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1.发明授权Carboximide derivatives, process for their production and medicines containing same 失效碳酰亚胺衍生物，其生产方法及含有其的药物
公开(公告)号：EP0111226B1
公开(公告)日：1987-09-16
申请号：EP83111830.2
申请日：1983-11-25
申请人： Eisai Co., Ltd.
发明人： Hirose, Noriyasu , Souda, Shigeru , Miyake, Kazutoshi , Kuriyama, Shizuo , Usuki, Kazuyasu , Akiyama, Yasuhiro , Nagaoka, Naoko , Kawashima, Hidetoshi
IPC分类号： C07D209/48 , C07D209/76 , C07D401/12 , C07D403/12 , A61K31/40
CPC分类号： C07D209/48 , C07D209/76 , C07D401/12 , C07D403/12
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2.发明公开Carboximide derivatives, process for their production and medicines containing same 失效甲酰亚胺衍生物，含有它们的制备方法和药物。
公开(公告)号：EP0111226A1
公开(公告)日：1984-06-20
申请号：EP83111830.2
申请日：1983-11-25
申请人： Eisai Co., Ltd.
发明人： Hirose, Noriyasu , Souda, Shigeru , Miyake, Kazutoshi , Kuriyama, Shizuo , Usuki, Kazuyasu , Akiyama, Yasuhiro , Nagaoka, Naoko , Kawashima, Hidetoshi
IPC分类号： C07D209/48 , C07D209/76 , C07D401/12 , C07D403/12 , A61K31/40
CPC分类号： C07D209/48 , C07D209/76 , C07D401/12 , C07D403/12
摘要： A carboximide derivative represented by the general formula:
wherein X is
Z is alkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkenyl or arylalkenyl, and Y is a substituted or unsubstituted pyridyl, pyrimidyl or phenyl group, and a pharmaceutically acceptable acid addition salt thereof. The carboximide derivative and acid addition salt are useful for treating diabetes and also for depressing the central nervous system. The carboximide derivative may be produced by reacting a sodium alkoxide represented by the general formula:
wherein X and Y have the same meanings as defined above, with Z·Hal wherein Hal is a halogen and Z has the same meaning as defined above.
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