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公开(公告)号:EP2014776A2
公开(公告)日:2009-01-14
申请号:EP08012765
申请日:2001-04-06
申请人: EPIGENOMICS AG
IPC分类号: C12Q1/68 , G01N27/62 , A61K31/711 , A61K48/00 , A61P7/04 , A61P9/10 , A61P11/06 , A61P13/12 , A61P29/00 , A61P35/00 , B01J19/00 , C07K14/46 , C07K14/47 , C07K14/82 , C12M1/00 , C12N15/09 , C12Q1/48 , G01N33/483 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号: C12Q1/6883 , C07K14/4703 , C07K14/82 , C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要: The present invention relates to the chemically modified genomic sequences of genes associated with DNA transcription, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with DNA transcription which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with DNA transcription.
摘要翻译: 本发明涉及与DNA转录相关的基因的化学修饰的基因组序列,涉及用于检测针对该序列的与DNA转录相关的基因的胞嘧啶甲基化状态的寡核苷酸和/或PNA-寡聚体,以及一种方法 用于确定与DNA转录相关的基因的遗传和/或表观遗传参数。