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公开(公告)号：EP0353474B1
公开(公告)日：1995-04-05
申请号：EP89112204.6
申请日：1989-07-04
申请人： Eisai Co., Ltd.
发明人： Okano, Kazuo , Asano, Osamu , Shimomura, Naoyuki , Kawahara, Tetsuya , Abe, Shinya , Miyazawa, Shuhei , Miyamoto, Mitsuaki , Yoshimura, Hiroyuki , Harada, Koukichi , Nagaoka, Junsaku , Kawata, Tsutomu , Yoshimura, Tsutomu , Suzuki, Hiromasa , Souda, Shigeru , Machida, Yoshimasa , Katayama, Kouichi , Yamatsu, Isao
IPC分类号： C07D213/40 , C07D405/12 , C07D401/12 , C07D401/06 , A61K31/44
CPC分类号： C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , Y10S514/921
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公开(公告)号：EP0149847A3
公开(公告)日：1989-11-08
申请号：EP84116353.8
申请日：1984-12-27
申请人： Eisai Co., Ltd.
发明人： Yamatsu, Isao , Suzuki, Takeshi , Abe, Shinya , Nakamoto, Kouji , Kajiwara, Akiharu , Katayama, Kouichi , Tsunoda, Hajime , Murakami, Manabu , Ono, Hideki , Yamada, Kouji
IPC分类号： A61K31/045 , A61K31/66
CPC分类号： A61K31/045 , A61K31/66
摘要： Dolichol or phosphate thereof is useful as a therapeutically treating and preventive agent, in particular, for hyperuricuria, hyperlipemia, diabetes and hepatic diseases.
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3.发明授权
公开(公告)号：EP0107188B1
公开(公告)日：1986-02-26
申请号：EP83110533.3
申请日：1983-10-21
申请人： Eisai Co., Ltd.
发明人： Katoh, Yoshinori , Tajima, Tetsuya , Yamatsu, Isao , Suzuki, Takeshi , Abe, Shinya , Kajihara, Akiharu , Sugitani, Tohru
CPC分类号： A61K31/20 , C07C57/03 , Y10S514/825
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公开(公告)号：EP0149847A2
公开(公告)日：1985-07-31
申请号：EP84116353.8
申请日：1984-12-27
申请人： Eisai Co., Ltd.
发明人： Yamatsu, Isao , Suzuki, Takeshi , Abe, Shinya , Nakamoto, Kouji , Kajiwara, Akiharu , Katayama, Kouichi , Tsunoda, Hajime , Murakami, Manabu , Ono, Hideki , Yamada, Kouji
IPC分类号： A61K31/045 , A61K31/66
CPC分类号： A61K31/045 , A61K31/66
摘要： Dolichol or phosphate thereof is useful as a therapeutically treating and preventive agent, in particular, for hyperuricuria, hyperlipemia, diabetes and hepatic diseases.
摘要翻译： 多立方醇或其磷酸盐可用作治疗和预防剂，特别是用于尿尿尿，高脂血症，糖尿病和肝脏疾病。
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5.发明授权6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraene-2-ol, a process for producing same and a pharmaceutical composition 失效6,10,14,18-四甲基-5,9,13,17-壬二烯-2-醇，其制备方法和药物组合物
公开(公告)号：EP0046995B1
公开(公告)日：1983-05-25
申请号：EP81106734.7
申请日：1981-08-28
申请人： Eisai Co., Ltd.
发明人： Yamatsu, Isao , Inai, Yuichi , Abe, Shinya , Suzuki, Takeshi , Ohgou, Toshiharu , Murakami, Manabu , Oketani, Kiyoshi , Fujisaki, Hideaki
IPC分类号： C07C33/02 , C07C29/136 , A61K31/045
CPC分类号： C07C33/02
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6.发明公开Pharmaceutical preparations comprising polyprenyl compounds, especially as anti-cancer agents, and pharmaceutical compositions for the prevention and treatment of cancer and skin diseases 失效含有特别是医疗制剂Polyprenylderivate具有抗癌活性，癌症和皮肤病的预防和治疗的治疗组合物。
公开(公告)号：EP0059258A1
公开(公告)日：1982-09-08
申请号：EP81109393.9
申请日：1981-10-30
申请人： Eisai Co., Ltd.
发明人： Yamatsu, Isao , Inai, Yuichi , Abe, Shinya , Suzuki, Takeshi , Suzuki, Yoshikazu , Tagaya, Osamu , Suzuki, Kouichi , Abe, Kouichi , Yamada, Kouji
IPC分类号： C07C57/03 , C07C69/533 , C07C69/587 , C07C103/133 , C07C49/203 , A61K31/12 , A61K31/23 , A61K31/16
CPC分类号： A61K31/23 , A61K31/12 , A61K31/16 , C07C49/203 , C07C57/03
摘要： group, or
in which each of n and m is 0, 1 or 2, n + m is 0, 1 or 2,
and B is
or
[in which R represents a hydroxyl group, a lower alkoxy (wherein each of R, and R 2 is a hydrogen atom, a lower alkyl group or an aryl group)]; provided that R is a lower alkoxy or
especially as anti-cancer agent.摘要翻译： 药物组合物，其包含具有下式的聚异戊二烯类化合物：
Ñ -
7.发明公开Conjugated polyprenylcarboxylic acids and their derivatives as well as pharmaceutical preparations containing these compounds 失效共轭Polyprenylcarbonsäuren和它们的衍生物和含有它们的药物组合物。
公开(公告)号：EP0054732A1
公开(公告)日：1982-06-30
申请号：EP81109391.3
申请日：1981-10-30
申请人： Eisai Co., Ltd.
发明人： Yamatsu, Isao , Inai, Yuichi , Abe, Shinya , Suzuki, Takeshi , Suzuki, Yoshikazu , Tagaya, Osamu , Suzuki, Kouichi , Abe, Kouichi , Yamada, Kouji
IPC分类号： C07C57/03 , C07C69/587 , C07C103/133 , A61K31/19 , A61K31/23 , A61K31/16
摘要： A conjugated polyprenylcarboxylic acid and its derivative having the formula:
in which each of n and m is 0, 1 or 2, n+m is 1 or 2, A is
and R is a hydroxyl group, a lower alkoxy group or
wherein each of R, and R 2 represents a hydrogen atom, a lower alkyl group, or an aryl group; provided that R is
n is 1 and m is 0.
There are also descrived pharmaceutical preparations containing above compounds.-
8.发明公开Alpha,beta-dihydropolyprenyl derivatives, process for preparing these derivatives, pharmacological preparations containing them and method for treating liver diseases 失效ALPHA，β-二羟基丙基衍生物，制备这些衍生物的方法，含有它们的药理学制剂及其治疗肝病的方法
公开(公告)号：EP0041235A3
公开(公告)日：1982-02-24
申请号：EP81104084
申请日：1981-05-27
申请人： Eisai Co., Ltd.
发明人： Yamatsu, Isao , Inai, Yuichi , Abe, Shinya , Watanabe, Hideaki , Igarashi, Toshiji , Shiojiri, Hiroyuki , Tanabe, Yoshio , Hara, Kuniko
IPC分类号： C07C69/52 , C07C69/007 , C07C57/03 , C07C33/02 , C07C67/22 , C07C51/08 , C07C29/136 , A61K31/22 , A61K31/20 , A61K31/045
CPC分类号： C07C255/00 , C07C29/147 , C07C33/02 , C07C33/025 , C07C57/03 , C07C67/08 , C07C69/145 , C07C69/587 , Y10S514/894
摘要： An α,β-dihydropolyprenyl derivative having the formula (I):
wherein X represents a group of-COOR 1 or-CH 2 OR 2 in which R, is the hydrogen atom or a lower alkyl group and R 2 is the hydrogen atom or an aliphatic acyl group having one to four carbon atoms; and n is an integer of one to four. A process for the preparation of the α,β-dihydropolyprenyl derivative and a therapeutic agent for treatment of liver diseases comprising the same are also disclosed.-
9.发明授权Thieno 3.2-f 1,2,4 triazolo 4,3-a 1,4 -diazepine derivatives as PAF antagonists 失效噻吩3,2-f 1,2,4-三唑并[4,3-a 1,4二氮杂苯并呋喃酮] PAF拮抗剂
公开(公告)号：EP0606103B1
公开(公告)日：2003-03-12
申请号：EP94101416.9
申请日：1989-10-26
申请人： Eisai Co., Ltd.
发明人： Okano, Kazuo , Miyazawa, Shuhei , Clark, Richard Stephen John , Abe, Shinya , Kawahara, Tetsuya , Shimomura, Naoyuki 302, Matsushiro Parkside height , Asano, Osamu , Yoshimura, Hiroyuki , Miyamoto, Mitsuaki , Sakuma, Yoshinori , Muramoto, Kenzo , Obaishi, Hiroshi , Harada, Koukichi , Tsunoda, Hajime , Katayama, Satoshi , Yamada, Kouji , Souda, Shigeru , Machida, Yoshimasa , Katayama, Kouichi , Yamatsu, Isao
IPC分类号： C07D495/22 , C07D495/14 , A61K31/55
CPC分类号： C07D495/14 , C07F9/6561
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10.发明授权Thieno[3,2-f](1,2,4-triazolo)[4,3-a]1,4-diazepine derivatives as PAF antagonists 失效噻吩并[3,2-f]（1,2,4-三唑并）[4,3-a] 1,4-二氮杂苯并呋喃PAF拮抗剂
公开(公告)号：EP0677524B1
公开(公告)日：2002-02-13
申请号：EP95111206.9
申请日：1989-10-26
申请人： Eisai Co., Ltd.
发明人： Okano, Kazuo , Miyazawa, Shuhei , Clark, Richard Stephen J. , Abe, Shinya , Kawahara, Tetsuya , Shimomura, Naoyuki , Asano, Osamu , Yoshimura, Hiroyuki , Miyamoto, Mitsuaki , Sakuma, Yoshinori , Muramoto, Kenzo , Obaishi, Hiroshi , Harada, Koukichi , Tsunoda, Hajime , Katayama, Satoshi , Yamada, Kouji , Souda, Shigeru , Machida, Yoshimasa , Katayama, Kouichi , Yamatsu, Isao
IPC分类号： C07D495/22 , C07D495/14 , A61K31/55
CPC分类号： C07D495/14 , C07F9/6561
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