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1.发明授权1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease 失效1,4-取代哌啶乙酰胆碱酯酶抑制剂及其对阿尔茨海默氏病的治疗
公开(公告)号：EP0296560B1
公开(公告)日：1996-02-28
申请号：EP88109924.6
申请日：1988-06-22
申请人： Eisai Co., Ltd.
发明人： Sugimoto, Hachiro , Tsuchiya, Yutaka , Higurashi, Kunizou , Karibe, Norio , Iimura, Yuoichi , Sasaki, Atsushi , Yamanashi, Yoshiharu , Ogura, Hiroo , Araki, ShinKashiwa Mansion 401, 11-6 , Kosasa, Takashi , Kusota, Atsuhiko , Kozasa, Michiko , Yamatsu, Kiyomi
IPC分类号： C07D211/26 , C07D211/28 , C07D211/32 , C07D211/34 , C07D471/04 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , A61K31/445
CPC分类号： C07D401/06 , C07D207/09 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/34 , C07D211/44 , C07D211/70 , C07D211/76 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D471/04 , Y10S152/90
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2.发明公开1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease 失效环状氨基的化合物，它们的用途和含有它们的药物组合物。
公开(公告)号：EP0296560A2
公开(公告)日：1988-12-28
申请号：EP88109924.6
申请日：1988-06-22
申请人： Eisai Co., Ltd.
发明人： Sugimoto, Hachiro , Tsuchiya, Yutaka , Higurashi, Kunizou , Karibe, Norio , Iimura, Yuoichi , Sasaki, Atsushi , Yamanashi, Yoshiharu , Ogura, Hiroo , Araki, Shin Kashiwa Mansion 401, 11-6 , Kosasa, Takashi , Kusota, Atsuhiko , Kozasa, Michiko , Yamatsu, Kiyomi
IPC分类号： C07D211/26 , C07D211/28 , C07D211/32 , C07D211/34 , C07D471/04 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , A61K31/445
CPC分类号： C07D401/06 , C07D207/09 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/34 , C07D211/44 , C07D211/70 , C07D211/76 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D471/04 , Y10S152/90
摘要： A cyclic amine compound is defined by the formula:
in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, = (CH-CH = CH)b-, = CH-(CH2)c- or = (CH-CH)d = and the ring including T and Q is piperidine. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.摘要翻译： 环状胺化合物由下式定义：
其中J是茚满基，茚满酮基，茚基，indenonyl，indanedionyl，tetralonyl，benzosuberonyl，indanolyl或其二价基团，K为苯基，在芳基烷基或cynnamyl，B是 - （CHR 22）R，R22为H或甲基，-CO - （CHR 22）R，b =（CH-CH = CH）= CH-（CH 2）c-或=（CH-CH）D =和 包括环T和Q是哌啶。 该化合物可用于药物组合物的制备和针对老年性痴呆有效的药物是有用的。 -
3.发明公开
公开(公告)号：EP0296560A3
公开(公告)日：1990-05-02
申请号：EP88109924.6
申请日：1988-06-22
申请人： Eisai Co., Ltd.
发明人： Sugimoto, Hachiro , Tsuchiya, Yutaka , Higurashi, Kunizou , Karibe, Norio , Iimura, Yuoichi , Sasaki, Atsushi , Yamanashi, Yoshiharu , Ogura, Hiroo , Araki, Shin Kashiwa Mansion 401, 11-6 , Kosasa, Takashi , Kusota, Atsuhiko , Kozasa, Michiko , Yamatsu, Kiyomi
IPC分类号： C07D211/26 , C07D211/28 , C07D211/32 , C07D211/34 , C07D471/04 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , A61K31/445
CPC分类号： C07D401/06 , C07D207/09 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/34 , C07D211/44 , C07D211/70 , C07D211/76 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D471/04 , Y10S152/90
摘要： A cyclic amine compound is defined by the formula:
in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, = (CH-CH = CH)b-, = CH-(CH2)c- or = (CH-CH)d = and the ring including T and Q is piperidine. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.
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