公开(公告)号：EP1216980A1

公开(公告)日：2002-06-26

申请号：EP00962993.2

申请日：2000-09-29

申请人： Eisai Co., Ltd.

发明人： SHINODA, Masanobu ,  EMORI, Eita ,  MATSUURA, Fumiyoshi ,  KANEKO, Toshihiko ,  OHI, Norihito ,  KASAI, Shunji ,  YOSHITOMI, Hideki ,  YAMAZAKI, Kazuto ,  MIYASHITA, Sadakazu ,  HIBARA, Taro ,  SEIKI, Takashi ,  CLARK, Richard ,  HARADA, Hitoshi

IPC分类号： C07C59/66

CPC分类号： C07D213/30 ,  C07C59/66 ,  C07C59/68 ,  C07C233/51 ,  C07C233/55 ,  C07C233/87 ,  C07C235/34 ,  C07C235/38 ,  C07C235/52 ,  C07C235/60 ,  C07C235/78 ,  C07C235/84 ,  C07C255/57 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/14 ,  C07D209/42 ,  C07D213/55 ,  C07D213/56 ,  C07D213/81 ,  C07D213/82 ,  C07D215/04 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/52 ,  C07D241/24 ,  C07D261/18 ,  C07D263/26 ,  C07D263/32 ,  C07D277/20 ,  C07D277/30 ,  C07D277/34 ,  C07D277/56 ,  C07D307/54 ,  C07D307/79 ,  C07D333/24 ,  C07D401/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin-resistant improver, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula (I), a salt thereof, an ester thereof or a hydrate of them.
In the formula, R 1 represents hydrogen atom, hydroxyl group or a C 1-6 alkyl group etc. which may have one or more substituents; L represents a single or double bond or a C 1-6 alkylene group etc. which may have one or more substituents; M represents a single bond or a C 1-6 alkylene group etc. which may have one or more substituents; T represents a single bond or a C 1-3 alkylene group which may have one or more substituents; W represents carboxyl group or a group represented by the formula -CON(R w1 )R w2 (wherein R w1 and R w2 are the same as or different from each other and each represents hydrogen atom, formyl group etc.) etc.; represents a single or double bond; X represents oxygen atom or a C 2-6 alkenylene group etc. which may have one or more substituents; Y represents a C 5-12 aromatic hydrocarbon group etc. which may have one or more substituents and which may have one or more heteroatoms; and ring Z represents a C 5-6 aromatic hydrocarbon group which may have 0 to 4 substituents and which may have one or more heteroatoms.

摘要翻译： 本发明提供了可用作胰岛素抗性改良剂的新型羧酸化合物，其盐或其水合物，以及包含该化合物作为活性成分的药物。 也就是说，本发明提供由下式（I）表示的羧酸化合物，其盐，酯或它们的水合物。 在该式中，R 1表示氢原子，羟基或可具有一个或多个取代基的C 1-6烷基等; L表示可具有一个或多个取代基的单键或双键或C 1-6亚烷基等; M表示可具有一个或多个取代基的单键或C 1-6亚烷基等; T表示单键或可具有一个或多个取代基的C 1-3亚烷基; W表示羧基或由式-CON（R 1）R w表示的基团（其中R 1和R 2彼此相同或不同，各自表示氢原子，甲酰基 组等）等 代表单键或双键; X表示氧原子或可具有一个或多个取代基的C 2-6亚烯基等; Y表示可具有一个或多个取代基且可具有一个或多个杂原子的C 5-12芳族烃基等。 并且环Z表示可具有0至4个取代基且可具有一个或多个杂原子的C 5-6芳族烃基。