公开(公告)号：EP0419905B1

公开(公告)日：1996-01-17

申请号：EP90117119.9

申请日：1990-09-05

申请人： Eisai Co., Ltd.

发明人： Abe, Shinya ,  Okamoto, Yasushi ,  Tagami, Katsuya ,  Hibi, Shigeki ,  Nagakawa, Junichi ,  Hirota, Kazuo ,  Hishinuma, Ieharu ,  Miyamoto, Kaname ,  Yamanaka, Takashi ,  Yokohama, Hiromitsu ,  Yoshimura, Tsutomu ,  Horie, Tohru ,  Akita, Yasunori ,  Katayama, Koichi ,  Yamatsu, Isao

IPC分类号： C07C66/00

CPC分类号： C07D295/185 ,  C07C45/00 ,  C07C47/575 ,  C07C50/38 ,  C07C59/54 ,  C07C59/68 ,  C07C59/90 ,  C07C65/21 ,  C07C66/00 ,  C07C69/734 ,  C07C69/738 ,  C07C255/31 ,  C07C255/41 ,  C07C255/57 ,  C07C317/46 ,  C07C323/55 ,  C07C323/56 ,  C07C323/62 ,  C07C2601/14 ,  C07C2601/16 ,  C07D211/46 ,  C07D213/55 ,  C07D277/30 ,  C07D277/46 ,  C07D309/04 ,  C07D333/24

公开(公告)号：EP0419905A2

公开(公告)日：1991-04-03

申请号：EP90117119.9

申请日：1990-09-05

申请人： Eisai Co., Ltd.

发明人： Abe, Shinya ,  Okamoto, Yasushi ,  Tagami, Katsuya ,  Hibi, Shigeki ,  Nagakawa, Junichi ,  Hirota, Kazuo ,  Hishinuma, Ieharu ,  Miyamoto, Kaname ,  Yamanaka, Takashi ,  Yokohama, Hiromitsu ,  Yoshimura, Tsutomu ,  Horie, Tohru ,  Akita, Yasunori ,  Katayama, Koichi ,  Yamatsu, Isao

IPC分类号： C07C66/00 ,  A61K31/19 ,  C07C59/90 ,  C07C59/68 ,  C07C65/21 ,  C07C69/736 ,  C07C255/38 ,  C07D309/00

CPC分类号： C07D295/185 ,  C07C45/00 ,  C07C47/575 ,  C07C50/38 ,  C07C59/54 ,  C07C59/68 ,  C07C59/90 ,  C07C65/21 ,  C07C66/00 ,  C07C69/734 ,  C07C69/738 ,  C07C255/31 ,  C07C255/41 ,  C07C255/57 ,  C07C317/46 ,  C07C323/55 ,  C07C323/56 ,  C07C323/62 ,  C07C2601/14 ,  C07C2601/16 ,  C07D211/46 ,  C07D213/55 ,  C07D277/30 ,  C07D277/46 ,  C07D309/04 ,  C07D333/24

摘要： The quinone compound is useful to treat hepatic disease and defined by the formula:
wherein A is a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group) or a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group, X and Y which may be the same or different from each other are each a hydroxyl group, a group represented by the formula
(wherein n is 0 or 1 and R 6 is a lower alkyl group), or an acyl group),

R 1 is an alkyl group having 2 to 20 carbon atoms, a cycloalkyl group, a cycloalkylalkyl group, an alkenyl group, an alkynyl group, an arylalkyl group, a group represented by the formula
(wherein p is an integer of 1 to 10), a heteroarylalkyl group, a group represented by the formula
{wherein q is an integer of 1 to 6 and B is a group represented by the formula:
(wherein r is 0 or an integer of 1 to 2, R 7 is a lower alkyl group, a cycloalkyl group or an aryl group), or a group represented by the formula -O-R 8 (wherein R 8 is a lower alkyl group or an aryl group)}, or a group represented by the formula
(wherein s is an integer of 1 to 3),
R 2 is a group represented by the formula -OR 8 (wherein R 8 is a hydrogen atom or a lower alkyl group) or a group represented by the formula:
(wherein R 9 and R 10 which may be the same of different from each other are each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group or a heteroaryl group, provided that R 9 and R 10 may be combined with each other to form a ring together with a nitrogen atom bonded thereto, which may further contain a nitrogen atom and/or an oxygen atom and may be substituted).

摘要翻译： 醌化合物可用于治疗肝病并由下式定义：其中A是由下式表示的基团：其中R 3，R 4和R 5可以是 相同或不同的是氢原子，低级烷基或低级烷氧基）或由下式表示的基团：其中R 3，R 4和R 5如下： 可以相同或不同的是氢原子，低级烷基或低级烷氧基，可以相同或不同的X和Y各自为羟基，由 （其中n为0或1，R 6为低级烷基）或酰基），R 1为碳原子数2〜20的烷基，芳基 环烷基，环烷基烷基，烯基，炔基，芳基烷基，由式表示的基团，其中p为1〜10的整数，杂芳基烷基基团 p为由式＆lparstr＆CH 2＆rparstr＆B B表示的基团，其中q为1〜6的整数，B为下式所示的基团：其中r为0或1〜2的整数，R 或者由式-OR 8表示的基团（其中R 8为低级烷基或芳基）}，或者式 由式＆lparstr＆CH2-CH2-O）@ CH3表示的基团（其中s为1至3的整数），R 2为由式-OR 8表示的基团（其中R 8为 氢原子或低级烷基）或由下式表示的基团：其中可以彼此不同的（其中R 9和R 1 各自为氢原子， 低级烷基，羟基烷基或杂芳基，条件是R 9和R 1可以彼此结合形成与其键合的氮原子一起形成的环，其还可含有氮 原子和/或氧原子并且可以被取代）。

公开(公告)号：EP0419905A3

公开(公告)日：1992-06-24

申请号：EP90117119.9

申请日：1990-09-05

申请人： Eisai Co., Ltd.

发明人： Abe, Shinya ,  Okamoto, Yasushi ,  Tagami, Katsuya ,  Hibi, Shigeki ,  Nagakawa, Junichi ,  Hirota, Kazuo ,  Hishinuma, Ieharu ,  Miyamoto, Kaname ,  Yamanaka, Takashi ,  Yokohama, Hiromitsu ,  Yoshimura, Tsutomu ,  Horie, Tohru ,  Akita, Yasunori ,  Katayama, Koichi ,  Yamatsu, Isao

IPC分类号： C07C66/00 ,  A61K31/19 ,  C07C59/90 ,  C07C59/68 ,  C07C65/21 ,  C07C69/736 ,  C07C255/38 ,  C07D309/00

CPC分类号： C07D295/185 ,  C07C45/00 ,  C07C47/575 ,  C07C50/38 ,  C07C59/54 ,  C07C59/68 ,  C07C59/90 ,  C07C65/21 ,  C07C66/00 ,  C07C69/734 ,  C07C69/738 ,  C07C255/31 ,  C07C255/41 ,  C07C255/57 ,  C07C317/46 ,  C07C323/55 ,  C07C323/56 ,  C07C323/62 ,  C07C2601/14 ,  C07C2601/16 ,  C07D211/46 ,  C07D213/55 ,  C07D277/30 ,  C07D277/46 ,  C07D309/04 ,  C07D333/24

摘要： The quinone compound is useful to treat hepatic disease and defined by the formula: wherein A is a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group) or a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group, X and Y which may be the same or different from each other are each a hydroxyl group, a group represented by the formula
(wherein n is 0 or 1 and R 6 is a lower alkyl group), or an acyl group),
R 1 is an alkyl group having 2 to 20 carbon atoms, a cycloalkyl group, a cycloalkylalkyl group, an alkenyl group, an alkynyl group, an arylalkyl group, a group represented by the formula
(wherein p is an integer of 1 to 10), a heteroarylalkyl group, a group represented by the formula
{wherein q is an integer of 1 to 6 and B is a group represented by the formula:
(wherein r is 0 or an integer of 1 to 2, R 7 is a lower alkyl group, a cycloalkyl group or an aryl group), or a group represented by the formula -O-R 8 (wherein R 8 is a lower alkyl group or an aryl group)}, or a group represented by the formula (wherein s is an integer of 1 to 3), R 2 is a group represented by the formula -OR 8 (wherein R 8 is a hydrogen atom or a lower alkyl group) or a group represented by the formula:
(wherein R 9 and R 10 which may be the same of different from each other are each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group or a heteroaryl group, provided that R 9 and R 10 may be combined with each other to form a ring together with a nitrogen atom bonded thereto, which may further contain a nitrogen atom and/or an oxygen atom and may be substituted).

摘要翻译： 醌化合物可用于治疗肝病并由下式定义：其中A是由下式表示的基团：其中R 3，R 4和R 5可以是 相同或不同的是氢原子，低级烷基或低级烷氧基）或由下式表示的基团：其中R 3，R 4和R 5如下： 可以相同或不同的是氢原子，低级烷基或低级烷氧基，可以相同或不同的X和Y各自为羟基，由 （其中n为0或1，R 6为低级烷基）或酰基），R 1为碳原子数2〜20的烷基，芳基 环烷基，环烷基烷基，烯基，炔基，芳基烷基，由式表示的基团，其中p为1〜10的整数，杂芳基烷基基团 p为由式＆lparstr＆CH 2＆rparstr＆B B表示的基团，其中q为1〜6的整数，B为下式所示的基团：其中r为0或1〜2的整数，R 或者由式-OR 8表示的基团（其中R 8为低级烷基或芳基）}，或者式 由式＆lparstr＆CH2-CH2-O）@ CH3表示的基团（其中s为1至3的整数），R 2为由式-OR 8表示的基团（其中R 8为 氢原子或低级烷基）或由下式表示的基团：其中可以彼此不同的（其中R 9和R 1 各自为氢原子， 低级烷基，羟基烷基或杂芳基，条件是R 9和R 1可以彼此结合形成与其键合的氮原子一起形成的环，其还可含有氮 原子和/或氧原子并且可以被取代）。