公开(公告)号：EP1206457A1

公开(公告)日：2002-05-22

申请号：EP00959401.1

申请日：2000-08-23

申请人： ELI LILLY AND COMPANY ,  LIGAND PHARMACEUTICALS INCORPORATED

发明人： BROOKS, Dawn A. ,  RITO, Christopher, J. ,  SHUKER, Anthony, J. ,  DOMINIANNI, Samuel, J. ,  WARSHAWSKY, Alan, M. ,  GOSSETT, Lynn, S. ,  MATTHEWS, Donald, P. ,  HAY, David, A. ,  ARDECKY, Robert, J. ,  MICHELLYS, Pierre-Yves ,  TYHONAS, John. S.

IPC分类号： C07D263/32 ,  C07D277/24 ,  C07D413/10 ,  A61K31/421 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/506 ,  A61P3/10 ,  A61P9/00

CPC分类号： C07D413/10 ,  C07D263/32 ,  C07D277/24

摘要： Compounds represented by Formula (I) wherein n is 2, 3, or 4; V is O or S; W is O, S, or SO2 and at least one R5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; are modulators of peroxisome proliferator activated receptors and are useful in the treatment of type II diabetes and of cardiovascular diseases.

公开(公告)号：EP1206457B1

公开(公告)日：2003-10-15

申请号：EP00959401.1

申请日：2000-08-23

申请人： ELI LILLY AND COMPANY ,  LIGAND PHARMACEUTICALS INCORPORATED

发明人： BROOKS, Dawn A. ,  RITO, Christopher, J. ,  SHUKER, Anthony, J. ,  DOMINIANNI, Samuel, J. ,  WARSHAWSKY, Alan, M. ,  GOSSETT, Lynn, S. ,  MATTHEWS, Donald, P. ,  HAY, David, A. ,  ARDECKY, Robert, J. ,  MICHELLYS, Pierre-Yves ,  TYHONAS, John. S.

IPC分类号： C07D263/32 ,  C07D277/24 ,  C07D413/10 ,  A61K31/421 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/506 ,  A61P3/10 ,  A61P9/00

CPC分类号： C07D413/10 ,  C07D263/32 ,  C07D277/24

摘要： Compounds represented by Formula (I) wherein n is 2, 3, or 4; V is O or S; W is O, S, or SO2 and at least one R5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; are modulators of peroxisome proliferator activated receptors and are useful in the treatment of type II diabetes and of cardiovascular diseases.

公开(公告)号：EP0925063A1

公开(公告)日：1999-06-30

申请号：EP97934043.0

申请日：1997-06-30

申请人： ELI LILLY AND COMPANY

发明人： DOMINIANNI, Samuel, J. ,  FAUL, Margaret, M. ,  STUCKY, Russell, D. ,  WINNEROSKI, Leonard, L., Jr.

IPC分类号： C07C271 ,  C07C279 ,  C07D263

CPC分类号： C07D263/32 ,  C07C279/22

摘要： This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.

公开(公告)号：EP1019378B1

公开(公告)日：2004-09-29

申请号：EP97931523.1

申请日：1997-06-30

申请人： ELI LILLY AND COMPANY

发明人： DOMINIANNI, Samuel, J. ,  GRITTON, William, H.

IPC分类号： C07D217/12 ,  C07D217/22 ,  C07D401/00 ,  C07D401/14 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  C07D413/12 ,  C07D417/12 ,  C07D401/12

CPC分类号： C07D413/12

摘要： This invention provides 1,2,3,4-tetrahydroisoquinoline compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.

公开(公告)号：EP1019378A1

公开(公告)日：2000-07-19

申请号：EP97931523.1

申请日：1997-06-30

申请人： ELI LILLY AND COMPANY

发明人： DOMINIANNI, Samuel, J. ,  GRITTON, William, H.

IPC分类号： C07D217/12 ,  C07D217/22 ,  C07D401/00 ,  C07D401/14 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47

CPC分类号： C07D413/12

摘要： This invention provides 1,2,3,4-tetrahydroisoquinoline compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.

摘要翻译： 本发明提供了1,2,3,4-四氢异喹啉化合物及其药学上可接受的盐，所述化合物的药物制剂，以及治疗与非胰岛素依赖性糖尿病有关的高血糖和治疗高脂血症的方法。