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    KIT AND METHOD FOR CHEMICAL FIXATION OF STENTLESS CARDIAC VALVULAR BIOPROSTHESES
    1.
    发明授权
    KIT AND METHOD FOR CHEMICAL FIXATION OF STENTLESS CARDIAC VALVULAR BIOPROSTHESES 有权
    FOR化学固氮菌生物人工心脏SET和方法阀，而不支撑环

    公开(公告)号：EP1041943B1

    公开(公告)日：2004-03-31

    申请号：EP98963192.4

    申请日：1998-12-15

    申请人： Edwards Lifesciences Corporation

    发明人： QUINTERO, Lillian ,  NGUYEN-THIEN-NHON, Diana

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2415 ,  Y10S623/901

    摘要： A system, apparatus and method for tanning of a stentless aortic bioprosthesis, and articles manufactured by such method. The system generally comprises a circulating bath which contains a tanning solution, and a support insert apparatus upon which the bioprosthesis is mounted during the tanning prosthesis. The support insert has i) two (2) coronary Sinus of Valsalva support projections for maintaining the coronary Sinuses of Valsalva in their substantially open, non-collapsed configurations, and ii) one (1) non-coronary Sinus of Valsalva support projection for maintaining the non-coronary Sinus of Valsalva in its substantially open, non-collapsed configuration, during tanning. Additionally, the system may include internal or external support members for maintaining the patency of right and left coronary artery segments, such coronary artery segments being permitted to remain attached to the Aortic bioprosthesis during tanning.

    FLEXIBLE HEART VALVE
    7.
    发明公开
    FLEXIBLE HEART VALVE 有权
    灵活的心脏瓣膜

    公开(公告)号：EP1143882A2

    公开(公告)日：2001-10-17

    申请号：EP00905730.8

    申请日：2000-01-26

    申请人： Edwards Lifesciences Corporation

    发明人： CARPENTIER, Alain, F. ,  SCHRECK, Stefan, G. ,  RHEE, Richard, S. ,  NGUYEN-THIEN-NHON, Diana ,  LAM, Hung, LY ,  RECKTENWALD, William

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2230/0013 ,  A61F2230/0023 ,  Y10S623/904

    摘要： A highly flexible tissue-type heart valve is disclosed having a structural stent in a generally cylindrical configuration with cusps and commissures that are permitted to move radially. The stent commissures are constructed so that the cusps are pivotably or flexibly coupled together at the commissures to permit relative movement therebetween. The stent may be cloth-covered and may be a single element or may be made in three separate elements for a three cusp valve, each element having a cusp portion and two commissure portions; adjacent commissure portions for each pair of adjacent stent element combining to form the stent commissures. If the stent has separate elements their commissure portions may be pivotably or flexibly coupled, or may be designed to completely separate into independent leaflets at bioresorbable couples. The cloth covering may have an outwardly projecting flap that mates with valve leaflets (e.g., pericardial leaflets) along the cusps and commissures. A connecting band may be provided that follows the cusps and commissures and extends outwardly. The valve is connected to the natural tissue along the undulating connecting band using conventional techniques, such as sutures. The connecting band may be a cloth-covered silicon member and attaches to the underside of the valve at the cusps to provide support to the stent and to the outer side of the valve at the commissures. A multi-legged holder is used to implant the valve, with the legs serving to maintain an implant shape to the valve. The holder may have six legs with one releasably connected to each cusp and one releasably connected to each commissure. A method of implantation of the flexible valve using the holder is also disclosed.

    PROSTHETIC HEART VALVE
    8.
    发明公开
    PROSTHETIC HEART VALVE 审中-公开

    公开(公告)号：EP4215161A1

    公开(公告)日：2023-07-26

    申请号：EP22215814.9

    申请日：2016-07-14

    申请人： Edwards Lifesciences Corporation

    发明人： NGUYEN-THIEN-NHON, Diana ,  GEISER, Timothy A. ,  WOOD, Larry ,  SIRIMANNE, Dinesh L. ,  NGUYEN, Son V. ,  LEVI, Tamir S. ,  GUROVICH, Nikolay ,  BUKIN, Michael

    IPC分类号： A61F2/24

    摘要： An implantable prosthetic valve can comprise an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration, the frame defining an axial direction extending from the inflow end to the outflow end, a leaflet structure positioned within the frame and secured thereto, and an annular outer skirt positioned around an outer surface of the frame, wherein the outer skirt comprises an inflow edge secured to the frame at a first location, an outflow edge comprising a plurality of alternating projections and notches, wherein the projections are secured to the frame at a second location, and the notches are not directly secured to the frame, an intermediate portion between the inflow edge and the outflow edge that comprises a plurality of openings.