公开(公告)号：EP3390388A1

公开(公告)日：2018-10-24

申请号：EP16831494.6

申请日：2016-12-16

申请人： Ecole Normale Supérieure de Lyon ,  Centre National de la Recherche Scientifique ,  Université Claude Bernard Lyon I ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： MAURY, Olivier ,  GIRARD, Eric ,  ENGILBERG, Sylvain ,  RIOBE, François

IPC分类号： C07D401/14 ,  C07F5/00 ,  G01N23/223 ,  G01N33/58 ,  C07D413/14 ,  B01D9/00

CPC分类号： C07F5/003 ,  B01D9/005 ,  C07D401/14 ,  C07D413/14 ,  C30B7/14 ,  C30B29/58 ,  G01N23/223

摘要： The invention relates to cationic complexes made up of a lanthanide ion Ln3+ and a ligand of formula (I) with X, Y and R1 as defined in claim 1, and to the salts thereof with an anion, the solvates and hydrates thereof; with the exception of cationic complexes made up of a lanthanide ion Ln3+ and a ligand of one of formulae (1.1) or (1.4) as defined in claim 1, and the salts, solvates and hydrates thereof. The invention also relates to the use of such a complex or of a cationic complex made up of a lanthanide ion Ln3+ and a ligand of formula (1.1) or (1.4) as defined in claim 1, or of one of the salts thereof with an anion, the solvates or hydrates thereof, as an aid to the crystallisation of a biological macromolecule, as well as to crystallisation methods and methods for analysing or determining the structure of a biological macromolecule.