: C07D471/04
Abstract: The present invention provides kinase inhibitors of Formula I.
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公开(公告)号：EP1720862A1
公开(公告)日：2006-11-15
申请号：EP05711246.8
申请日：2005-01-21
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , DALLY, Robert Dean , DE DIOS, Alfonso, Lilly S.A. , DEL PRADO CATALINA, Miriam Filadelfa, Lilly S.A. , DOMINGUEZ-FERNANDEZ, Carmen, Lilly S.A. , JARAMILLO AGUADO, Carlos, Lilly S.A. , LOPEZ DE URALDE-GARMENDIA, Beatriz, Lilly S.A. , MONTERO SALGADO, Carlos, Lilly S.A. , SHEPHERD, Timothy, Alan
IPC: C07D403/04 , C07D409/04 , A61K31/4184 , A61P35/00
CPC classification number: C07D471/04 , C07D403/04 , C07D413/04
Abstract: ABSTRACT The present invention provides kinase inhibitors of Formula I: .
Abstract translation: 摘要本发明提供了式I的激酶抑制剂：
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公开(公告)号：EP1543001A1
公开(公告)日：2005-06-22
申请号：EP03749105.7
申请日：2003-09-16
Applicant: ELI LILLY AND COMPANY
Inventor： BEIGHT, Douglas, Wade , BONJOUKLIAN, Rosanne , LIAO, Junkai , MCMILLEN, William, Thomas , PARKHURST, Brandon, Lee , SAWYER, Jason, Scott , YINGLING, Jonathan, Michael , YORK, Jeremy, Schulenburg
IPC: C07D471/04 , A61K31/41 , A61P35/00 , A61P17/00
CPC classification number: C07D471/04
Abstract: Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
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公开(公告)号：EP1392702A1
公开(公告)日：2004-03-03
申请号：EP02728409.0
申请日：2002-03-28
Applicant: ELI LILLY AND COMPANY
IPC: C07D498/14 , A61K31/435 , A61P35/00
CPC classification number: C07D498/14
Abstract: The present invention relates to a compound of Formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1713805A1
公开(公告)日：2006-10-25
申请号：EP05704878.7
申请日：2005-01-25
Applicant: ELI LILLY AND COMPANY
Inventor： BONJOUKLIAN, Rosanne , HAMDOUCHI, Chafiq, Hamdouchi , SHIH, Chuan , DE DIOS, Alfonso , DEL PRADO, Miriam, Filadelfa , JARAMILLO AGUADO, Carlos , KOTIYAN, Pramila , MADER, Mary, Margaret , SELGAS, Sheila, Pleite , SANCHEZ-MARTINEZ, Concepcion
IPC: C07D471/04 , A61K31/4188 , A61P29/00
CPC classification number: C07D471/04
Abstract: The present invention provides kinase inhibitors of Formula I.
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